Výsledky vyhledávání - "P. L. Podolin"

Inhibition of contact sensitivity in human CD4+transgenic mice by human CD4-specific monoclonal antibodies: CD4+T-cell depletion is not required

Autor: A. Truneh, E. F. Webb, Don E. Griswold, P. L. Podolin, M.P. Reddy

Publikováno v: Immunology. 99:287-295

Summary Clenoliximab and keliximab are monkey/human chimeric monoclonal antibodies (mAbs) of the immunoglobulin G4 (IgG4) and IgG1 isotypes, respectively, that recognize the same epitope on human CD4. The two mAbs possess identical idiotypes and exhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cda878d77170c0acf1b28bc61ce6741a
https://doi.org/10.1046/j.1365-2567.2000.00946.x

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Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1

Autor: P L Podolin, P Denny, C J Lord, N J Hill, J A Todd, L B Peterson, L S Wicker, P A Lyons

Publikováno v: The Journal of Immunology. 159:1835-1843

The development of autoimmune diabetes in the nonobese diabetic (NOD) mouse is under the control of multiple insulin-dependent diabetes (Idd) genes. The Idd3 gene, originally defined as a broad peak of linkage on mouse chromosome 3, was subsequently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b20acee864789046c85d50d3f09bde32
https://doi.org/10.4049/jimmunol.159.4.1835

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The kinetics of vimentin RNA and protein expression in interleukin 2-stimulated T lymphocytes

Autor: Michael B. Prystowsky, P L Podolin

Publikováno v: Journal of Biological Chemistry. 266:5870-5875

In this paper, we examine the regulation of vimentin expression during interleukin 2-induced proliferation of the cloned helper T cell line, L2. We observe a 10-20-fold increase in steady-state vimentin RNA that is accompanied by a 14-fold increase i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb5b86e01bcfe8e5d0afcd6d6e285fc1
https://doi.org/10.1016/s0021-9258(19)67678-7

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cDNA cloning and characterization of interleukin 2-induced genes in a cloned T helper lymphocyte

Autor: P L Podolin, Daniel E. Sabath, P. G. Comber, Michael B. Prystowsky

Publikováno v: Journal of Biological Chemistry. 265:12671-12678

Clonal expansion of antigen-specific lymphocytes is an important aspect of the immune response. Interleukin 2 (IL2) is largely responsible for the amplification of antigen-specific T cells. In this study, the changes in gene expression accompanying i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a3dfc178de71ca759fc1e5658972b0c
https://doi.org/10.1016/s0021-9258(19)38396-6

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Modulation of human monocyte activities by tranilast, SB 252218, a compound demonstrating efficacy in restenosis

Autor: E A, Capper, A K, Roshak, B J, Bolognese, P L, Podolin, T, Smith, D L, Dewitt, K M, Anderson, L A, Marshall

Publikováno v: The Journal of pharmacology and experimental therapeutics. 295(3)

Tranilast (SB 252218) is a compound initially identified as an anti-atopic agent. Recently the compound has demonstrated clear beneficial effects in animal models of restenosis. Here we confirm tranilast has broad and profound effects on human monocy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::af83dac0c4339c600f89f907a46076b0
https://pubmed.ncbi.nlm.nih.gov/11082441

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