Zobrazeno 1 - 10
of 13
pro vyhledávání: '"P. Julian Dyson"'
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Natural killer (NK) cell responses depend on the balance of signals from inhibitory and activating receptors. However, how the integration of antagonistic signals occurs upon NK cell–target cell interaction is not fully understood. Here we provide
Externí odkaz:
https://doaj.org/article/94db0b8324664817a1f5cf288ba0a58a
Autor:
Jean-Pierre Abastado, François A. Lemonnier, Francesco Colucci, Lisa A. Cotterill, Margarita Salcedo, Philippe Kourilsky, P. Julian Dyson, James P. Di Santo, Hans-Gustaf Ljunggren
Publikováno v:
European Journal of Immunology. 30:1094-1101
NK cells acquire the ability to recognize MHC class I molecules during development. Studies with Qa-1(b) tetramers (Qa-1 tetramers) showed that nearly all NK1.1(+) cells from newborn C57BL/6 mice express Qa-1-binding receptors. Cytotoxic activity of
Autor:
Jennifer A. Toomey, Margarita Salcedo, Lisa A. Cotterill, Margaret M. Millrain, Zosia Chrzanowska-Lightowlers, John Lawry, Karen Fraser, Frances Gays, John H. Robinson, Sunil Shrestha, P. Julian Dyson, Colin G. Brooks
Publikováno v:
The Journal of Immunology. 163:3176-3184
Fetal mouse NK cells are grossly deficient in the expression of Ly49 molecules yet show a limited ability to distinguish between wild-type and MHC class I-deficient target cells. In this paper we report that during their development in vitro from imm
Autor:
P. Julian Dyson, James I. Elliott
Publikováno v:
European Journal of Immunology. 29:1456-1466
Though C57BL/10 mice express the mouse mammary tumor virus superantigens (sag) encoded by Mtv-8 and Mtv-9, it has been thought that these sag do not bind to the MHC class II molecule H2-Ab and consequently do not affect the T cell repertoire. However
Autor:
Daniel M. Altmann, P. Julian Dyson, Tomasz Zal, Andrew L. Mellor, Daniel C. Douek, Kevin T. T. Corley
Publikováno v:
International Immunology. 8:1413-1420
The site of negative selection in the thymus has been inferred from a range of different experiments. Analysis of thymic deletion of V beta 5+, V beta 11+ or V beta 17a+ cells in H-2E transgenic mice led to the theory that negative selection occurs p
Publikováno v:
European Journal of Immunology. 25:2813-2817
Allelic exclusion of T cell receptor (TCR) genes is incomplete: a significant percentage (10-30%) of normal human and mouse peripheral T cells express two surface TCR alpha chains, and a small percentage of peripheral human T cells have been reported
Publikováno v:
Immunogenetics. 34:227-230
A gene encoding the endogenous superantigen Mlsc, which deletes Tcrb-V3+ T cells in the NOD inbred mouse strain, was found to co-segregate with Mtv-3 on chromosome 11. This identifies a fourth gene encoding a deletion ligand for Tcrb-V3+ T cells and
Autor:
P. Julian Dyson, Scott J. Roberts, Bruno Silva-Santos, Adrian Smith, Adrian Hayday, Monica Escorcio-Correia, Tobias Silberzahn, Martin Woodward, Daniel J. Pennington
Publikováno v:
Nature. 444(7122)
In cellular immunology the critical balance between effector and regulatory mechanisms is highlighted by serious immunopathologies attributable to mutations in Foxp3, a transcription factor required for a major subset of regulatory T (Tr) cells. Thus
Autor:
James I. Elliott, P. Julian Dyson, Andrew M. Knight, Daniel M. Altmann, Petter J. Robinson, Elizabeth M. Simpson
Publikováno v:
Immunological reviews. 131
Publikováno v:
Differentiation; research in biological diversity. 42(1)
Mouse c-myb has ben implicated in the regulation of differentiation and proliferation of haematopoietic cells. Analysis of the chromatin structure of the promoter region of c-myb in embryonal carcinoma (EC) cells and embryonal stem (ES) cells reveals