Zobrazeno 1 - 10
of 1 423
pro vyhledávání: '"P. Le Brun"'
Autor:
Ai Vu Hong, Laurence Suel, Eva Petat, Auriane Dubois, Pierre-Romain Le Brun, Nicolas Guerchet, Philippe Veron, Jérôme Poupiot, Isabelle Richard
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Current adeno-associated virus (AAV) gene therapy using nature-derived AAVs is limited by non-optimal tissue targeting. In the treatment of muscular diseases (MD), high doses are often required but can lead to severe adverse effects. Here, w
Externí odkaz:
https://doaj.org/article/2e8bc0e4254344a1a716b976440ae501
Autor:
Lucie Thorel, Jordane Divoux, Justine Lequesne, Guillaume Babin, Pierre-Marie Morice, Romane Florent, Guillaume Desmartin, Lucie Lecouflet, Chloé Marde Alagama, Alexandra Leconte, Bénédicte Clarisse, Mélanie Briand, Roman Rouzier, Léopold Gaichies, Sandrine Martin-Françoise, Jean-François Le Brun, Christophe Denoyelle, Nicolas Vigneron, Corinne Jeanne, Cécile Blanc-Fournier, Raphaël Leman, Dominique Vaur, Martin Figeac, Matthieu Meryet-Figuiere, Florence Joly, Louis-Bastien Weiswald, Laurent Poulain, Enora Dolivet
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background Ovarian cancer is the first cause of death from gynecological malignancies mainly due to development of chemoresistance. Despite the emergence of PARP inhibitors, which have revolutionized the therapeutic management of some of the
Externí odkaz:
https://doaj.org/article/088b590c02d14c37987eaddfddc2217f
Autor:
Pascale Bémer, Alexandra Aubry, Frédéric Schramm, Christelle Koebel, Hélène Revillet, Virginie Baltes, Cécile Le Brun, Pascal Chazerain, Valérie Zeller, Farida Hamdad, Philippe C. Morand, Aurélie Guillouzouic, Caroline Piau, Anne-Laure Roux, Sarah Soueges, Christian Martin, Alice Gaudart, Sophie Hüssler, Vincent Fihman, Anne Carricajo, Christelle Guillet Caruba, Julien Bador, Frédéric-Antoine Dauchy, Hervé Dutronc, Carole Vignals, Olivia Peuchant
Publikováno v:
International Journal of Infectious Diseases, Vol 146, Iss , Pp 107122- (2024)
Objectives: Nontuberculous mycobacteria (NTM) bone and joint infections (BJIs) are uncommon. We evaluated the characteristics of BJIs and identified differences according to immune status. Methods: We performed a multicenter retrospective study in Fr
Externí odkaz:
https://doaj.org/article/16b01f28625f487887c934d57fc9f88b
Autor:
Paolo Olivieri, Moritz Klabes, Jason C. Crack, Angelika Lehmann, Sophie P. Bennett, Nick E. Le Brun, Silke Leimkühler
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT All sulfur transfer pathways generally have in common an l-cysteine desulfurase as the initial sulfur-mobilizing enzyme, which serves as a sulfur donor for the biosynthesis of numerous sulfur-containing biomolecules in the cell. In Escherich
Externí odkaz:
https://doaj.org/article/0f7a42399e5d4ba7bfb2e37cbde98729
Autor:
Mei-Ling Han, Yasser Alsaadi, Jinxin Zhao, Yan Zhu, Jing Lu, Xukai Jiang, Wendong Ma, Nitin A. Patil, Rhys A. Dunstan, Anton P. Le Brun, Hasini Wickremasinghe, Xiaohan Hu, Yimin Wu, Heidi H. Yu, Jiping Wang, Christopher K. Barlow, Phillip J. Bergen, Hsin-Hui Shen, Trevor Lithgow, Darren J. Creek, Tony Velkov, Jian Li
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114410- (2024)
Summary: Polymyxins are often the only effective antibiotics against the “Critical” pathogen Acinetobacter baumannii. Worryingly, highly polymyxin-resistant A. baumannii displaying dependence on polymyxins has emerged in the clinic, leading to di
Externí odkaz:
https://doaj.org/article/ecbb468e0c314b388fb60a1edfa978ee
Autor:
Carolina Carlisle, Brandon T. Metzger, Nathan L. Tintle, Kristine Polley, Kristina H. Jackson, Sara Le Brun-Blashka, Jody Griffiths, William S. Harris
Publikováno v:
Animals, Vol 14, Iss 21, p 3108 (2024)
This study in dogs had two objectives: first, to determine whether a daily supplement of marine omega-3 (EPA and DHA) would (1) increase red blood cell EPA + DHA levels (i.e., the Omega-3 Index derived from dried blood spot analysis) and (2) impact h
Externí odkaz:
https://doaj.org/article/48cf0ddb9a4540b8a50204c2404287b0
Autor:
Nicoletta Zedda, Katie Meheux, Jens Blöcher, Yoan Diekmann, Alexander V. Gorelik, Martin Kalle, Kevin Klein, Anna-Lena Titze, Laura Winkelbach, Elise Naish, Laurent Brou, François Valotteau, Foni Le Brun-Ricalens, Joachim Burger, Maxime Brami
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Joint inhumations of adults and children are an intriguing aspect of the shift from collective to single burial rites in third millennium BC Western Eurasia. Here, we revisit two exceptional Beaker period adult–child graves using ancient D
Externí odkaz:
https://doaj.org/article/e4be52af7c414886b30e221eda8ac6e5
Autor:
Clairelyne Dupin, Solène Valéry, Laurent Guilleminault, Gilles Devouassoux, Marine Merveilleau, Maud Russier, Gisèle Mourin, Johana Pradelli, Philippe Bonniaud, Mathilde Le Brun, Esther Ebstein, Pierre-Antoine Juge, Agnès Lillo-Lelouet, Camille Taillé
Publikováno v:
ERJ Open Research, Vol 10, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/c33d024efbb940d499fcc7df4e710e94
Autor:
Sushanth Gudlur, Filipe Viana Ferreira, Javier Shu Ming Ting, Carmen Domene, Syed Maricar, Anton P. Le Brun, Nageshwar Yepuri, Michael Moir, Robert Russell, Tamim Darwish, Ali Miserez, Marité Cárdenas
Publikováno v:
Frontiers in Soft Matter, Vol 3 (2024)
Peptide-based liquid droplets (coacervates) produced by spontaneous liquid-liquid phase separation (LLPS), have emerged as a promising class of drug delivery systems due to their high entrapping efficiency and the simplicity of their formulation. How
Externí odkaz:
https://doaj.org/article/e7f747c19c1e4446a35d005be56c212d
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