Zobrazeno 1 - 10
of 1 088
pro vyhledávání: '"P. Krijger"'
Autor:
Rosbach, Emely, Ammeling, Jonas, Krügel, Sebastian, Kießig, Angelika, Fritz, Alexis, Ganz, Jonathan, Puget, Chloé, Donovan, Taryn, Klang, Andrea, Köller, Maximilian C., Bolfa, Pompei, Tecilla, Marco, Denk, Daniela, Kiupel, Matti, Paraschou, Georgios, Kok, Mun Keong, Haake, Alexander F. H., de Krijger, Ronald R., Sonnen, Andreas F. -P., Kasantikul, Tanit, Dorrestein, Gerry M., Smedley, Rebecca C., Stathonikos, Nikolas, Uhl, Matthias, Bertram, Christof A., Riener, Andreas, Aubreville, Marc
Artificial intelligence (AI)-based decision support systems hold promise for enhancing diagnostic accuracy and efficiency in computational pathology. However, human-AI collaboration can introduce and amplify cognitive biases, such as confirmation bia
Externí odkaz:
http://arxiv.org/abs/2411.01007
Autor:
Thomas A. Kluiver, Yuyan Lu, Stephanie A. Schubert, Lianne J. Kraaier, Femke Ringnalda, Philip Lijnzaad, Jeff DeMartino, Wouter L. Megchelenbrink, Vicky Amo-Addae, Selma Eising, Flavia W. de Faria, Daniel Münter, Marc van de Wetering, Kornelius Kerl, Evelien Duiker, Marius C. van den Heuvel, Vincent E. de Meijer, Ruben H. de Kleine, Jan J. Molenaar, Thanasis Margaritis, Hendrik G. Stunnenberg, Ronald R. de Krijger, József Zsiros, Hans Clevers, Weng Chuan Peng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Hepatoblastoma, the most prevalent pediatric liver cancer, almost always carries a WNT-activating CTNNB1 mutation, yet exhibits notable molecular heterogeneity. To characterize this heterogeneity and identify novel targeted therapies, we per
Externí odkaz:
https://doaj.org/article/e9c310a9ac5d476ba9c8f3c8d25d32c8
Autor:
Rixt S. Bruinsma, Marta F. Fiocco, Wendy W. J. de Leng, Lennart A. Kester, Karin P. S. Langenberg, Godelieve A. M. Tytgat, Max M. van Noesel, Marc H. W. A. Wijnen, Alida F. W. van der Steeg, Ronald R. de Krijger
Publikováno v:
Journal of Molecular Pathology, Vol 5, Iss 3, Pp 304-318 (2024)
ALK is related to poor survival in neuroblastoma patients. We investigated the prognostic relevance of ALK mRNA expression and the relationship with ALK immunohistochemical expression, histological subtype and ALK aberrations. Whole transcriptome seq
Externí odkaz:
https://doaj.org/article/7650c5ee68724d7986d26e5dc5cc04ca
Autor:
Aimée S. R. Westerveld, Pien Roesthuis, Helena J. H. van der Pal, Dorine Bresters, Marc Bierings, Jacqueline Loonen, Andrica C. H. de Vries, Marloes Louwerens, Maria M. W. Koopman, Marry M. van den Heuvel-Eibrink, Margriet van der Heiden-van der Loo, Peter Hoogerbrugge, Geert O. Janssens, Ronald R. de Krijger, Cecile M. Ronckers, Rob Pieters, Leontien C. M. Kremer, Jop C. Teepen
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Acute lymphoblastic leukemia (ALL) survivors are at risk for developing subsequent neoplasms, but there is limited information on long-term risks and risk factors for both subsequent malignant neoplasms (SMNs) and subsequent non-malignant ne
Externí odkaz:
https://doaj.org/article/dd1578a6e4ab4a39aa7be9fb7ad260a1
Autor:
Karina C. Borja Jiménez, Patrick Kemmeren, Marry van den Heuvel-Ebrink, Ronald de Krijger, Martha Grootenhuis, Marita Partanen, Norbert Graf, Shuping Wen, Alexander Leemans, Daniel L. Oberski, Reineke A. Schoot, Johannes H.M. Merks
Publikováno v:
