Zobrazeno 1 - 10
of 31
pro vyhledávání: '"P. L. Hordijk"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Iron is hypothesized to be one of the contributors to cardiovascular disease and its levels in the circulation may correlate with cardiovascular risk. The aim of this study is to investigate the mechanisms that underlie the effects of iron o
Externí odkaz:
https://doaj.org/article/d9c946d39f454f2086e1d48f86aceb0e
Autor:
Nicole A. M. Dekker, Anoek L. I. van Leeuwen, Matijs van Meurs, Jill Moser, Jeannette E. Pankras, Nicole N. van der Wel, Hans W. Niessen, Marc G. Vervloet, Alexander B. A. Vonk, Peter L. Hordijk, Christa Boer, Charissa E. van den Brom
Publikováno v:
Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-19 (2021)
Abstract Background Acute kidney injury is a severe complication following cardiopulmonary bypass (CPB) and is associated with capillary leakage and microcirculatory perfusion disturbances. CPB-induced thrombin release results in capillary hyperperme
Externí odkaz:
https://doaj.org/article/7871f73c22804178aed75e7f5ff74ae3
Autor:
Anne-Eva van der Wijk, Theodosia Georgakopoulou, Jisca Majolée, Jan S. M. van Bezu, Miesje M. van der Stoel, Bert J. van het Hof, Helga E. de Vries, Stephan Huveneers, Peter L. Hordijk, Erik N. T. P. Bakker, Ed van Bavel
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-14 (2020)
Abstract Considering its intolerance to ischemia, it is of critical importance for the brain to efficiently process microvascular occlusions and maintain tissue perfusion. In addition to collateral microvascular flow and enzymatic degradation of embo
Externí odkaz:
https://doaj.org/article/41264de83db645b6a72d2179d05993f2
Autor:
Fabienne Podieh, Peter L. Hordijk
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Cullin3-based ubiquitin E3 ligases induce ubiquitination of substrates leading to their proteasomal or lysosomal degradation. BTB proteins serve as adaptors by binding to Cullin3 and recruiting substrate proteins, which enables specific recognition o
Externí odkaz:
https://doaj.org/article/f4f3522009924763a47164c084d8982d
Autor:
Nicole A. M. Dekker, Anoek L. I. van Leeuwen, Willem W. J. van Strien, Jisca Majolée, Robert Szulcek, Alexander B. A. Vonk, Peter L. Hordijk, Christa Boer, Charissa E. van den Brom
Publikováno v:
Critical Care, Vol 23, Iss 1, Pp 1-10 (2019)
Abstract Background Endothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and postoperative complications after cardiac surgery. We investigated the postoperative course of renal a
Externí odkaz:
https://doaj.org/article/cc5db07a0166413e81447272e7a71363
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254386 (2021)
Signaling by the Rho GTPase Rac1 is key to the regulation of cytoskeletal dynamics, cell spreading and adhesion. It is widely accepted that the inactive form of Rac1 is bound by Rho GDI, which prevents Rac1 activation and Rac1-effector interactions.
Externí odkaz:
https://doaj.org/article/d63de637915a493c937ec2973bb473a3
Autor:
Niloufar Mosaddeghzadeh, Neda S. Kazemein Jasemi, Jisca Majolée, Si-Cai Zhang, Peter L. Hordijk, Radovan Dvorsky, Mohammad Reza Ahmadian
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 22, p 12493 (2021)
Three decades of research have documented the spatiotemporal dynamics of RHO family GTPase membrane extraction regulated by guanine nucleotide dissociation inhibitors (GDIs), but the interplay of the kinetic mechanism and structural specificity of th
Externí odkaz:
https://doaj.org/article/016abdbc02aa459eb551752890f5a0da
Autor:
Yvonne L. Dorland, Tsveta S. Malinova, Anne-Marieke D. van Stalborch, Adam G. Grieve, Daphne van Geemen, Nicolette S. Jansen, Bart-Jan de Kreuk, Kalim Nawaz, Jeroen Kole, Dirk Geerts, René J. P. Musters, Johan de Rooij, Peter L. Hordijk, Stephan Huveneers
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
Cell-cell adhesion of endothelial tissue, mediated by the adhesion molecule VE-cadherin, is tightly regulated. Here the authors show that the F-BAR domain protein pacsin2 is recruited to the trailing end of mechanically unbalanced Focal Adherens Junc
Externí odkaz:
https://doaj.org/article/39489597f19d45109896f9a7f11b9fb8
Autor:
Marc Vila Cuenca, Evelina Ferrantelli, Elisa Meinster, Stephan M. Pouw, Igor Kovačević, Renee X. de Menezes, Hans W. Niessen, Robert H.J. Beelen, Peter L. Hordijk, Marc G. Vervloet
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 17 (2018)
Background Dysfunctional endothelium may contribute to the development of cardiovascular complications in chronic kidney disease (CKD). Supplementation with active vitamin D has been proposed to have vasoprotective potential in CKD, not only by direc
Externí odkaz:
https://doaj.org/article/6125b4404ece47069e715d53250e83b3
Autor:
Joana Amado-Azevedo, Renee X de Menezes, Geerten P van Nieuw Amerongen, Victor W M van Hinsbergh, Peter L Hordijk
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0201231 (2018)
Thrombin and other inflammatory mediators may induce vascular permeability through the disruption of adherens junctions between adjacent endothelial cells. If uncontrolled, hyperpermeability leads to an impaired barrier, fluid leakage and edema, whic
Externí odkaz:
https://doaj.org/article/042b282c839c4993a979d1b359e5f8cd