Zobrazeno 1 - 10
of 414
pro vyhledávání: '"P. Leif Bergsagel"'
Autor:
Francesco Maura, David G. Coffey, Caleb K. Stein, Esteban Braggio, Bachisio Ziccheddu, Meaghen E. Sharik, Megan T. Du, Yuliza Tafoya Alvarado, Chang-Xin Shi, Yuan Xiao Zhu, Erin W. Meermeier, Gareth J. Morgan, Ola Landgren, P. Leif Bergsagel, Marta Chesi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Multiple myeloma (MM) is a heterogeneous disease characterized by frequent MYC translocations. Sporadic MYC activation in the germinal center of genetically engineered Vk*MYC mice is sufficient to induce plasma cell tumors in which a variety
Externí odkaz:
https://doaj.org/article/0fb36d4f85d4436b947de3da11cd1f2d
Autor:
Linda B. Baughn, Erik Jessen, Neeraj Sharma, Hongwei Tang, James B. Smadbeck, Mark D. Long, Kathryn Pearce, Matthew Smith, Surendra Dasari, Zohar Sachs, Michael A. Linden, Joselle Cook, A. Keith Stewart, Marta Chesi, Amit Mitra, P. Leif Bergsagel, Brian Van Ness, Shaji K. Kumar
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Multiple myeloma (MM) remains an incurable plasma cell (PC) malignancy. Although it is known that MM tumor cells display extensive intratumoral genetic heterogeneity, an integrated map of the tumor proteomic landscape has not been comprehens
Externí odkaz:
https://doaj.org/article/5804789b64654223a5493d1fe1a65ff0
Autor:
Radhika Bansal, Mizba Baksh, Jeremy T. Larsen, Matthew A. Hathcock, David Dingli, A. Keith Stewart, Prashant Kapoor, Taxiarchis Kourelis, Suzanne R. Hayman, Rahma M. Warsame, Rafael Fonseca, P. Leif Bergsagel, Sikander Ailawadhi, Shaji K. Kumar, Yi Lin
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-5 (2023)
Abstract Bone marrow (BM) assessment of minimal residual disease (MRD) is prognostic for survival in multiple myeloma (MM). BM is still hypocellular at month 1 post CAR-T, thus the value of MRD negative (MRDneg) status at this timepoint is unclear. W
Externí odkaz:
https://doaj.org/article/fc98ec2442174aae8ca613b312533fc7
Autor:
Rodrigo Fonseca, Mariano Arribas, Julia E. Wiedmeier-Nutor, Yael N. Kusne, Miguel González Vélez, Heidi E. Kosiorek, Richard (Duke) J. Butterfield, Ilan R. Kirsch, Joseph R. Mikhael, A. Keith Stewart, Craig Reeder, Jeremy Larsen, P. Leif Bergsagel, Rafael Fonseca
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Minimal residual disease (MRD) assays allow response assessment in patients with multiple myeloma (MM), and negativity is associated with improved survival outcomes. The role of highly sensitive next generation sequencing (NGS) MRD in combin
Externí odkaz:
https://doaj.org/article/5c9ef42c664f419abb790369e9116b19
Autor:
Melissa Alsina, Madhav Dhodapkar, Jesus Berdeja, Krina Patel, Shambavi Richard, Ravi Vij, Xavier Leleu, Daniel Egan, P. Leif Bergsagel, Reshef Ran, Saad Z Usmani, Anna Truppel-Hartmann, Debashree Basudhar, Ethan Thompson, Xirong Zheng, Xiaobo Zhong, Chiara Greggio, Mihaela Popa Mckiver, Marlene Carrasco Alfonso, David Siegel
Publikováno v:
HemaSphere, Vol 7, p e90596a3 (2023)
Externí odkaz:
https://doaj.org/article/6236526bdbd74b7b92eb7a5ad306efce
Autor:
Marie-France Gagnon, Shulan Tian, Susan Geyer, Neeraj Sharma, Celine M. Vachon, Yael Kusne, P. Leif Bergsagel, A. Keith Stewart, S. Vincent Rajkumar, Shaji Kumar, Sikander Ailawadhi, Linda B. Baughn
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 7, Pp 1-5 (2022)
Externí odkaz:
https://doaj.org/article/ff5dae072f2d408a8873dff9379bf208
Autor:
Josh N. Vo, Yi-Mi Wu, Jeanmarie Mishler, Sarah Hall, Rahul Mannan, Lisha Wang, Yu Ning, Jin Zhou, Alexander C. Hopkins, James C. Estill, Wallace K. B. Chan, Jennifer Yesil, Xuhong Cao, Arvind Rao, Alexander Tsodikov, Moshe Talpaz, Craig E. Cole, Jing C. Ye, Multiple Myeloma Research Consortium, P. Leif Bergsagel, Daniel Auclair, Hearn Jay Cho, Dan R. Robinson, Arul M. Chinnaiyan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The genetic factors involved in disease progression and drug resistance in multiple myeloma (MM) are varied and complex. Here, genomic and transcriptomic profiling of 511 relapsed and refractory MM patients reveals genetic alterations in several onco
Externí odkaz:
https://doaj.org/article/f655f451b78e4e7097fa8cd313e2e43d
Autor:
Mark Bustoros, Shankara Anand, Romanos Sklavenitis-Pistofidis, Robert Redd, Eileen M. Boyle, Benny Zhitomirsky, Andrew J. Dunford, Yu-Tzu Tai, Selina J. Chavda, Cody Boehner, Carl Jannes Neuse, Mahshid Rahmat, Ankit Dutta, Tineke Casneuf, Raluca Verona, Efstathis Kastritis, Lorenzo Trippa, Chip Stewart, Brian A. Walker, Faith E. Davies, Meletios-Athanasios Dimopoulos, P. Leif Bergsagel, Kwee Yong, Gareth J. Morgan, François Aguet, Gad Getz, Irene M. Ghobrial
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Existing clinical models cannot fully capture smoldering multiple myeloma (SMM) heterogeneity. Here, integration of 42 genetic alterations from 214 SMM patients using an unsupervised binary matrix factorization clustering approach results in the iden
Externí odkaz:
https://doaj.org/article/078805a3b909435fb477a229095a08ed
Autor:
Erin W. Meermeier, P. Leif Bergsagel
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Multiple myeloma is a hematologic malignancy of plasma cells that manifests with bone marrow tumors causing lytic bone lesions. Autologous stem cell transplantation (ASCT) after high-dose chemotherapy and followed by prolonged maintenance therapy wit
Externí odkaz:
https://doaj.org/article/6ed4dd66c25649909f9978f0de61f952
Autor:
Rodrigo Fonseca, Mariano Arribas, Julia E. Wiedmeier-Nutor, Yael N. Kusne, Miguel González Vélez, Heidi E. Kosiorek, Richard (Duke) J. Butterfield, Ilan R. Kirsch, Joseph R. Mikhael, A. Keith Stewart, Craig Reeder, Jeremy Larsen, P. Leif Bergsagel, Rafael Fonseca
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/aa22a42a5d1a406a922103be492b5a69