Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange

Autor: Sandrine Guillard, Paulina Kolasinska-Zwierz, Judit Debreczeni, Jason Breed, Jing Zhang, Nicolas Bery, Rose Marwood, Jon Tart, Ross Overman, Pawel Stocki, Bina Mistry, Christopher Phillips, Terence Rabbitts, Ronald Jackson, Ralph Minter

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Ras is mutated in many cancers, but so far no drug targeting Ras is in clinical use despite great efforts. Here the authors structurally and functionally characterize a DARPin that potently inhibits the nucleotide exchange of Ras, which might facilit

Externí odkaz: https://doaj.org/article/511b9c0f118d47a5b8dc1ab52f044f6e

A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stress

Autor: Alicia N McMurchy, Przemyslaw Stempor, Tessa Gaarenstroom, Brian Wysolmerski, Yan Dong, Darya Aussianikava, Alex Appert, Ni Huang, Paulina Kolasinska-Zwierz, Alexandra Sapetschnig, Eric A Miska, Julie Ahringer

Publikováno v: eLife, Vol 6 (2017)

Repetitive sequences derived from transposons make up a large fraction of eukaryotic genomes and must be silenced to protect genome integrity. Repetitive elements are often found in heterochromatin; however, the roles and interactions of heterochroma

Externí odkaz: https://doaj.org/article/f96983d48e844817adce32b9757746c9

Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project

Autor: L. Dick, Mark S. Guyer, D. Mecenas, William C. Spencer, Ming Sin Cheung, Sebastian D. Mackowiak, Tao Liu, A. Vielle, Abby F. Dernburg, Mitzi Morris, Bradley I. Arshinoff, Sheldon J. McKay, Amber Leahey, Thea A. Egelhofer, Lukas Habegger, Michael Snyder, Teruaki Takasaki, Roger P. Alexander, Stuart K. Kim, Ashish Agarwal, Ting Han, A. Leo Iniguez, Eric L. Van Nostrand, Gos Micklem, S. Taing, Ekta Khurana, Joel Rozowsky, Beijing Wu, Steven Henikoff, Adrian Carr, Philip Green, Angie S. Hinrichs, A. Muroyama, Jason D. Lieb, Paul Lloyd, Yaniv Lubling, P. Scheid, Kevin Y. Yip, Stefan R. Henz, Chao Cheng, Jiang Du, Mei Zhong, P. Alves, Elicia Preston, Zhi John Lu, Vishal Khivansara, Robert H. Waterston, J. Janette, C. Slightam, Frank J. Slack, David M. Miller, Eo Stinson, Nikolaus Rajewsky, Eran Segal, Jing Leng, Tony Hyman, R. Robilotto, C. Shou, Gunnar Rätsch, Eric C. Lai, Mihail Sarov, X. Shirley Liu, Isabel J. Latorre, A. Chateigner, Francois Gullier, Raymond K. Auerbach, W. James Kent, Sergio Contrino, Jeremy Brouillet, Lincoln Stein, T. Phippen, Andrea Sboner, Marco Mangone, Georg Zeller, Hoang Pham, Mark Gerstein, Michael J. MacCoss, Siew Loon Ooi, Cathleen M. Brdlik, D. Vafeados, Nicole L. Washington, Andreas Rechtsteiner, Peter J. Good, Susan Strome, Galt P. Barber, Kristin C. Gunsalus, John I. Murray, Valerie Reinke, Luke Dannenberg, Masaomi Kato, M. Jensen, X. Feng, John Kim, Kahn Rhrissorrakrai, H. Holster, Kohta Ikegami, Christina M. Whittle, M. Gutwein, Rachel Lyne, Wei Niu, Richard J.H. Smith, LaDeana W. Hillier, P. Kolasinska-Zwierz, Heidi Rosenbaum, Andréa C. Dosé, Xingliang Zhou, Marc D. Perry, Rajkumar Sasidharan, Rebecca F. Lowdon, Arshad Desai, Z. Zha, J. Brennan, Guilin Wang, P. Ruzanov, Brent Ewing, Gennifer E. Merrihew, Kim Rutherford, Reto Gassmann, Elise A. Feingold, Fabio Piano, Julie Ahringer, E. Kephart, Lucas Lochovsky, Sevinc Ercan, Suzanna E. Lewis, Ksenia Voronina, Koon-Kiu Yan, Jorja G. Henikoff, Hyunjin Shin, Hiram Clawson, Ghia Euskirchen

Publikováno v: Science. 330:1775-1787

From Genome to Regulatory Networks For biologists, having a genome in hand is only the beginning—much more investigation is still needed to characterize how the genome is used to help to produce a functional organism (see the Perspective by Blaxter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af1c9379c54f3982c93a77444265918c
https://doi.org/10.1126/science.1196914

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Comparative analysis of metazoan chromatin organization

Autor: Thea A. Egelhofer, Maxwell W. Libbrecht, Michael M. Hoffman, Ju Han Kim, David M. MacAlpine, William Stafford Noble, Charles B. Epstein, Alex Appert, Q. Brent Chen, Michael J. Pazin, Peter J. Park, Manolis Kellis, Aki Minoda, Sheng'en Shawn Hu, Moritz Herrmann, Chitra V. Kotwaliwale, Jason A. Belsky, Jason D. Lieb, Susan Strome, Sasha A. Langley, Tingting Gu, Sevinc Ercan, Youngsook L. Jung, Kyung-Ah Sohn, Joshua W. K. Ho, Daniel He, Xikun Duan, Gary H. Karpen, Erica Larschan, Noam Shoresh, Isabel J. Latorre, Tao Liu, Bradley E. Bernstein, Bo Qin, Artyom A. Alekseyenko, Ron A.-J. Chen, Nicole C. Riddle, Przemyslaw Stempor, A. Vielle, Jacob M. Garrigues, Andreas Rechtsteiner, Huiling Xue, Tess E. Jeffers, Xiaole Shirley Liu, Burak H. Alver, Sarah K. Bowman, Anshul Kundaje, Stephen C. J. Parker, Peter V. Kharchenko, Soohyun Lee, Richard W. Park, Kohta Ikegami, Elise A. Feingold, Julie Ahringer, Psalm Haseley, Annette Plachetka, P. Kolasinska-Zwierz, Sarah C. R. Elgin, Vincenzo Pirrotta, Abby F. Dernburg, Eric Bishop, Yan Dong, Peter J. Good, Michael Y. Tolstorukov, Francesco Ferrari, Thomas D. Tullius, Xueqiu Lin, Yuri B. Schwartz, Chengyang Wang, Daniel S. Day, Dalal Asker, Andréa C. Dosé, Nischay Kumar, Christina M. Whittle, Robert E. Kingston, Nils Gehlenborg, Mitzi I. Kuroda, Hoang N. Pham

Publikováno v: Nature, vol 512, iss 7515
Nature

Genome function is dynamically regulated in part by chromatin, which consists of the histones, non-histone proteins and RNA molecules that package DNA. Studies in Caenorhabditis elegans and Drosophila melanogaster have contributed substantially to ou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25214de76e78b67a2ecafcb1e36b0481
https://escholarship.org/uc/item/6f66s6x2