Zobrazeno 1 - 10
of 35
pro vyhledávání: '"P. J. Sharpe"'
Autor:
Lydia Qian, Nicola A. Scott, Isabelle M. Capell-Hattam, Eliza A. Draper, Nicole M. Fenton, Winnie Luu, Laura J. Sharpe, Andrew J. Brown
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 5, Pp 100362- (2023)
Cholesterol biosynthesis is a highly regulated pathway, with over 20 enzymes controlled at the transcriptional and posttranslational levels. While some enzymes remain stable, increased sterol levels can trigger degradation of several synthesis enzyme
Externí odkaz:
https://doaj.org/article/c248162951394c64a07c42242ea8d86c
Autor:
Isabelle M. Capell-Hattam, Nicole M. Fenton, Hudson W. Coates, Laura J. Sharpe, Andrew J. Brown
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 12, Pp 100295- (2022)
The enzymatic pathway of cholesterol biosynthesis has been well characterized. However, there remain several potential interacting proteins that may play ancillary roles in the regulation of cholesterol production. Here, we identified ERG28 (chromoso
Externí odkaz:
https://doaj.org/article/ed19bf38775a4237b40c5078c46e0707
Autor:
Iain M Hay, Katie E Mulholland, Tiffany Lai, Stephen C Graham, Hayley J Sharpe, Janet E Deane
Publikováno v:
eLife, Vol 11 (2022)
Protein tyrosine phosphatase receptor-type kappa (PTPRK) is a transmembrane receptor that links extracellular homophilic interactions to intracellular catalytic activity. Previously we showed that PTPRK promotes cell–cell adhesion by selectively de
Externí odkaz:
https://doaj.org/article/568308e577d14b4daa1cbcb5503554d2
Autor:
Christopher J Gabriel, Zachary Zeidler, Benita Jin, Changliang Guo, Caitlin M Goodpaster, Adrienne Q Kashay, Anna Wu, Molly Delaney, Jovian Cheung, Lauren E DiFazio, Melissa J Sharpe, Daniel Aharoni, Scott A Wilke, Laura A DeNardo
Publikováno v:
eLife, Vol 11 (2022)
Quantitative descriptions of animal behavior are essential to study the neural substrates of cognitive and emotional processes. Analyses of naturalistic behaviors are often performed by hand or with expensive, inflexible commercial software. Recently
Externí odkaz:
https://doaj.org/article/32813bdabc4e4f1b9dc0d73326bb57b4
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Receptor-linked protein tyrosine phosphatases (RPTPs) usually contain an active membrane proximal domain and an inactive pseudophosphatase domain. Here, the authors characterize an RPTP with two pseudophosphatase domains, providing evidence that it m
Externí odkaz:
https://doaj.org/article/43b379ce65a14ab3b79e3d114119ae48
Autor:
Melissa J. Sharpe, Hannah M. Batchelor, Lauren E. Mueller, Chun Yun Chang, Etienne J. P. Maes, Yael Niv, Geoffrey Schoenbaum
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Dopamine neurons are proposed to signal the reward prediction error in model-free reinforcement learning algorithms. Here, the authors show that when given during an associative learning task, optogenetic activation of dopamine neurons causes associa
Externí odkaz:
https://doaj.org/article/5731bc14a7b249e791e8968ac5facb69
Publikováno v:
Frontiers in Neuroanatomy, Vol 15 (2022)
In the retina, evolutionary changes can be traced in the topography of photoreceptors. The shape of the visual streak depends on the height of the animal and its habitat, namely, woods, prairies, or mountains. Also, the distribution of distinct wavel
Externí odkaz:
https://doaj.org/article/aa36d73539124c80abee176d71522fe1
Autor:
Chase B. Hellmer, Leo M. Hall, Jeremy M. Bohl, Zachary J. Sharpe, Robert G. Smith, Tomomi Ichinose
Publikováno v:
Cell Reports, Vol 37, Iss 11, Pp 110106- (2021)
Summary: Retinal bipolar cells are second-order neurons that transmit basic features of the visual scene to postsynaptic partners. However, their contribution to motion detection has not been fully appreciated. Here, we demonstrate that cholinergic f
Externí odkaz:
https://doaj.org/article/b408d13896d1477ab7a29e61919d42d2
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 15 (2021)
Higher-order conditioning involves learning causal links between multiple events, which then allows one to make novel inferences. For example, observing a correlation between two events (e.g., a neighbor wearing a particular sports jersey), later hel
Externí odkaz:
https://doaj.org/article/51a2c8f00a884e3da8592ad929ab9583
Autor:
Dane Cheasley, Matthew J. Wakefield, Georgina L. Ryland, Prue E. Allan, Kathryn Alsop, Kaushalya C. Amarasinghe, Sumitra Ananda, Michael S. Anglesio, George Au-Yeung, Maret Böhm, David D. L. Bowtell, Alison Brand, Georgia Chenevix-Trench, Michael Christie, Yoke-Eng Chiew, Michael Churchman, Anna DeFazio, Renee Demeo, Rhiannon Dudley, Nicole Fairweather, Clare G. Fedele, Sian Fereday, Stephen B. Fox, C Blake Gilks, Charlie Gourley, Neville F. Hacker, Alison M. Hadley, Joy Hendley, Gwo-Yaw Ho, Siobhan Hughes, David G. Hunstman, Sally M. Hunter, Tom W. Jobling, Kimberly R. Kalli, Scott H. Kaufmann, Catherine J. Kennedy, Martin Köbel, Cecile Le Page, Jason Li, Richard Lupat, Orla M. McNally, Jessica N. McAlpine, Anne-Marie Mes-Masson, Linda Mileshkin, Diane M. Provencher, Jan Pyman, Kurosh Rahimi, Simone M. Rowley, Carolina Salazar, Goli Samimi, Hugo Saunders, Timothy Semple, Ragwha Sharma, Alice J. Sharpe, Andrew N. Stephens, Niko Thio, Michelle C. Torres, Nadia Traficante, Zhongyue Xing, Magnus Zethoven, Yoland C. Antill, Clare L. Scott, Ian G. Campbell, Kylie L. Gorringe
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Whether mucinous ovarian carcinoma (MOC) arises from cells at the ovary or from metastases from other primary sites is an unanswered question. Here, Cheasley et al perform a genetic analysis of the disease, showing that MOC arises at the ovary.
Externí odkaz:
https://doaj.org/article/9047c1d475514bf5becaaddcde7c44d4