Zobrazeno 1 - 10
of 44
pro vyhledávání: '"P. J. Turchi"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The ATR kinase responds to elevated levels of single-stranded DNA (ssDNA) to activate the G2/M checkpoint, regulate origin utilization, preserve fork stability, and allow DNA repair to ensure genome integrity. The intrinsic replication stres
Externí odkaz:
https://doaj.org/article/8a410c8e2c3944e69d6312c7d91f5b39
Autor:
Joy Garrett, Erin Metzger, Mark W. Dewhirst, Karen E. Pollok, John J. Turchi, Isabelle C. Le Poole, Kira Couch, Logan Lew, Anthony Sinn, Jeffrey M. Zaleski, Joseph R. Dynlacht
Publikováno v:
International Journal of Hyperthermia, Vol 39, Iss 1, Pp 405-413 (2022)
Background Enediynes are anti-cancer agents that are highly cytotoxic due to their propensity for low thermal activation of radical generation. The diradical intermediate produced from Bergman cyclization of the enediyne moiety may induce DNA damage
Externí odkaz:
https://doaj.org/article/7245f922c324473d88674548fe76d2e9
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/d148412c778249528a51a49c7bf23f14
Autor:
Jeremy M. Kelm, Amirreza Samarbakhsh, Athira Pillai, Pamela S. VanderVere-Carozza, Hariprasad Aruri, Deepti S. Pandey, Katherine S. Pawelczak, John J. Turchi, Navnath S. Gavande
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The vast majority of cancer patients receive DNA-damaging drugs or ionizing radiation (IR) during their course of treatment, yet the efficacy of these therapies is tempered by DNA repair and DNA damage response (DDR) pathways. Aberrations in DNA repa
Externí odkaz:
https://doaj.org/article/74a34493f8cf45abaafceb2411d093e9
Autor:
Pamela S. VanderVere-Carozza, Navnath S. Gavande, Shadia I. Jalal, Karen E. Pollok, Elmira Ekinci, Joshua Heyza, Steve M. Patrick, Andi Masters, John J. Turchi, Katherine S. Pawelczak
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Replication protein A (RPA) plays essential roles in DNA replication, repair, recombination, and the DNA damage response (DDR). Retrospective analysis of lung cancer patient data demonstrates high RPA expression as a negative prognostic biomarker for
Externí odkaz:
https://doaj.org/article/1d4434aabcf24c4eb69ee21c9ff5887f
Autor:
Bakhtiyor Yakubov, Bhadrani Chelladurai, Jordan Schmitt, Robert Emerson, John J. Turchi, Daniela Matei
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 6, Pp 609-619 (2013)
Tissue transglutaminase (TG2) is a multifunctional protein that binds to fibronectin and exerts protein transamidating activity in the presence of Ca2+. We previously reported that TG2 is upregulated in ovarian tumors and enhances intraperitoneal (i.
Externí odkaz:
https://doaj.org/article/8064ecb2fcce4ceb85f7b147298cd55e
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127321 (2015)
DNA double strand breaks (DSBs) can be generated by endogenous cellular processes or exogenous agents in mammalian cells. These breaks are highly variable with respect to DNA sequence and structure and all are recognized in some context by the DNA-de
Externí odkaz:
https://doaj.org/article/c935a59e93134687aa1268a839350109
Autor:
Victor J. Anciano Granadillo, Jennifer N. Earley, Sarah C. Shuck, Millie M. Georgiadis, Richard W. Fitch, John J. Turchi
Publikováno v:
Journal of Nucleic Acids, Vol 2010 (2010)
Replication protein A (RPA) is the main eukaryotic single-strand (ss) DNA-binding protein involved in DNA replication and repair. We have identified and developed two classes of small molecule inhibitors (SMIs) that show in vitro inhibition of the RP
Externí odkaz:
https://doaj.org/article/105fba2e831342b5a65de6130732dac8
Autor:
D. W. Price, D. Dietz, J.D. Graham, E. A. Lopez, W. L. Baker, S. K. Coffey, R.E. Peterkin, J. S. Buff, J.H. Degnan, C.J. Clouse, N. F. Roderick, M. L. Alme, C. R. Sovinec, D. J. Hall, J.L. Holmes, P. J. Turchi, M. H. Frese, J.D. Beason, C. N. Boyer, S. W. Seiler
Publikováno v:
Fusion Technology. 27:115-123
Electromagnetic implosions of shaped cylindrical aluminum liners that remain at solid density are discussed. The approximate liner parameters have an initial radius of 3 to 4 cm, are 4 cm in height, and are nearly 0.1 cm thick. The liners are driven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::272bf88de19203a989b575ba77b52ca5
https://doi.org/10.13182/fst95-a30368
https://doi.org/10.13182/fst95-a30368
Autor:
D. W. Price, J.D. Graham, D. Dietz, D.B. Dunlap, G.P. Baca, P. J. Turchi, R.A. Lewis, S.E. Englert, J.H. Degnan, F.M. Lehr, T.J. Englert, N. F. Roderick, G.A. Smith, D.E. Bell, C.A. Outten, A.L. Chesley, Uri Shumlak, Thomas W. Hussey, R.E. Peterkin, J.J. Havranek, C.D. Holmberg, J.D. Beason, S. K. Coffey, D.G. Gale, E.L. Ruden
Publikováno v:
Physical Review Letters. 74:98-101
We have magnetically driven a tapered-thickness spherical aluminum shell implosion with a 12.5 MA axial discharge. The initially 4 cm radius, 0.1 to 0.2 cm thick, [plus minus]45[sup [degree]] latitude shell was imploded along conical electrodes. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5cd0af8376e08718cbef796f78c4f1
https://doi.org/10.1103/physrevlett.74.98
https://doi.org/10.1103/physrevlett.74.98