Zobrazeno 1 - 10
of 52
pro vyhledávání: '"P. J. Tofilon"'
Autor:
Charlotte Degorre, Steven Lohard, Christina N. Bobrek, Komal N. Rawal, Skyler Kuhn, Philip J. Tofilon
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract PRMT5 is a widely expressed arginine methyltransferase that regulates processes involved in tumor cell proliferation and survival. In the study described here, we investigated whether PRMT5 provides a target for tumor radiosensitization. Kno
Externí odkaz:
https://doaj.org/article/1277a2b62112434899d4c69804c491f9
Autor:
Hong Shik Yun, Tamalee R. Kramp, Kamalakannan Palanichamy, Philip J. Tofilon, Kevin Camphausen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Radiotherapy is the standard treatment for glioblastoma (GBM), but the overall survival rate for radiotherapy treated GBM patients is poor. The use of adjuvant and concomitant temozolomide (TMZ) improves the outcome; however, the effectivene
Externí odkaz:
https://doaj.org/article/a2cb9017ba34447e85204e2424d1bc93
Autor:
Charlotte Degorre, Ian C. Sutton, Stacey L. Lehman, Uma T. Shankavaram, Kevin Camphausen, Philip J. Tofilon
Publikováno v:
Cancer Cell International, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background The invasive nature of GBM combined with the diversity of brain microenvironments creates the potential for a topographic heterogeneity in GBM radioresponse. Investigating the mechanisms responsible for a microenvironment-induced
Externí odkaz:
https://doaj.org/article/acc01da916514c0a8e8f39bc81e249be
Autor:
Stacey L. Lehman, Kayla R. Schwartz, Shrankhla Maheshwari, Kevin Camphausen, Philip J. Tofilon
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Increased ribosome biogenesis is a distinguishing feature of cancer cells, and small molecule inhibitors of ribosome biogenesis are currently in clinical trials as single agent therapy. It has been previously shown that inhibiting ribosome b
Externí odkaz:
https://doaj.org/article/963dcbc4505c4f46bc7e5e3ab7dd2d8c
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10664 (2021)
Towards improving the efficacy of radiotherapy, one approach is to target the molecules and processes mediating cellular radioresponse. Along these lines, translational control of gene expression has been established as a fundamental component of cel
Externí odkaz:
https://doaj.org/article/a3b224df23f34d1ab0cb04e40d08cffa
Publikováno v:
Cancers, Vol 12, Iss 11, p 3260 (2020)
Radiation therapy is a mainstay in the standard of care for glioblastoma (GBM), thus inhibiting the DNA damage response (DDR) is a major strategy to improve radiation response and therapeutic outcomes. Small interfering RNA (siRNA) therapy holds imme
Externí odkaz:
https://doaj.org/article/bdb677e06d294f3684206e2e134a19af
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 2, Pp 150-158 (2012)
Brain tumor xenografts initiated from glioblastoma (GBM) CD133+ tumor stem-like cells (TSCs) are composed of TSC and non-TSC subpopulations, simulating the phenotypic heterogeneity of GBMs in situ. Given that the discrepancies between the radiosensit
Externí odkaz:
https://doaj.org/article/0f54d7ffa3094c72b015edfc9ba63d10
Autor:
A V, Krauze, Mackey, Megan, Cooley-Zgela, Theresa, Mathen, Peter, J H, Shih, P J, Tofilon, L, Rowe, M, Gilbert, K, Camphausen
Publikováno v:
Cancer Stud Ther
PURPOSE/OBJECTIVE(S): Valproic Acid (VPA) is an antiepileptic agent with HDACi (histone deacetylase inhibitor) activity shown to radiosensitize glioblastoma (GBM) cells. We evaluated the addition of VPA to standard radiation therapy (RT) and temozolo
Autor:
Soumen Kahali, Bhaswati Sarcar, Bin Fang, Eli S. Williams, John M. Koomen, Philip J. Tofilon, Prakash Chinnaiyan
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 1, Pp 80-86 (2010)
Histone deacetylase (HDAC) inhibitors represent an emerging class of anticancer agents progressing through clinical trials. Although their primary target is thought to involve acetylation of core histones, several nonhistone substrates have been iden
Externí odkaz:
https://doaj.org/article/3f3d803b028f4ec4b5fe652865305d84
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54752 (2013)
Glioblastomas (GBMs) are characterized as highly invasive; the contribution of GBM stem-like cells (GSCs) to the invasive phenotype, however, has not been completely defined. Towards this end, we have defined the invasion potential of CD133+ GSCs and
Externí odkaz:
https://doaj.org/article/24a034c2741b48c2952d33c251a378a8