EJC Paediatric Oncology, Vol 4, Iss , Pp 100187- (2024)
Contributing to UNICA4EU’s vision to upscale and wide-scale the application of AI technology to pediatric cancer care, this paper provides guidelines for the development of an AI-based ecosystem and its potential implementation into clinical practi
Externí odkaz:
https://doaj.org/article/38575ec036c6471cbc94b799209508c6
Autor:
Zeena Harakeh, Iris de Hoogh, Anne-Margreeth Krijger-Dijkema, Susanne Berbée, Gino Kalkman, Pepijn van Empelen, Wilma Otten
Publikováno v:
JMIR Formative Research, Vol 8, p e57312 (2024)
BackgroundGiven the multifactorial nature of type 2 diabetes (T2D), health care for this condition would benefit from a holistic approach and multidisciplinary consultation. To address this, we developed the web-based 360-degree (360°) diagnostic to
Externí odkaz:
https://doaj.org/article/eb56b66e21f34bf9af03db2e29d537f8
Autor:
Zeliha Yalçin, Shiu Yeung Lam, Marieke H. Peuscher, Jaco van der Torre, Sha Zhu, Prasanna V. Iyengar, Daniel Salas-Lloret, Inge de Krijger, Nathalie Moatti, Ruben van der Lugt, Mattia Falcone, Aurora Cerutti, Onno B. Bleijerveld, Liesbeth Hoekman, Román González-Prieto, Jacqueline J. L. Jacobs
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Maintenance of genome integrity requires tight control of DNA damage response (DDR) signalling and repair, with phosphorylation and ubiquitination representing key elements. How these events are coordinated to achieve productive DNA repair r
Externí odkaz:
https://doaj.org/article/5904fb9cf15e4ea0bcf5f618e256368f
Autor:
Maria Riedmeier, Sonir Antonini, Clemens Benoit, Cheri L. Deal, Fassnacht Martin, Bonald C. Figueiredo, Elmas Nazli Gonc, Christoph Härtel, Jan Idkowiak, Max Kurlbaum, Ronald de Krijger, Raul C. Ribeiro, Jaydira del Rivero, Paul-Gerhardt Schlegel, Lester D.R. Thompson, Bilgehan Yalcin, Verena Wiegering
Publikováno v:
Pediatric Hematology Oncology Journal, Vol 9, Iss 2, Pp 74-77 (2024)
Background: Mitotane is employed as adjuvant therapy in managing adrenocortical carcinoma in pediatric patients. While various adverse effects, such as estrogen-like manifestations, are well-documented in adults, there is limited knowledge regarding
Externí odkaz:
https://doaj.org/article/c5c6a99c16b6466dae3500b25dbf08f2
Publikováno v:
BMC Health Services Research, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background Youth healthcare has an important role in promoting a healthy lifestyle in young children in order to prevent lifestyle-related health problems. To aid youth healthcare in this task, a new lifestyle screening tool will be develope
Externí odkaz:
https://doaj.org/article/9eb7b1a956764a55920c012643f9c13a
Autor:
Caroline C.C. Hulsker, Maya Schulpen, Annelies M.C. Mavinkurve-Groothuis, Otto Visser, József Zsiros, Marc H.W. Wijnen, Ronald R. de Krijger, Annette H. Bruggink, Leendert H.J. Looijenga, Henrike E. Karim-Kos, Alida F.W. van der Steeg
Publikováno v:
EJC Paediatric Oncology, Vol 3, Iss , Pp 100148- (2024)
Background: Population-based studies assessing long-term patterns of incidence and disease characteristics of germ cell tumors (GCTs) in children are scarce. We investigated incidence and survival trends of malignant extracranial GCTs in children usi
Externí odkaz:
https://doaj.org/article/3d2b227095c7475cb0180235ba227e31