Zobrazeno 1 - 10
of 301
pro vyhledávání: '"P. Krais"'
Autor:
Fumiaki Ito, Ziyuan Li, Leonid Minakhin, Gurushankar Chandramouly, Mrityunjay Tyagi, Robert Betsch, John J. Krais, Bernadette Taberi, Umeshkumar Vekariya, Marissa Calbert, Tomasz Skorski, Neil Johnson, Xiaojiang S. Chen, Richard T. Pomerantz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract DNA polymerase theta (Polθ) is a DNA helicase-polymerase protein that facilitates DNA repair and is synthetic lethal with homology-directed repair (HDR) factors. Thus, Polθ is a promising precision oncology drug-target in HDR-deficient can
Externí odkaz:
https://doaj.org/article/46164b5688fb4f7488433df9b86a86b9
Autor:
Ksenija Nesic, John J. Krais, Yifan Wang, Cassandra J. Vandenberg, Pooja Patel, Kathy Q. Cai, Tanya Kwan, Elizabeth Lieschke, Gwo-Yaw Ho, Holly E. Barker, Justin Bedo, Silvia Casadei, Andrew Farrell, Marc Radke, Kristy Shield-Artin, Jocelyn S. Penington, Franziska Geissler, Elizabeth Kyran, Robert Betsch, Lijun Xu, Fan Zhang, Alexander Dobrovic, Inger Olesen, Rebecca Kristeleit, Amit Oza, Iain McNeish, Gayanie Ratnayake, Nadia Traficante, Australian Ovarian Cancer Study, Anna DeFazio, David D. L. Bowtell, Thomas C. Harding, Kevin Lin, Elizabeth M. Swisher, Olga Kondrashova, Clare L. Scott, Neil Johnson, Matthew J. Wakefield
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-10 (2024)
Abstract PARP inhibitor (PARPi) therapy has transformed outcomes for patients with homologous recombination DNA repair (HRR) deficient ovarian cancers, for example those with BRCA1 or BRCA2 gene defects. Unfortunately, PARPi resistance is common. Mul
Externí odkaz:
https://doaj.org/article/8f0a9b712db94dd79db01d43d570add9
Autor:
William Fried, Mrityunjay Tyagi, Leonid Minakhin, Gurushankar Chandramouly, Taylor Tredinnick, Mercy Ramanjulu, William Auerbacher, Marissa Calbert, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Robert Betsch, John J. Krais, Yifan Wang, Umeshkumar M. Vekariya, John Gordon, George Morton, Tatiana Kent, Tomasz Skorski, Neil Johnson, Wayne Childers, Xiaojiang S. Chen, Richard T. Pomerantz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The DNA damage response (DDR) protein DNA Polymerase θ (Polθ) is synthetic lethal with homologous recombination (HR) factors and is therefore a promising drug target in BRCA1/2 mutant cancers. We discover an allosteric Polθ inhibitor (Pol
Externí odkaz:
https://doaj.org/article/a588334634d94054a3dac469d64b47e7
Autor:
Zheshun Jiang, Romane Person, Thomas Lundh, Daniela Pineda, Malin Engfeldt, Annette M. Krais, Jessika Hagberg, Niklas Ricklund, Ulla Vogel, Anne T. Saber, Martin Tondel, Maria Albin, Karin Broberg
Publikováno v:
Environment International, Vol 190, Iss , Pp 108874- (2024)
Background: Hexavalent chromium (Cr(Ⅵ)) is classified as a group 1 human carcinogen and increases the risk of lung cancer. Non-coding RNAs (ncRNAs) have key regulatory roles in lung cancer, but less is known about their relation to Cr(Ⅵ) exposure
Externí odkaz:
https://doaj.org/article/34c207ce8b5c49d3a5dde34c82b6754e
Autor:
Annachiara Malin Igra, Mercedes Trask, Syed Moshfiqur Rahman, Kristian Dreij, Christian Lindh, Annette M. Krais, Lars-Åke Persson, Anisur Rahman, Maria Kippler
Publikováno v:
Environment International, Vol 189, Iss , Pp 108798- (2024)
Background: In experimental studies, several polycyclic aromatic hydrocarbons (PAHs) have shown endocrine disrupting properties, but very few epidemiological studies have examined their impact on pubertal development and results have been heterogenou
Externí odkaz:
https://doaj.org/article/9aaca4ac73ee4984a7a0e8bf515d8ff0
Autor:
Victoria Drechsel, Stefanie Krais, Katharina Peschke, Michael Ziegler, Heinz-R. Köhler, Rita Triebskorn
Publikováno v:
Environmental Sciences Europe, Vol 36, Iss 1, Pp 1-15 (2024)
Abstract Background Glyphosate is a broad-spectrum, non-selective systemic herbicide with a commonly assumed low potential for accumulation in biota. Nevertheless, glyphosate has been shown to bioaccumulate in the tissues of several organisms. To und
Externí odkaz:
https://doaj.org/article/9aad6ca999f64ada980f894828d8410e
Autor:
John J. Krais, David J. Glass, Ilse Chudoba, Yifan Wang, Wanjuan Feng, Dennis Simpson, Pooja Patel, Zemin Liu, Ryan Neumann-Domer, Robert G. Betsch, Andrea J. Bernhardy, Alice M. Bradbury, Jason Conger, Wei-Ting Yueh, Joseph Nacson, Richard T. Pomerantz, Gaorav P. Gupta, Joseph R. Testa, Neil Johnson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Homologous recombination (HR)-deficiency induces a dependency on DNA polymerase theta (Polθ/Polq)-mediated end joining, and Polθ inhibitors (Polθi) are in development for cancer therapy. BRCA1 and BRCA2 deficient cells are thought to be s
Externí odkaz:
https://doaj.org/article/1134d3c423c24ee9b10823404374aee9
The construction of discontinuous Galerkin (DG) methods for the compressible Euler or Navier-Stokes equations (NSE) includes the approximation of non-linear flux terms in the volume integrals. The terms can lead to aliasing and stability issues in tu
Externí odkaz:
http://arxiv.org/abs/2003.02296
Autor:
Eva Gorrochategui, Marc Le Vee, Habiba Selmi, Anne Gérard, Jade Chaker, Annette M. Krais, Christian Lindh, Olivier Fardel, Cécile Chevrier, Pierre Le Cann, Gary W. Miller, Robert Barouki, Bernard Jégou, Thomas Gicquel, David M. Kristensen, Arthur David
Publikováno v:
Environment International, Vol 181, Iss , Pp 108299- (2023)
Paracetamol/acetaminophen (N-acetyl-p-aminophenol, APAP) is a top selling analgesic used in more than 600 prescription and non-prescription pharmaceuticals. To study efficiently some of the potential undesirable effects associated with increasing APA
Externí odkaz:
https://doaj.org/article/b0e163d6b97d4499a77e2ca8b8f6626a
Autor:
Krais, Nico, Beck, Andrea, Bolemann, Thomas, Frank, Hannes, Flad, David, Gassner, Gregor, Hindenlang, Florian, Hoffmann, Malte, Kuhn, Thomas, Sonntag, Matthias, Munz, Claus-Dieter
High order (HO) schemes are attractive candidates for the numerical solution of multiscale problems occurring in fluid dynamics and related disciplines. Among the HO discretization variants, discontinuous Galerkin schemes offer a collection of advant
Externí odkaz:
http://arxiv.org/abs/1910.02858