Zobrazeno 1 - 10
of 172
pro vyhledávání: '"P. L. Jacobs"'
Autor:
Rory Boyle, Diana L. Townsend, Hannah M. Klinger, Catherine E. Scanlon, Ziwen Yuan, Gillian T. Coughlan, Mabel Seto, Zahra Shirzadi, Wai-Ying Wendy Yau, Roos J. Jutten, Christoph Schneider, Michelle E. Farrell, Bernard J. Hanseeuw, Elizabeth C. Mormino, Hyun-Sik Yang, Kathryn V. Papp, Rebecca E. Amariglio, Heidi I. L. Jacobs, Julie C. Price, Jasmeer P. Chhatwal, Aaron P. Schultz, Michael J. Properzi, Dorene M. Rentz, Keith A. Johnson, Reisa A. Sperling, Timothy J. Hohman, Michael C. Donohue, Rachel F. Buckley, for the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-16 (2024)
Abstract Background Leveraging Alzheimer’s disease (AD) imaging biomarkers and longitudinal cognitive data may allow us to establish evidence of cognitive resilience (CR) to AD pathology in-vivo. Here, we applied latent class mixture modeling, adju
Externí odkaz:
https://doaj.org/article/533e6b89a4fd4deeb58b8bf4d29de93c
Autor:
Nina Engels-Domínguez, Elouise A. Koops, Stephanie Hsieh, Emma E. Wiklund, Aaron P. Schultz, Joost M. Riphagen, Prokopis C. Prokopiou, Bernard J. Hanseeuw, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson, Heidi I. L. Jacobs
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background Autopsy work indicates that the widely-projecting noradrenergic pontine locus coeruleus (LC) is among the earliest regions to accumulate hyperphosphorylated tau, a neuropathological Alzheimer’s disease (AD) hallmark. This early
Externí odkaz:
https://doaj.org/article/1a2a23bb5bfe4f028d41e04abb34676d
Autor:
Zeliha Yalçin, Shiu Yeung Lam, Marieke H. Peuscher, Jaco van der Torre, Sha Zhu, Prasanna V. Iyengar, Daniel Salas-Lloret, Inge de Krijger, Nathalie Moatti, Ruben van der Lugt, Mattia Falcone, Aurora Cerutti, Onno B. Bleijerveld, Liesbeth Hoekman, Román González-Prieto, Jacqueline J. L. Jacobs
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Maintenance of genome integrity requires tight control of DNA damage response (DDR) signalling and repair, with phosphorylation and ubiquitination representing key elements. How these events are coordinated to achieve productive DNA repair r
Externí odkaz:
https://doaj.org/article/5904fb9cf15e4ea0bcf5f618e256368f
Tau propagation in the brain olfactory circuits is associated with smell perception changes in aging
Autor:
Ibai Diez, Laura Ortiz-Terán, Thomas S. C. Ng, Mark W. Albers, Gad Marshall, William Orwig, Chan-mi Kim, Elisenda Bueichekú, Victor Montal, Jonas Olofsson, Patrizia Vannini, Georges El Fahkri, Reisa Sperling, Keith Johnson, Heidi I. L. Jacobs, Jorge Sepulcre
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The direct access of olfactory afferents to memory-related cortical systems has inspired theories about the role of the olfactory pathways in the development of cortical neurodegeneration in Alzheimer’s disease (AD). In this study, we used
Externí odkaz:
https://doaj.org/article/53baab9f774f44ed85ed879dfc0ad4b7
Autor:
Shuai Yan, Anna Santoro, Micah J. Niphakis, Antonio M. Pinto, Christopher L. Jacobs, Rasheed Ahmad, Radu M. Suciu, Bryan R. Fonslow, Rachel A. Herbst-Graham, Nhi Ngo, Cassandra L. Henry, Dylan M. Herbst, Alan Saghatelian, Barbara B. Kahn, Evan D. Rosen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Obesity-induced inflammation causes metabolic dysfunction, but the mechanisms remain elusive. Here we show that the innate immune transcription factor interferon regulatory factor (IRF3) adversely affects glucose homeostasis through inductio
Externí odkaz:
https://doaj.org/article/85b643d7bcf449cfb95b22f8c588eacb
