Zobrazeno 1 - 10 of 581 pro vyhledávání: '"P. Jeffrey Conn"'
1
Akademický článek
Modeling Intrahippocampal Effects of Anterior Hippocampal Hyperactivity Relevant to Schizophrenia Using Chemogenetic Excitation of Long Axis–Projecting Mossy Cells in the Mouse Dentate Gyrus
Autor: James P. Bauer, Sarah L. Rader, Max E. Joffe, Wooseok Kwon, Juliana Quay, Leann Seanez, Chengwen Zhou, P. Jeffrey Conn, Alan S. Lewis
Publikováno v: Biological Psychiatry Global Open Science, Vol 1, Iss 2, Pp 101-111 (2021)
Background: The anterior hippocampus of individuals with early psychosis or schizophrenia is hyperactive, as is the ventral hippocampus in many rodent models for schizophrenia risk. Mossy cells (MCs) of the ventral dentate gyrus (DG) densely project
Externí odkaz: https://doaj.org/article/8a9ca9a844ee44ec836d967e7a3b4137
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2
Akademický článek
mGlu1 potentiation enhances prelimbic somatostatin interneuron activity to rescue schizophrenia-like physiological and cognitive deficits
Autor: James Maksymetz, Nellie E. Byun, Deborah J. Luessen, Brianna Li, Robert L. Barry, John C. Gore, Colleen M. Niswender, Craig W. Lindsley, Max E. Joffe, P. Jeffrey Conn
Publikováno v: Cell Reports, Vol 37, Iss 5, Pp 109950- (2021)
Summary: Evidence for prefrontal cortical (PFC) GABAergic dysfunction is one of the most consistent findings in schizophrenia and may contribute to cognitive deficits. Recent studies suggest that the mGlu1 subtype of metabotropic glutamate receptor r
Externí odkaz: https://doaj.org/article/a075ccbe92734d68bafa119211f41b75
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4
Akademický článek
A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes
Autor: Nicole M. Fisher, Aqeela AlHashim, Aditi B. Buch, Hana Badivuku, Manar M. Samman, Kelly M. Weiss, Gabriela I. Cestero, Mark D. Does, Jerri M. Rook, Craig W. Lindsley, P. Jeffrey Conn, Rocco G. Gogliotti, Colleen M. Niswender
Publikováno v: JCI Insight, Vol 6, Iss 4 (2021)
The metabotropic glutamate receptor 7 (mGlu7) is a G protein–coupled receptor that has been recently linked to neurodevelopmental disorders. This association is supported by the identification of GRM7 variants in patients with autism spectrum disor
Externí odkaz: https://doaj.org/article/a777c073552d4febb04f18fa5a845f7b
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6
Akademický článek
Targeting metabotropic glutamate receptors for novel treatments of schizophrenia
Autor: James Maksymetz, Sean P. Moran, P. Jeffrey Conn
Publikováno v: Molecular Brain, Vol 10, Iss 1, Pp 1-19 (2017)
Abstract Support for the N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis of schizophrenia has led to increasing focus on restoring proper glutamatergic signaling as an approach for treatment of this devastating disease. The ability of m
Externí odkaz: https://doaj.org/article/4a1b8eaa1f5846ef86557a168d221c08
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7
Allosteric Modulators of Metabotropic Glutamate Receptors as Novel Therapeutics for Neuropsychiatric Disease
Autor: Deborah J, Luessen, P Jeffrey, Conn
Publikováno v: Pharmacological Reviews. 74:630-661
Metabotropic glutamate (mGlu) receptors, a family of G-protein-coupled receptors, have been identified as novel therapeutic targets based on extensive research supporting their diverse contributions to cell signaling and physiology throughout the ner
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0616a4eb964885b70c77db0e3dd86bc
https://doi.org/10.1124/pharmrev.121.000540
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