Zobrazeno 1 - 10
of 73
pro vyhledávání: '"P. J. de Jonge"'
Autor:
Janeska J. de Jonge, Andreas Graw, Vasileios Kargas, Christopher Batters, Antonino F. Montanarella, Tom O’Loughlin, Chloe Johnson, Susan D. Arden, Alan J. Warren, Michael A. Geeves, John Kendrick-Jones, Nathan R. Zaccai, Markus Kröss, Claudia Veigel, Folma Buss
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Myosin motors perform many fundamental functions in eukaryotic cells by providing force generation, transport or tethering capacity. Motor activity control within the cell involves on/off switches, however, few examples are known of how myos
Externí odkaz:
https://doaj.org/article/7154c67ddb744e59a37c38b04052c87d
Autor:
Tamara W. van Hal, Juul M. P. A. van den Reek, Mark H. Wenink, Marisol E. Otero, Paul M. Ossenkoppele, Marcellus D. Njoo, Annet Oostveen, Bas Peters, Milan Tjioe, Else N. Kop, John E. M. Körver, Sharon R. P. Dodemont, Marloes M. Kleinpenning, Maartje A. M. Berends, Wendelien R. Veldkamp, Martijn B. A. van Doorn, Johannes M. Mommers, Robert-Jan Lindhout, Astrid L. A. Kuijpers, Paula P. van Lümig, C. (Els) J. de Jonge, Ron A. Tupker, Judith Hendricksen, Romy R. Keijsers, Frank H. J. van den Hoogen, Johanna E. Vriezekolk, Elke M. G. J. de Jong
Publikováno v:
Journal of Dermatological Treatment, Vol 35, Iss 1 (2024)
Background: Little is known about the extent of impairments in work and activities of daily life (ADL) in patients with psoriasis, and the influence of contextual factors such as disease-related characteristics and treatment. Therefore, this study ai
Externí odkaz:
https://doaj.org/article/a0ecbd2dbd2848a58e15cb47119ba98d
Autor:
Hung-Jen Chen, Daniel C. Sévin, Guillermo R. Griffith, Johanna Vappiani, Lee M. Booty, Cindy P.A.A. van Roomen, Johan Kuiper, Jeroen den Dunnen, Wouter J. de Jonge, Rab K. Prinjha, Palwinder K. Mander, Paola Grandi, Beata S. Wyspianska, Menno P.J. de Winther
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114741- (2024)
Summary: Macrophages exhibit diverse phenotypes and respond flexibly to environmental cues through metabolic remodeling. In this study, we present a comprehensive multi-omics dataset integrating intra- and extracellular metabolomes with transcriptomi
Externí odkaz:
https://doaj.org/article/ae89bd3f7a5c4e6f9f0d1640e1046c34
Autor:
Francesca P. Giugliano, Marit Navis, Sarah Ouahoud, Tânia Martins Garcia, Irini A.M. Kreulen, Evelina Ferrantelli, Sander Meisner, Jacqueline L.M. Vermeulen, Manon van Roest, Jean-Noël Billaud, Jan Koster, Yousif Dawood, Bernadette S. de Bakker, Daisy I. Picavet-Havik, Irene M. Schimmel, Nicole N. van der Wel, Pim J. Koelink, Manon E. Wildenberg, Joep P.M. Derikx, Wouter J. de Jonge, Ingrid B. Renes, Ruurd M. van Elburg, Vanesa Muncan
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109909- (2024)
Summary: Small intestine (SI) maturation during early life is pivotal in preventing the onset of gut diseases. In this study we interrogated the milestones of SI development by gene expression profiling and ingenuity pathway analyses. We identified a
Externí odkaz:
https://doaj.org/article/471bf6ea022848e0a4e16b1d7e10442e
Autor:
Emma A. R. Zuiderveen, Koen J. J. Kuipers, Carla Caldeira, Steef V. Hanssen, Mitchell K. van der Hulst, Melinda M. J. de Jonge, Anestis Vlysidis, Rosalie van Zelm, Serenella Sala, Mark A. J. Huijbregts
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-7 (2023)
Abstract The current debate on the sustainability of bio-based products questions the environmental benefits of replacing fossil- by bio-resources. Here, we analyze the environmental trade-offs of 98 emerging bio-based materials compared to their fos
Externí odkaz:
https://doaj.org/article/0430283d546b4288bbd291c0a0fdefe6
Autor:
Anne S. ten Hove, Shilpashree Mallesh, Konstantina Zafeiropoulou, Janna W. M. de Kleer, Patricia H. P. van Hamersveld, Olaf Welting, Theodorus B. M. Hakvoort, Sven Wehner, Jurgen Seppen, Wouter J. de Jonge
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Innervation of the intestinal mucosa by the sympathetic nervous system is well described but the effects of adrenergic receptor stimulation on the intestinal epithelium remain equivocal. We therefore investigated the effect of sympathetic ne
Externí odkaz:
https://doaj.org/article/e4a1811c0b074b8a8f1858800a93a3fa
Autor:
Mohammed Ghiboub, Matthew Bell, Dovile Sinkeviciute, Rab K. Prinjha, Menno P. J. de Winther, Nicola R. Harker, David F. Tough, Wouter J. de Jonge
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 5, Pp 4228-4245 (2023)
SP140 is an epigenetic reader protein expressed predominantly in immune cells. GWAS studies have shown an association between SP140 single nucleotide polymorphisms (SNPs) and diverse autoimmune and inflammatory diseases, suggesting a possible pathoge
Externí odkaz:
https://doaj.org/article/3c050099aea741a3bd355412024aa66a
Autor:
Ishtu Hageman, Femke Mol, Sadaf Atiqi, Vincent Joustra, Hilal Sengul, Peter Henneman, Ingrid Visman, Theodorus Hakvoort, Mike Nurmohamed, Gertjan Wolbink, Evgeni Levin, Andrew Y.F. Li Yim, Geert D’Haens, Wouter J. de Jonge
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Background and aimsRheumatoid arthritis (RA) patients are currently treated with biological agents mostly aimed at cytokine blockade, such as tumor necrosis factor-alpha (TNFα). Currently, there are no biomarkers to predict therapy response to these
Externí odkaz:
https://doaj.org/article/499f4a55150d46dd8f718dd216142698
Autor:
Vincent Joustra, Andrew Y.F. Li Yim, Ishtu Hageman, Evgeni Levin, Alex Adams, Jack Satsangi, Wouter J. de Jonge, Peter Henneman, Geert D’Haens
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 4, Pp 869-885 (2023)
Background & Aims: There is great current interest in the potential application of DNA methylation alterations in peripheral blood leukocytes (PBLs) as biomarkers of susceptibility, progression, and treatment response in inflammatory bowel disease (I
Externí odkaz:
https://doaj.org/article/f4da3dfe0cbe411593eca99d4377a2f6
Autor:
Christopher J. De Jonge, Steven A. Gellatly, Mónica H. Vazquez-Levin, Christopher L.R. Barratt, Satu Rautakallio-Hokkanen
Publikováno v:
The World Journal of Men's Health, Vol 41, Iss 1, Pp 204-214 (2023)
Purpose: In general, men are less likely to seek health care than women. Infertility is a global disease that afflicts approximately 15% of reproductive age couples and the male contributes to 40% of the diagnosable cause. Remarkably, no large or m
Externí odkaz:
https://doaj.org/article/ba373fc0f9cf4eababdb6f760a184ce9