Autor:
Annemie M W J Schols, Anke H Maitland-van der Zee, Joop P van den Bergh, Sebastiaan Holverda, Esther J Nossent, Els J M Weersink, Marianne A van de Pol, Firdaus A A Mohamed Hoesein, Lisanne T Schuurman, Ivo van der Lee, Jelle M Blankestijn, Mahmoud I Abdel-Aziz, Nadia Baalbaki, Somayeh Bazdar, Inés Beekers, Rosanne J H C G Beijers, Lizan D Bloemsma, Merel E B Cornelissen, Debbie Gach, Laura Houweling, John J L Jacobs, Reneé Jonker, Paulien M A Linders, Lieke C E Noij, Daphne W Schaminee, Brigitte Sondermeijer, J J Miranda Geelhoed, Yolanda de Wit-van Wijck
Publikováno v:
BMJ Open Respiratory Research, Vol 11, Iss 1 (2024)
Background Four months after SARS-CoV-2 infection, 22%–50% of COVID-19 patients still experience complaints. Long COVID is a heterogeneous disease and finding subtypes could aid in optimising and developing treatment for the individual patient.Meth
Externí odkaz:
https://doaj.org/article/08cab7016402442e9e9b869081c263bd
Autor:
Stefano Nardone, Roberto De Luca, Antonino Zito, Nataliya Klymko, Dimitris Nicoloutsopoulos, Oren Amsalem, Cory Brannigan, Jon M. Resch, Christopher L. Jacobs, Deepti Pant, Molly Veregge, Harini Srinivasan, Ryan M. Grippo, Zongfang Yang, Mark L. Zeidel, Mark L. Andermann, Kenneth D. Harris, Linus T. Tsai, Elda Arrigoni, Anne M. J. Verstegen, Clifford B. Saper, Bradford B. Lowell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract The “dorsal pons”, or “dorsal pontine tegmentum” (dPnTg), is part of the brainstem. It is a complex, densely packed region whose nuclei are involved in regulating many vital functions. Notable among them are the parabrachial nucleus,
Externí odkaz:
https://doaj.org/article/f281b415638047cf935491423b9003e6
Autor:
Fatma Jebri, Meric Srokosz, Dionysios E. Raitsos, Zoe L. Jacobs, Alejandra Sanchez-Franks, Ekaterina Popova
Publikováno v:
Communications Earth & Environment, Vol 5, Iss 1, Pp 1-14 (2024)
Abstract Somali upwelling is the fifth largest upwelling globally with high productivity, attracting tuna migratory species. A key control on the upwelling productivity is its interaction with one of the world’s largest oceanic eddies, the Great Wh
Externí odkaz:
https://doaj.org/article/6d2e9d0263474bba9fd327ae5d264f70
Autor:
Eric L. Eisenstein, Kevin D. Hill, Nancy Wood, Jerry L. Kirchner, Kevin J. Anstrom, Christopher B. Granger, Sunil V. Rao, H. Scott Baldwin, Jeffrey P. Jacobs, Marshall L. Jacobs, Prince J. Kannankeril, Eric M. Graham, Sean M. O'Brien, Jennifer S. Li
Publikováno v:
Contemporary Clinical Trials Communications, Vol 38, Iss , Pp 101257- (2024)
Background: Registry-based trials have the potential to reduce randomized clinical trial (RCT) costs. However, observed cost differences also may be achieved through pragmatic trial designs. A systematic comparison of trial costs across different des
Externí odkaz:
https://doaj.org/article/7912ef2ef50e4a909f9255670edbac5b
Autor:
R. Yombo Phaka, A. Merlaud, G. Pinardi, M. M. Friedrich, M. Van Roozendael, J.-F. Müller, T. Stavrakou, I. De Smedt, F. Hendrick, E. Dimitropoulou, R. Bopili Mbotia Lepiba, E. Phuku Phuati, B. L. Djibi, L. Jacobs, C. Fayt, J.-P. Mbungu Tsumbu, E. Mahieu
Publikováno v:
Atmospheric Measurement Techniques, Vol 16, Pp 5029-5050 (2023)
We present a database of MAX-DOAS (Multi-AXis Differential Optical Absorption Spectroscopy) ground-based observations of NO2 and H2CO tropospheric vertical column densities (VCDtropo) performed for the first time in the city of Kinshasa. These measur
Externí odkaz:
https://doaj.org/article/466addab4011447aaf3aaae86a78a033