Zobrazeno 1 - 10 of 10 pro vyhledávání: '"P. L. DURETTE"'
1
Conformation of MeAla6-cyclosporin A by NMR. Relationship of sidechain orientation of the MeBmt-1, MeLeu-9, and MeLeu-10 residues to immunosuppressive activity
Autor: P R, Gooley, P L, Durette, J, Boger, I M, Armitage
Publikováno v: International journal of peptide and protein research. 37(5)
MeAla6-cyclosporin A (MeAla6-CsA) is a unique CsA analog that shows weak immunosuppressive activity and yet binds strongly to the proposed cytosolic protein receptor, cyclophilin (CyP). Preliminary 1H NMR data showed significant chemical shift differ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8461ca17122dcc850529bef2a3861e96
https://pubmed.ncbi.nlm.nih.gov/1917291
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2
Pharmacology of the dual inhibitor of cyclooxygenase and 5-lipoxygenase 3-hydroxy-5-trifluoromethyl-N-(2-(2-thienyl)-2-phenyl-ethenyl)-benzo (b)thiophene-2-carboxamide
Autor: P J, Bailey, A L, Dallob, D L, Allison, R L, Anderson, T, Bach, P L, Durette, K M, Hand, S L, Hopple, S, Luell, R, Meurer
Publikováno v: Arzneimittel-Forschung. 38(3)
3-Hydroxy-5-trifluoromethyl-N-(2-(2-thienyl)-2-phenyl-ethenyl)- benzo (b) thiophene-2-carboxamide (L-652,343) is an inhibitor of cyclooxygenase and 5-lipoxygenase in vitro and inhibits the synthesis of the products of both these pathways in whole cel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ddb00921753e2fc56b601b263bf3dd6
https://pubmed.ncbi.nlm.nih.gov/3132928
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6
A study of the correlation between cyclophilin binding and in vitro immunosuppressive activity of cyclosporine A and analogues
Autor: P L, Durette, J, Boger, F, Dumont, R, Firestone, R A, Frankshun, S L, Koprak, C S, Lin, M R, Melino, A A, Pessolano, J, Pisano
Publikováno v: Transplantation proceedings. 20(2 Suppl 2)
In order to establish whether CyP is the pharmacologically relevant CsA receptor, the CyP binding v immunosuppressive activity was measured for an extensive, structurally varied group of CsA analogues. Overall, CyP binding was found to parallel immun
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b7f46afd071e272afe79e724a494967
https://pubmed.ncbi.nlm.nih.gov/2966482
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