Zobrazeno 1 - 10
of 42
pro vyhledávání: '"P. K. Darcy"'
Autor:
L. H. Porter, J. J. Zhu, N. L. Lister, S. G. Harrison, S. Keerthikumar, D. L. Goode, R. Quezada Urban, D. J. Byrne, A. Azad, I. Vela, M. S. Hofman, P. J. Neeson, P. K. Darcy, J. A. Trapani, R. A. Taylor, G. P. Risbridger
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Chimeric antigen receptor (CAR) T cells have transformed the treatment landscape for hematological malignancies. However, CAR T cells are less efficient against solid tumors, largely due to poor infiltration resulting from the immunosuppress
Externí odkaz:
https://doaj.org/article/eb8dadc0a7e045c7b9cf4a1d7631aa08
Autor:
H. Halse, A. J. Colebatch, P. Petrone, M. A. Henderson, J. K. Mills, H. Snow, J. A. Westwood, S. Sandhu, J. M. Raleigh, A. Behren, J. Cebon, P. K. Darcy, M. H. Kershaw, G. A. McArthur, D. E. Gyorki, P. J. Neeson
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract A prospective study explored the heterogeneous nature of metastatic melanoma using Multiplex immunohistochemistry (IHC) and flow cytometry (FACS). Multiplex IHC data quantitated immune subset number present intra-tumoral (IT) vs the tumor st
Externí odkaz:
https://doaj.org/article/1046ef03187a4802bf52b2ca77c01675
Autor:
Kirsten L. Todd, Junyun Lai, Kevin Sek, Yu-Kuan Huang, Dane M. Newman, Emily B. Derrick, Hui-Fern Koay, Dat Nguyen, Thang X. Hoang, Emma V. Petley, Cheok Weng Chan, Isabelle Munoz, Imran G. House, Joel N. Lee, Joelle S. Kim, Jasmine Li, Junming Tong, Maria N. de Menezes, Christina M. Scheffler, Kah Min Yap, Amanda X. Y. Chen, Phoebe A. Dunbar, Brandon Haugen, Ian A. Parish, Ricky W. Johnstone, Phillip K. Darcy, Paul A. Beavis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract There is significant clinical interest in targeting adenosine-mediated immunosuppression, with several small molecule inhibitors having been developed for targeting the A2AR receptor. Understanding of the mechanism by which A2AR is regulated
Externí odkaz:
https://doaj.org/article/b9c76314c12142099494e8759d06a025
Autor:
Imran G. House, Emily B. Derrick, Kevin Sek, Amanda X.Y. Chen, Jasmine Li, Junyun Lai, Kirsten L. Todd, Isabelle Munoz, Jessica Michie, Cheok Weng Chan, Yu-Kuan Huang, Jack D. Chan, Emma V. Petley, Junming Tong, DatMinh Nguyen, Sven Engel, Peter Savas, Simon J. Hogg, Stephin J. Vervoort, Conor J. Kearney, Marian L. Burr, Enid Y.N. Lam, Omer Gilan, Sammy Bedoui, Ricky W. Johnstone, Mark A. Dawson, Sherene Loi, Phillip K. Darcy, Paul A. Beavis
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113793- (2024)
Externí odkaz:
https://doaj.org/article/3bc9e9ff1e6348e1add4deb56de520ff
Autor:
Kelden Richardson, Simon P. Keam, Joe Jiang Zhu, Deborah Meyran, Criselle D’Souza, Sean Macdonald, Kerry Campbell, Michael Robbins, Natalie A. Bezman, Kirsten Todd, Hang Quach, David S. Ritchie, Simon J. Harrison, H. Miles Prince, Joseph A. Trapani, Misty R. Jenkins, Paul A. Beavis, Phillip K. Darcy, Paul J. Neeson
Publikováno v:
Haematologica, Vol 108, Iss 1 (2022)
Patients with refractory relapsed multiple myeloma respond to combination treatment with elotuzumab and lenalidomide. The mechanisms underlying this observation are not fully understood. Furthermore, biomarkers predictive of response have not been id
Externí odkaz:
https://doaj.org/article/330bde42af204d128415d365b42720c4
Autor:
Criselle D’Souza, Simon P. Keam, Han Xian Aw Yeang, Michael Neeson, Kelden Richardson, Andy K. Hsu, Rachael Canfield, Natalie Bezman, Michael Robbins, Hang Quach, David S. Ritchie, Simon J. Harrison, Joseph A. Trapani, H. Miles Prince, Paul A. Beavis, Phillip K. Darcy, Paul J. Neeson
Publikováno v:
Haematologica, Vol 106, Iss 9 (2021)
Externí odkaz:
https://doaj.org/article/ffb9fcdcc42040a99e9894fa282c2f05
Autor:
Jonas RM Van Audenaerde, Elly Marcq, Bianca vonScheidt, Ashleigh S Davey, Amanda J Oliver, Jorrit De Waele, Delphine Quatannens, Jinthe Van Loenhout, Patrick Pauwels, Geert Roeyen, Filip Lardon, Clare Y Slaney, Marc Peeters, Michael H Kershaw, Phillip K Darcy, Evelien LJM Smits
Publikováno v:
Clinical & Translational Immunology, Vol 9, Iss 8, Pp n/a-n/a (2020)
Abstract Objectives With the poorest 5‐year survival of all cancers, improving treatment for pancreatic cancer is one of the biggest challenges in cancer research. We sought to explore the potential of combining both priming and activation of the i
Externí odkaz:
https://doaj.org/article/b9d446da1e9b4c0f9e0a3b2ed6c08998
Autor:
Simon J. Hogg, Stephin J. Vervoort, Sumit Deswal, Christopher J. Ott, Jason Li, Leonie A. Cluse, Paul A. Beavis, Phillip K. Darcy, Benjamin P. Martin, Andrew Spencer, Anna K. Traunbauer, Irina Sadovnik, Karin Bauer, Peter Valent, James E. Bradner, Johannes Zuber, Jake Shortt, Ricky W. Johnstone
Publikováno v:
Cell Reports, Vol 18, Iss 9, Pp 2162-2174 (2017)
Summary: BET inhibitors (BETi) target bromodomain-containing proteins and are currently being evaluated as anti-cancer agents. We find that maximal therapeutic effects of BETi in a Myc-driven B cell lymphoma model required an intact host immune syste
Externí odkaz:
https://doaj.org/article/7831449cccec4074b10637bac98536e0
Autor:
Jamie A. Lopez, Tahereh Noori, Adrian Minson, Lu Li Jovanoska, Kevin Thia, Michael S. Hildebrand, Hedieh Akhlaghi, Phillip K. Darcy, Michael H. Kershaw, Natasha J. Brown, Andrew Grigg, Joseph A. Trapani, Ilia Voskoboinik
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The ability of cytotoxic lymphocytes (CL) to eliminate virus-infected or cancerous target cells through the granule exocytosis death pathway is critical to immune homeostasis. Congenital loss of CL function due to bi-allelic mutations in PRF1, UNC13D
Externí odkaz:
https://doaj.org/article/7b7c9fbb0a424695a61c0ec7c5f47808
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