Zobrazeno 1 - 10
of 824
pro vyhledávání: '"P. J. Sharpe"'
Autor:
Eduardo H. Gilglioni, Ao Li, Wadsen St-Pierre-Wijckmans, Tzu-Keng Shen, Israel Pérez-Chávez, Garnik Hovhannisyan, Michela Lisjak, Javier Negueruela, Valerie Vandenbempt, Julia Bauzá-Martinez, Jose M. Herranz, Daria Ezeriņa, Stéphane Demine, Zheng Feng, Thibaut Vignane, Lukas Otero Sanchez, Flavia Lambertucci, Alena Prašnická, Jacques Devière, David C. Hay, Jose A. Encinar, Sumeet Pal Singh, Joris Messens, Milos R. Filipovic, Hayley J. Sharpe, Eric Trépo, Wei Wu, Esteban N. Gurzov
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Fat accumulation, de novo lipogenesis, and glycolysis are key drivers of hepatocyte reprogramming and the consequent metabolic dysfunction-associated steatotic liver disease (MASLD). Here we report that obesity leads to dysregulated expressi
Externí odkaz:
https://doaj.org/article/47d15d12bd9c4154ade149ceeddbddb9
Autor:
Lydia Qian, Nicola A. Scott, Isabelle M. Capell-Hattam, Eliza A. Draper, Nicole M. Fenton, Winnie Luu, Laura J. Sharpe, Andrew J. Brown
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 5, Pp 100362- (2023)
Cholesterol biosynthesis is a highly regulated pathway, with over 20 enzymes controlled at the transcriptional and posttranslational levels. While some enzymes remain stable, increased sterol levels can trigger degradation of several synthesis enzyme
Externí odkaz:
https://doaj.org/article/c248162951394c64a07c42242ea8d86c
Publikováno v:
Foot & Ankle Quarterly--The Seminar Journal; Summer2017, Vol. 28 Issue 2, p107-110, 4p
Autor:
Isabelle M. Capell-Hattam, Nicole M. Fenton, Hudson W. Coates, Laura J. Sharpe, Andrew J. Brown
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 12, Pp 100295- (2022)
The enzymatic pathway of cholesterol biosynthesis has been well characterized. However, there remain several potential interacting proteins that may play ancillary roles in the regulation of cholesterol production. Here, we identified ERG28 (chromoso
Externí odkaz:
https://doaj.org/article/ed19bf38775a4237b40c5078c46e0707
Akademický článek
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Autor:
Iain M Hay, Katie E Mulholland, Tiffany Lai, Stephen C Graham, Hayley J Sharpe, Janet E Deane
Publikováno v:
eLife, Vol 11 (2022)
Protein tyrosine phosphatase receptor-type kappa (PTPRK) is a transmembrane receptor that links extracellular homophilic interactions to intracellular catalytic activity. Previously we showed that PTPRK promotes cell–cell adhesion by selectively de
Externí odkaz:
https://doaj.org/article/568308e577d14b4daa1cbcb5503554d2
Autor:
Christopher J Gabriel, Zachary Zeidler, Benita Jin, Changliang Guo, Caitlin M Goodpaster, Adrienne Q Kashay, Anna Wu, Molly Delaney, Jovian Cheung, Lauren E DiFazio, Melissa J Sharpe, Daniel Aharoni, Scott A Wilke, Laura A DeNardo
Publikováno v:
eLife, Vol 11 (2022)
Quantitative descriptions of animal behavior are essential to study the neural substrates of cognitive and emotional processes. Analyses of naturalistic behaviors are often performed by hand or with expensive, inflexible commercial software. Recently
Externí odkaz:
https://doaj.org/article/32813bdabc4e4f1b9dc0d73326bb57b4
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Receptor-linked protein tyrosine phosphatases (RPTPs) usually contain an active membrane proximal domain and an inactive pseudophosphatase domain. Here, the authors characterize an RPTP with two pseudophosphatase domains, providing evidence that it m
Externí odkaz:
https://doaj.org/article/43b379ce65a14ab3b79e3d114119ae48
Autor:
Melissa J. Sharpe, Hannah M. Batchelor, Lauren E. Mueller, Chun Yun Chang, Etienne J. P. Maes, Yael Niv, Geoffrey Schoenbaum
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Dopamine neurons are proposed to signal the reward prediction error in model-free reinforcement learning algorithms. Here, the authors show that when given during an associative learning task, optogenetic activation of dopamine neurons causes associa
Externí odkaz:
https://doaj.org/article/5731bc14a7b249e791e8968ac5facb69
Publikováno v:
Frontiers in Neuroanatomy, Vol 15 (2022)
In the retina, evolutionary changes can be traced in the topography of photoreceptors. The shape of the visual streak depends on the height of the animal and its habitat, namely, woods, prairies, or mountains. Also, the distribution of distinct wavel
Externí odkaz:
https://doaj.org/article/aa36d73539124c80abee176d71522fe1