Zobrazeno 1 - 10
of 65
pro vyhledávání: '"P. L. Bergsagel"'
Autor:
Joseph R. Mikhael, Yi Lin, Martha Q. Lacy, R Fonseca, Asher Chanan-Khan, Morie A. Gertz, Wilson I. Gonsalves, Shaji Kumar, Betsy LaPlant, David Dingli, Robert A. Kyle, Steven Russell, Francis K. Buadi, Suzanne R. Hayman, P L Bergsagel, Alexander Keith Stewart, Ronald S. Go, Nelson Leung, Taxiarchis Kourelis, Taimur Sher, Prashant Kapoor, Angela Dispenzieri, K M Laumann, Sikander Ailawadhi, John A. Lust, Vivek Roy, S V Rajkumar, Craig B. Reeder
Publikováno v:
Leukemia. 32:719-728
Despite therapeutic advances, multiple myeloma remains incurable, with limited options for patients with refractory disease. We conducted a large, multi-cohort clinical trial testing various doses and treatment schedules of pomalidomide and dexametha
Autor:
P L Bergsagel, S. Galvan, Alessandro Campanella, Maria Teresa Sabrina Bertilaccio, Clara Camaschella, Marta Chesi, Maurilio Ponzoni, Jessica Bordini
Publikováno v:
Leukemia. 31:967-970
Induction of iron excess restricts malignant plasma cells expansion and potentiates bortezomib effect in models of multiple myeloma
Autor:
Daniel L. Riggs, Jonathan J Keats, Victoria M. Garbitt, P L Bergsagel, S Van Wier, K Tamizhmani, Yulia N. Demchenko, Leslie A. Brents, A V Roschke, W. M. Kuehl, Maurizio Affer, W D Chen, Marta Chesi, R Fonseca
Publikováno v:
Leukemia
MYC locus rearrangements-often complex combinations of translocations, insertions, deletions and inversions-in multiple myeloma (MM) were thought to be a late progression event, which often did not involve immunoglobulin genes. Yet, germinal center a
Autor:
Wilson I. Gonsalves, Yi Lin, Morie A. Gertz, Shaji Kumar, Martha Q. Lacy, Praful Ravi, Steven Russell, Angela Dispenzieri, Nelson Leung, Robert A. Kyle, P L Bergsagel, John A. Lust, Ronald S. Go, S V Rajkumar, Prashant Kapoor, Francis K. Buadi, Jeremy T. Larsen, David Dingli
Publikováno v:
Blood Cancer Journal
We studied 190 patients with smoldering multiple myeloma (SMM) at our institution between 1973 and 2014. Evolving change in monoclonal protein level (eMP) was defined as ⩾10% increase in serum monoclonal protein (M) and/or immunoglobulin (Ig) (M/Ig
Autor:
P. L. Bergsagel
Publikováno v:
AACR Education book. 2012:197-201
Autor:
Craig B. Reeder, Jacy Spong, Christine Chen, V H J Zepeda, Suzanne Trudel, Vishal Kukreti, R Fonseca, Joseph R. Mikhael, Brie N. Noble, Nicholas A. Pirooz, Jesus Giovanni Piza, Alexander Keith Stewart, Jose F. Leis, Donna E. Reece, P L Bergsagel, Joseph G. Hentz
Publikováno v:
Leukemia
We have studied a three-drug combination with cyclophosphamide, bortezomib and dexamethasone (CyBorD) on a 28-day cycle in the treatment of newly diagnosed multiple myeloma (MM) patients to assess response and toxicity. The primary endpoint of respon
Autor:
P L Bergsagel, Craig B. Reeder, Farouk Mookadam, Alexander Keith Stewart, Marek Belohlavek, Allison C. Rosenthal, Joseph R. Mikhael, R Fonseca, J Luthi, Klaus Martin Kortüm, Angela Mayo
Publikováno v:
Blood Cancer Journal
Carfilzomib (Cfz) has been associated with an ~5% incidence of unexplained and unpredictable cardiovascular toxicity in clinical trials. We therefore implemented a detailed, prospective, clinical cardiac and renal evaluation of 62 Cfz-treated myeloma
Autor:
Susanna Jacobus, Rafael Fonseca, M. Q. Lacy, P R Greipp, Martin M. Oken, Emily A. Blood, Wee Joo Chng, Gregory J. Ahmann, Syed M. Jalal, Marta Chesi, Morie A. Gertz, P L Bergsagel, Robert A. Kyle, Rafael Santana-Davila, S Van Wier, M. C. Trendle, Kim Henderson, Angela Dispenzieri
Publikováno v:
Leukemia. 20:807-813
Chromosomal hyperdiploidy is the defining genetic signature in 40-50% of myeloma (MM) patients. We characterize hyperdiploid-MM (H-MM) in terms of its clinical and prognostic features in a cohort of 220 H-MM patients entered into clinical trials. Hyp
Autor:
Rafael Santana-Davila, P R Greipp, S Van Wier, Kim Henderson, Martin M. Oken, Marta Chesi, Morie A. Gertz, Robert A. Kyle, Martha Q. Lacy, Rafael Fonseca, Emily A. Blood, P L Bergsagel, A. Hulbert, Wee Joo Chng, Gregory J. Ahmann, Angela Dispenzieri, Syed M. Jalal, Jerry M. Winkler, M. C. Trendle
Publikováno v:
Leukemia Research. 30:266-271
Hyperdiploid and non-hyperdiploid multiple myeloma represents distinct biological entities characterized by different patterns of genetic changes. We sought to determine whether ploidy category (non-hyperdiploid versus hyperdiploid) remains stable ov
Autor:
J L Daggett, Timothy P. Bender, P L Bergsagel, W. M. Kuehl, M S Kulkarni, Michael E. Williams
Publikováno v:
Leukemia. 16:127-134
Multiple myeloma (MM) is a clonal neoplasm of plasma cells which offers an excellent model to study multistep molecular oncogenesis. In 20-25% of primary tumors and cell lines examined, cyclin D1 is overexpressed due to the translocation t(11;14)(q13