Zobrazeno 1 - 10
of 32
pro vyhledávání: '"P. L. M. van Giersbergen"'
Autor:
E. Fuseau, E. Neuhart, C. Krezel, Pierre Gueret, P. L. M. van Giersbergen, S. Combe, M. Petitou
Publikováno v:
European Journal of Clinical Pharmacology. 72:1041-1050
EP217609 is a parenteral antithrombotic compound combining in one molecule an indirect anti-factor Xa inhibitor, a direct thrombin active site inhibitor and a biotin moiety. The aim of the study is to investigate the safety, pharmacokinetics and phar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98d24b90ff1663cd7cf51659726f709
https://doi.org/10.1007/s00228-016-2077-2
https://doi.org/10.1007/s00228-016-2077-2
Publikováno v:
Journal of Thrombosis and Haemostasis. 12:24-33
Summary Background EP42675 is a first-in-class, synthetic, parenteral, anticoagulant combining in a single molecule a direct thrombin inhibitor and an indirect factor Xa(FXa) inhibitor. Objectives To investigate the safety, pharmacokinetics, and phar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371a93c95035cfe028eba04862e126b6
https://doi.org/10.1111/jth.12453
https://doi.org/10.1111/jth.12453
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 47:169-177
Objective In this study, the distribution, metabolism and excretion of the endothelin receptor antagonist clazosentan were investigated. Subjects and methods 4 healthy male subjects received an intravenous 3-h infusion at a rate of 0.2 mg/kg/h of 14C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e3e78c7e978a98874c91c18803ed7b
https://doi.org/10.5414/cpp47169
https://doi.org/10.5414/cpp47169
Inhibitory and Inductive Effects of Rifampin on the Pharmacokinetics of Bosentan in Healthy Subjects
Publikováno v:
Clinical Pharmacology & Therapeutics. 81:414-419
This study was conducted to investigate the effect of rifampin on the pharmacokinetics of bosentan. Healthy male subjects received bosentan 125 mg b.i.d. for 6.5 days in the presence or absence of rifampin 600 mg once a day. In vitro experiments were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bbc9be4dd9411f207859e2bfd29c40
https://doi.org/10.1038/sj.clpt.6100075
https://doi.org/10.1038/sj.clpt.6100075
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 345:51-56
Neuropeptide K (NPK) and neuropeptide gamma (NP gamma) are two endogenous N-terminally extended forms of neurokinin A (NKA). Here, we compared their effects with those of NKA on 125I-NKA binding, phosphatidylinositol (PI) turnover and smooth muscle c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e32a155c0dc7ea5c9b165322d8da19
https://doi.org/10.1007/bf00175469
https://doi.org/10.1007/bf00175469
Publikováno v:
Annals of the New York Academy of Sciences. 632:370-373
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1d0c6fe9151c8e5228c13a6a01fb9d
https://doi.org/10.1111/j.1749-6632.1991.tb33127.x
https://doi.org/10.1111/j.1749-6632.1991.tb33127.x
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 69:327-333
The effect on blood pressure and heart rate of central administration of dynorphin A(1 – 13) and of β-, γ-, and α-endorphin related peptides was studied in urethane-anesthetized rats. Intracerebroventricular (i.c.v., 0.1 – 10 μg) administrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d26b9a2df8162ac926c833985388751
https://doi.org/10.1139/y91-050
https://doi.org/10.1139/y91-050
Autor:
P. L. M. Van Giersbergen, Henry I. Yamamura, Alden K. Henderson, S. A. Shatzer, Josephine Lai, Shigetada Nakanishi, Stephen H. Buck
Publikováno v:
Proceedings of the National Academy of Sciences. 88:1661-1665
Membranes isolated from a murine fibroblast B82 cell line (SKLKB82#3) transfected with the bovine stomach cDNA pSKR56S exhibited binding of [His(125I)1]neurokinin A (125I-NKA) to a single population of sites with a Bmax of 147 fmol/mg of protein and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96fd6d9392301db6fdc6bf34bde68319
https://doi.org/10.1073/pnas.88.5.1661
https://doi.org/10.1073/pnas.88.5.1661
Autor:
S. Weidauer, F. Ringel, P. L. M. Van Giersbergen, Peter Schmiedek, B. Meyer, Claudius Thomé, V. Breu, Jasper Dingemanse, Peter Vajkoczy, Andreas Raabe
Publikováno v:
Acta Neurochirurgica Supplement ISBN: 9783211757178
The objective of this study was to evaluate the pharmacokinetics of clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage (aSAH) intravenous. Blood samples were taken at different time points during and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd675db648ca3575098ec45b90cb5b98
https://doi.org/10.1007/978-3-211-75718-5_24
https://doi.org/10.1007/978-3-211-75718-5_24
Publikováno v:
Acta Neurochirurgica Supplement ISBN: 9783211757178
Background The objective of this study was firstly to evaluate a possible pharmacodynamic interaction between clazosentan, an endothelin receptor antagonist, and nimodipine in healthy subjects. Secondly, the objective was to assess the pharmacokineti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c1bd3c28cd84f49ae03a1c2fe197215
https://doi.org/10.1007/978-3-211-75718-5_25
https://doi.org/10.1007/978-3-211-75718-5_25