Zobrazeno 1 - 10
of 534
pro vyhledávání: '"P. J. Spencer"'
Autor:
Hasan U. Banna, Mary Slayo, James A. Armitage, Blanca del Rosal, Loretta Vocale, Sarah J. Spencer
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-16 (2024)
Abstract Recent years have seen significant advances in diagnostic testing of central nervous system (CNS) function and disease. However, there remain challenges in developing a comprehensive suite of non- or minimally invasive assays of neural healt
Externí odkaz:
https://doaj.org/article/73416239739549a38d73b5f59fc953b7
Autor:
Chuan-Mao Yang, Yi-Gang Xu, Xiao-Ping Xia, Jin-Hui Yang, Xiao-Long Huang, Christopher J. Spencer, Jin-Feng Sun, Qing Yang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Water is essential to the formation of intracontinental granites, but its origin remains elusive. Here we address this scientific problem by analyzing D/H isotopes of apatites, hydrous minerals in Jurassic and Early Cretaceous granites and b
Externí odkaz:
https://doaj.org/article/fbd2cb12155341d3b6c948c7bd5da77d
Autor:
Alex Z. Kadhim, Ben Vanderkruk, Samantha Mar, Meixia Dan, Katarina Zosel, Eric E. Xu, Rachel J. Spencer, Shugo Sasaki, Xuanjin Cheng, Shannon L. J. Sproul, Thilo Speckmann, Cuilan Nian, Robyn Cullen, Rocky Shi, Dan S. Luciani, Bradford G. Hoffman, Stefan Taubert, Francis C. Lynn
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Mediator, a co-regulator complex required for RNA Polymerase II activity, interacts with tissue-specific transcription factors to regulate development and maintain homeostasis. We observe reduced Mediator subunit MED15 expression in endocrin
Externí odkaz:
https://doaj.org/article/a99eab33e6ef46a1bcc1575a5001e336
Autor:
Shruthi Mohan, Shannon McNulty, Courtney Thaxton, Marwa Elnagheeb, Emma Owens, May Flowers, Teagan Nunnery, Autumn Self, Brooke Palus, Svetlana Gorokhova, April Kennedy, Zhiyv Niu, Mridul Johari, Alassane Baneye Maiga, Kelly Macalalad, Amanda R. Clause, Jacques S. Beckmann, Lucas Bronicki, Sandra T. Cooper, Vijay S. Ganesh, Peter B. Kang, Akanchha Kesari, Monkol Lek, Jennifer Levy, Laura Rufibach, Marco Savarese, Melissa J. Spencer, Volker Straub, Giorgio Tasca, Conrad C. Weihl
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 9, Pp 2268-2276 (2024)
Abstract Objective Limb girdle muscular dystrophies (LGMDs) are a group of genetically heterogeneous autosomal conditions with some degree of phenotypic homogeneity. LGMD is defined as having onset >2 years of age with progressive proximal weakness,
Externí odkaz:
https://doaj.org/article/d476e18b181c4fa5a1595ad8584a2ce4
Autor:
Richard J. Amedzrovi Agbesi, Amira El Merhie, Nick J. Spencer, Tim Hibberd, Nicolas R. Chevalier
Publikováno v:
Experimental Physiology, Vol 109, Iss 9, Pp 1545-1556 (2024)
Abstract Gut motility undergoes a switch from myogenic to neurogenic control in late embryonic development. Here, we report on the electrical events that underlie this transition in the enteric nervous system, using the GCaMP6f reporter in neural cre
Externí odkaz:
https://doaj.org/article/d2583cf24722482ba9c6194c05a68133
Autor:
Yixiao Wang, Silke Becker, Stella Finkelstein, Frank M. Dyka, Haitao Liu, Mark Eminhizer, Ying Hao, Richard S. Brush, William J. Spencer, Vadim Y. Arshavsky, John D. Ash, Jianhai Du, Martin-Paul Agbaga, Frans Vinberg, Jessica M. Ellis, Ekaterina S. Lobanova
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract The retina is light-sensitive neuronal tissue in the back of the eye. The phospholipid composition of the retina is unique and highly enriched in polyunsaturated fatty acids, including docosahexaenoic fatty acid (DHA). While it is generally
Externí odkaz:
https://doaj.org/article/ad85367e74fe4ef684827fbc22b57206
Autor:
Megan Copeland, Shelby Landa, Adekola Oluwatosin Owoyemi, Michelle M. Jonika, James M. Alfieri, J. Spencer Johnston, Terrence Pradakshana Sylvester, Bethany R. Kyre, Zachary Hoover, Carl E. Hjelmen, Lynne K. Rieske, Heath Blackmon, Claudio Casola
Publikováno v:
Royal Society Open Science, Vol 11, Iss 12 (2024)
Dendroctonus frontalis also known as southern pine beetle (SPB), is the most damaging insect forest pest in the southeastern United States. Genomic data are important to provide information on pest biology and to identify molecular targets to develop
Externí odkaz:
https://doaj.org/article/ff69216eab89454f92bd83645467050c
Autor:
Michael R. Emami, Mark A. Brimble, Alejandro Espinoza, Jane Owens, Laurence O. Whiteley, Sandra Casinghino, Thomas A. Lanz, Philip K. Farahat, Matteo Pellegrini, Courtney S. Young, Paul G. Thomas, Elizabeth M. McNally, S. Armando Villalta, Stefan A. Schattgen, Melissa J. Spencer
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101349- (2024)
Clinical trials for Duchenne muscular dystrophy (DMD) are assessing the therapeutic efficacy of systemically delivered adeno-associated virus (AAV) carrying a modified DMD transgene. High vector doses (>1E14 vg/kg) are needed to globally transduce sk
Externí odkaz:
https://doaj.org/article/fee20f3ef621479e9e7090e49aade946
Autor:
Larissa Marcely Gomes Cassiano, Karina Barbosa de Queiroz, Thais Veronez de Andrade Martins, Ana Luiza Azevedo Maia, Milene Alvarenga Rachid, Sarah J. Spencer, Roney Santos Coimbra
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundPneumococcal meningitis (PM) triggers apoptotic neuronal and progenitor cell death in the hippocampal dentate gyrus (DG), resulting in subsequent cognitive impairment. Microglia play a crucial role in PM-induced hippocampal damage. While th
Externí odkaz:
https://doaj.org/article/a78d738aedfd41a6a072d9bdf0112c78
A glycoprotein with anti-inflammatory properties secreted by an Aspergillus nidulans modified strain
Publikováno v:
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 13, Iss 2, Pp 527-543 (2007)
Total RNA from lipopolysaccharide (LPS)-stimulated rat macrophages used to treat protoplasts from an Aspergillus nidulans strain originated the RT2 regenerated strain, whose culture supernatant showed anti-inflammatory activity in Wistar rats. The pr
Externí odkaz:
https://doaj.org/article/93b8a7f215ab4e6e931ad65311b2d708