Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties

Autor: Simon J. Allison, Jaroslaw Bryk, Christopher J. Clemett, Robert A. Faulkner, Michael Ginger, Hollie B. S. Griffiths, Jane Harmer, P. Jane Owen-Lynch, Emma Pinder, Heiko Wurdak, Roger M. Phillips, Craig R. Rice

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Artificial self-assembling systems such as anion receptors or ‘binders’ are largely unexplored for therapeutic applications. Here, the authors report self-assembling trimetallic cryptands containing copper, zinc or manganese that encapsulate a ra

Externí odkaz: https://doaj.org/article/5894d27a002d445592149ac898aef1be

COHERENCE BETWEEN FLUCTUATIONS IN BLOOD FLOW AND OXYGEN SATURATION

Autor: ALAN BERNJAK, ANETA STEFANOVSKA, PETER V. E. McCLINTOCK, P. JANE OWEN-LYNCH, PETER B. M. CLARKSON

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c212b70cfddcfc91e154b03fa89dbb23
https://doi.org/10.1142/9789811252143_0033

Ruthenium-Containing Linear Helicates and Mesocates with Tuneable p53-Selective Cytotoxicity in Colorectal Cancer Cells

Autor: Robert A. Faulkner, Craig R. Rice, Owen J. Harper, Roger M. Phillips, David J. Cooke, Samantha L. Shepherd, Simon J. Allison, Richard T. Wheelhouse, Hollie B. S. Griffiths, Omar Khadeer Hussain, Paul I. P. Elliott, Francesca S. Davidson, P. Jane Owen-Lynch

Publikováno v: Allison, S J, Cooke, D, Davidson, F S, Elliott, P I P, Faulkner, R A, Griffiths, H B S, Harper, O, Hussain, O, Owen-Lynch, P J, Phillips, R M, Rice, C R, Shepherd, S L & Wheelhouse, R T 2018, ' Ruthenium-Containing Linear Helicates and Mesocates with Tuneable p53-Selective Cytotoxicity in Colorectal Cancer Cells ', Angewandte Chemie-International Edition, vol. 57, no. 31, pp. 9799-9804 . https://doi.org/10.1002/anie.201805510

The ligands L1 and L2 both form separable dinuclear double-stranded helicate and mesocate complexes with RuII . In contrast to clinically approved platinates, the helicate isomer of [Ru2 (L1 )2 ]4+ was preferentially cytotoxic to isogenic cells (HCT1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e9edece6e9c1a660ee5a318687a30e
https://pubmed.ncbi.nlm.nih.gov/29863754

Deficient cortical development in the hydrocephalic Texas (H-Tx) rat: a role for CSF

Autor: Carys M. Bannister, Mohsen Pourghasem, P. Jane Owen-Lynch, Jaleel A. Miyan, Clare E. Draper, Farhad Mashayekhi

Publikováno v: Brain. 125:1859-1874

The objectives of this study were to demonstrate the presence and nature of abnormal cortical development in a rat model of hydrocephalus, the hydrocephalic Texas (H-Tx) rat, and to test the hypothesis that the obstruction of CSF flow in affected ani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216ea02904efcc1e3547c1da115ebcbc
https://doi.org/10.1093/brain/awf182

Coherence between fluctuations in blood flow and oxygen saturation

Autor: Peter V. E. McClintock, Alan Bernjak, Aneta Stefanovska, P. Jane Owen-Lynch, Peter Clarkson

We have determined the wavelet phase coherence between simultaneously recorded microvascular blood flow and oxygen saturation signals from 88 healthy subjects, thus enabling us to study their common fluctuations. Measurements were taken for 30 min fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11fa58a4dbfbee90b6bf5b358104472
https://doi.org/10.1142/S0219477512400135