Zobrazeno 1 - 10 of 38 pro vyhledávání: '"P. K. Buxton"'
1
Akademický článek
EAT-18 is an essential auxiliary protein interacting with the non-alpha nAChR subunit EAT-2 to form a functional receptor.
Autor: Shivani Choudhary, Samuel K Buxton, Sreekanth Puttachary, Saurabh Verma, Gunnar R Mair, Ciaran J McCoy, Barbara J Reaves, Adrian J Wolstenholme, Richard J Martin, Alan P Robertson
Publikováno v: PLoS Pathogens, Vol 16, Iss 4, p e1008396 (2020)
Nematode parasites infect approximately 1.5 billion people globally and are a significant public health concern. There is an accepted need for new, more effective anthelmintic drugs. Nicotinic acetylcholine receptors on parasite nerve and somatic mus
Externí odkaz: https://doaj.org/article/aaa14d3e9cdb433296675d4c9b44bba7
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2
Akademický článek
Curiouser and Curiouser: The Macrocyclic Lactone, Abamectin, Is also a Potent Inhibitor of Pyrantel/Tribendimidine Nicotinic Acetylcholine Receptors of Gastro-Intestinal Worms.
Autor: Melanie Abongwa, Samuel K Buxton, Alan P Robertson, Richard J Martin
Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0146854 (2016)
Nematode parasites may be controlled with drugs, but their regular application has given rise to concerns about the development of resistance. Drug combinations may be more effective than single drugs and delay the onset of resistance. A combination
Externí odkaz: https://doaj.org/article/1f3cc213bfd84f43b3fb95f93e244db7
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3
Akademický článek
Tribendimidine: mode of action and nAChR subtype selectivity in Ascaris and Oesophagostomum.
Autor: Alan P Robertson, Sreekanth Puttachary, Samuel K Buxton, Richard J Martin
Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 2, p e0003495 (2015)
The cholinergic class of anthelmintic drugs is used for the control of parasitic nematodes. One of this class of drugs, tribendimidine (a symmetrical diamidine derivative, of amidantel), was developed in China for use in humans in the mid-1980s. It h
Externí odkaz: https://doaj.org/article/c8388613a71b455b8f3217e10f8bb7c6
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4
Akademický článek
Investigation of acetylcholine receptor diversity in a nematode parasite leads to characterization of tribendimidine- and derquantel-sensitive nAChRs.
Autor: Samuel K Buxton, Claude L Charvet, Cedric Neveu, Jacques Cabaret, Jacques Cortet, Nicolas Peineau, Melanie Abongwa, Elise Courtot, Alan P Robertson, Richard J Martin
Publikováno v: PLoS Pathogens, Vol 10, Iss 1, p e1003870 (2014)
Nicotinic acetylcholine receptors (nAChRs) of parasitic nematodes are required for body movement and are targets of important "classical" anthelmintics like levamisole and pyrantel, as well as "novel" anthelmintics like tribendimidine and derquantel.
Externí odkaz: https://doaj.org/article/be0879b4a8b04c91a8eaccf07faabcc7
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5
Akademický článek
Diethylcarbamazine increases activation of voltage-activated potassium (SLO-1) currents in Ascaris suum and potentiates effects of emodepside.
Autor: Samuel K Buxton, Alan P Robertson, Richard J Martin
Publikováno v: PLoS Neglected Tropical Diseases, Vol 8, Iss 11, p e3276 (2014)
Diethylcarbamazine is a drug that is used for the treatment of filariasis in humans and animals; it also has effects on intestinal nematodes, but its mechanism of action remains unclear. Emodepside is a resistance-busting anthelmintic approved for tr
Externí odkaz: https://doaj.org/article/c14b35ddd3e84b7fa382b95227c2e6ef
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6
The prevalence of dermatophyte infection in well-controlled diabetics and the response to Trichophyton antigen
Autor: P K, Buxton, L J, Milne, R J, Prescott, M C, Proudfoot, F M, Stuart
Publikováno v: The British journal of dermatology. 134(5)
The prevalence of dermatophyte infection was assessed in 100 patients with well-controlled insulin-dependent diabetes, and in a control group of 100 non-diabetics matched for age, sex, occupation and sporting activity. Immediate and delayed responses
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bec040f04c87157402af323ae35e2a8a
https://pubmed.ncbi.nlm.nih.gov/8736332
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7
Contact hypersensitivity in patients with chronic otitis externa
Autor: D. G. Keay, I. M. Smith, P. K. Buxton
Publikováno v: Clinical otolaryngology and allied sciences. 15(2)
Thirty-seven patients with chronic otitis externa were investigated for contact hypersensitivity to 49 agents using standardized patch testing. Positive reactions were found in 22 (58%) patients. This incidence is higher than the 40% found in the onl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff451c931189709c26d21ded28701ac
https://pubmed.ncbi.nlm.nih.gov/2350893
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9
Para-aminobenzoate in lichen sclerosus et atrophicus
Autor: P. K. Buxton, G. C. Priestley
Publikováno v: Journal of Dermatological Treatment. 1:255-256
A double-blind placebo-controlled trial of oral paraaminobenzoate (Potaba) was carried out with 25 patients suffering from lichen sclerosus et atrophicus. Of the 21 patients who completed the two month trial, six showed some improvement on Potaba aga
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79fe78709d11f9178b12305b261f5575
https://doi.org/10.3109/09546639009086746
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