Zobrazeno 1 - 10
of 34
pro vyhledávání: '"P. Leon Brown"'
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 17 (2023)
IntroductionClinically relevant sex differences have been noted in a number of affective, behavioral, cognitive, and neurological health disorders. Midbrain dopamine neurons are implicated in several of these same disorders and consequently are under
Externí odkaz:
https://doaj.org/article/ea7a07f4e0994ac8a4fb612df7830d3b
Autor:
Leiming Wang, Hanbing Lu, P Leon Brown, William Rea, Bruce Vaupel, Yihong Yang, Elliot Stein, Paul D Shepard
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127773 (2015)
Manganese-enhanced magnetic resonance imaging (MEMRI) is a powerful technique for assessing the functional connectivity of neurons within the central nervous system. Despite the widely held proposition that MEMRI signal is dependent on neuronal activ
Externí odkaz:
https://doaj.org/article/3c315989e36744d0b4f00eca879ff018
Autor:
Paul Leon Brown, Paul D Shepard
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60678 (2013)
Midbrain dopamine neurons are an essential part of the circuitry underlying motivation and reinforcement. They are activated by rewards or reward-predicting cues and inhibited by reward omission. The lateral habenula (lHb), an epithalamic structure t
Externí odkaz:
https://doaj.org/article/488915f43ab34e9d9fcdbec4d6e3cf25
Publikováno v:
International Journal of Neuropsychopharmacology
Background The volatile anesthetic isoflurane may exert a rapid and long-lasting antidepressant effect in patients with medication-resistant depression. The mechanism underlying the putative therapeutic actions of the anesthetic have been attributed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5842fb8f5d01df500c5d665428a5367c
https://doi.org/10.1093/ijnp/pyy029
https://doi.org/10.1093/ijnp/pyy029
The Research Domain Criteria (RDoC) initiative was implemented to reorient the approach to mental health research from one focused on Diagnostic and Statistical Manual of Mental Disorders (DSM) nosology to one oriented to psychological constructs con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75f55dab2eaaa6fe9995533da2092b6
https://europepmc.org/articles/PMC4988756/
https://europepmc.org/articles/PMC4988756/
Autor:
Paul D. Shepard, P. Leon Brown
Publikováno v:
Journal of neurophysiology. 116(3)
The lateral habenula, a phylogenetically conserved epithalamic structure, is activated by aversive stimuli and reward omission. Excitatory efferents from the lateral habenula predominately inhibit midbrain dopamine neuronal firing through a disynapti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da55650d734369ce5d1ebe646209a0e9
https://pubmed.ncbi.nlm.nih.gov/27358317
https://pubmed.ncbi.nlm.nih.gov/27358317
Autor:
Carrie Schoonover, P. Leon Brown, Paul D. Shepard, Martin Greenwald, Irina N. Krasnova, Cheryl L. Mayo, Rebecca McFarland, Greg I. Elmer, Michael W. Vogel, Sara L. Stockman, Jean Lud Cadet
Publikováno v:
European Journal of Neuroscience. 36:2773-2781
Adult rats exposed to the DNA-methylating agent methylazoxymethanol on embryonic day 17 show a pattern of neurobiological deficits that model some of the neuropathological and behavioral changes observed in schizophrenia. Although it is generally ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff524469b09cacf8c1da01d73d6305e9
https://doi.org/10.1111/j.1460-9568.2012.08204.x
https://doi.org/10.1111/j.1460-9568.2012.08204.x
Publikováno v:
European Journal of Neuroscience. 30:1941-1946
Orbitofrontal cortex (OFC) is critical for reversal learning. Reversal deficits are typically demonstrated in complex settings that combine Pavlovian and instrumental learning. Yet recent work has implicated the OFC specifically in behaviors guided b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d07968715490da1406a986c56aab6b6d
https://doi.org/10.1111/j.1460-9568.2009.06992.x
https://doi.org/10.1111/j.1460-9568.2009.06992.x
Publikováno v:
The Journal of Neuroscience. 29:13365-13376
The ventral striatum (VS) is thought to serve as a gateway whereby associative information from the amygdala and prefrontal regions can influence motor output to guide behavior. If VS mediates this “limbic–motor” interface, then one might expec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85cf00e23d0a62152edd7e8990594e7a
https://doi.org/10.1523/jneurosci.2572-09.2009
https://doi.org/10.1523/jneurosci.2572-09.2009
Publikováno v:
European Journal of Neuroscience. 26:1242-1253
To clarify the role of brain temperature in permeability of the blood–brain barrier (BBB), rats were injected with methamphetamine (METH 9 mg/kg) at normal (23 °C) and warm (29 °C) environmental conditions and internal temperatures were monitored
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ced663931d239c6fc2a86aed9b80fbf7
https://doi.org/10.1111/j.1460-9568.2007.05741.x
https://doi.org/10.1111/j.1460-9568.2007.05741.x