Zobrazeno 1 - 10
of 71
pro vyhledávání: '"P. Loguercio Polosa"'
Autor:
Morena Miciaccia, Francesca Rizzo, Antonella Centonze, Gianfranco Cavallaro, Marialessandra Contino, Domenico Armenise, Olga Maria Baldelli, Roberta Solidoro, Savina Ferorelli, Pasquale Scarcia, Gennaro Agrimi, Veronica Zingales, Elisa Cimetta, Simone Ronsisvalle, Federica Maria Sipala, Paola Loguercio Polosa, Cosimo Gianluca Fortuna, Maria Grazia Perrone, Antonio Scilimati
Publikováno v:
Pharmaceuticals, Vol 17, Iss 1, p 135 (2024)
Diffuse intrinsic pontine glioma (DIPG), affecting children aged 4–7 years, is a rare, aggressive tumor that originates in the pons and then spreads to nearby tissue. DIPG is the leading cause of death for pediatric brain tumors due to its infiltra
Externí odkaz:
https://doaj.org/article/8511af1c24944524bc20ff6f3007c237
Publikováno v:
Life, Vol 13, Iss 9, p 1863 (2023)
In mammalian mitochondria, the processing of primary RNA transcripts involves a coordinated series of cleavage and modification events, leading to the formation of processing intermediates and mature mt-RNAs. RNA19 is an unusually stable unprocessed
Externí odkaz:
https://doaj.org/article/c477075f692045198e39b5d490f0556c
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10420 (2023)
Mitochondria play a key role in cancer and their involvement is not limited to the production of ATP only. Mitochondria also produce reactive oxygen species and building blocks to sustain rapid cell proliferation; thus, the deregulation of mitochondr
Externí odkaz:
https://doaj.org/article/d155f8319aee4892a51dd74c82f46b70
Autor:
Morena Miciaccia, Benny Danilo Belviso, Mariaclara Iaselli, Gino Cingolani, Savina Ferorelli, Marianna Cappellari, Paola Loguercio Polosa, Maria Grazia Perrone, Rocco Caliandro, Antonio Scilimati
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract The beneficial effects of Cyclooxygenases (COX) inhibitors on human health have been known for thousands of years. Nevertheless, COXs, particularly COX-1, have been linked to a plethora of human diseases such as cancer, heart failure, neurol
Externí odkaz:
https://doaj.org/article/e348145f07bc4650920473b1d5b3a4fd
Akademický článek
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Autor:
Stanka Matic, Min Jiang, Thomas J. Nicholls, Jay P. Uhler, Caren Dirksen-Schwanenland, Paola Loguercio Polosa, Marie-Lune Simard, Xinping Li, Ilian Atanassov, Oliver Rackham, Aleksandra Filipovska, James B. Stewart, Maria Falkenberg, Nils-Göran Larsson, Dusanka Milenkovic
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
It has been debated whether premature ageing in mitochondrial DNA mutator mice is driven by point mutations or deletions of mtDNA. Matic et al generate Mgme1 knockout mice and show here that these mice have tissue-specific replication stalling and ac
Externí odkaz:
https://doaj.org/article/e4875b41d2804c3a99656ff7ae1c7aca
Akademický článek
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Autor:
Francesco Capriglia, Francesca Rizzo, Giuseppe Petrosillo, Veronica Morea, Giulia d’Amati, Palmiro Cantatore, Marina Roberti, Paola Loguercio Polosa, Francesco Bruni
Publikováno v:
Life, Vol 11, Iss 7, p 674 (2021)
The m.3243A>G mutation within the mitochondrial mt-tRNALeu(UUR) gene is the most prevalent variant linked to mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS) syndrome. This pathogenic mutation causes severe impairmen
Externí odkaz:
https://doaj.org/article/abe9ed0abae04b0196ecea47b2475768
Autor:
Metodi Dimitrov Metodiev, Henrik Spåhr, Paola Loguercio Polosa, Caroline Meharg, Christian Becker, Janine Altmueller, Bianca Habermann, Nils-Göran Larsson, Benedetta Ruzzenente
Publikováno v:
PLoS Genetics, Vol 10, Iss 2, p e1004110 (2014)
Biogenesis of mammalian mitochondrial ribosomes requires a concerted maturation of both the small (SSU) and large subunit (LSU). We demonstrate here that the m(5)C methyltransferase NSUN4, which forms a complex with MTERF4, is essential in mitochondr
Externí odkaz:
https://doaj.org/article/e4e96e7dd2814f93af1a61db16c09825
Akademický článek
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