Zobrazeno 1 - 10
of 129
pro vyhledávání: '"P. J. Schofield"'
Autor:
Joanna Bonnici, Razanne Oueini, Eidarus Salah, Catrine Johansson, Elisabete Pires, Martine Abboud, Robert S. Dawber, Anthony Tumber, Patrick Rabe, Hilal Saraç, Christopher J. Schofield, Akane Kawamura
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract 2-Oxoglutarate (2OG) dependent N ε -methyl lysine demethylases (JmjC-KDMs) regulate eukaryotic transcription. We report studies showing that isolated forms of all human KDM4 and KDM5 JmjC enzymes catalyse demethylation of N-methylated Arg-3
Externí odkaz:
https://doaj.org/article/05b29963e9554ce083ab7680ddbc74cd
Autor:
Giorgia Fiorini, Stephen A. Marshall, William D. Figg, William K. Myers, Lennart Brewitz, Christopher J. Schofield
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Hypoxia inducible transcription factors (HIFs) mediate the hypoxic response in metazoans. When sufficient O2 is present, Fe(II)/2-oxoglutarate (2OG)-dependent oxygenases (human PHD1-3) promote HIFα degradation via prolyl-hydroxylation. We r
Externí odkaz:
https://doaj.org/article/38038eab48c0475db465b4d887b902a3
Autor:
Min Jung Kim, Daniel J. Gibson, Dan Hu, Tomoko Yoshida, Emily Hueske, Ayano Matsushima, Ara Mahar, Cynthia J. Schofield, Patlapa Sompolpong, Kathy T. Tran, Lin Tian, Ann M. Graybiel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract We recorded dopamine release signals in centromedial and centrolateral sectors of the striatum as mice learned consecutive versions of visual cue-outcome conditioning tasks. Dopamine release responses differed for the centromedial and centro
Externí odkaz:
https://doaj.org/article/9bd00f3f12fa4759b3c56f138ffb017e
Autor:
Petra L. Graham, Deborah J. Schofield, Robert J. Tait, Sarita Bista, Rebecca Q. Ivers, Bette Liu, Sharyn Lymer, Jennifer L. Marino, Lena A. Sanci, Rupendra N. Shrestha, Katharine Steinbeck, Leon M. Straker, S. Rachel Skinner
Publikováno v:
BMC Public Health, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background Higher educational attainment is important for economic wellbeing and associated with better health and longevity. Previous research focused on intelligence, socioeconomic status and mental health or individual risk behaviours as
Externí odkaz:
https://doaj.org/article/1688bc87e30846f99c6772e1303a5f1d
Autor:
Christopher E. L. Owens, Owen Tan, Joice Kuroiwa-Trzmielina, Rupendra N. Shrestha, Tracey O’Brien, Vanessa Tyrrell, Deborah J. Schofield
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-8 (2024)
Abstract Embedding precision medicine in paediatric oncology shows promise to have a positive impact on how children with cancer will be treated in the future. While there are a number of studies of precision medicine in childhood cancer, there is li
Externí odkaz:
https://doaj.org/article/fad2a932cf20404b9f3557c987f4906d
Autor:
Mariska de Munnik, Pauline A. Lang, Karina Calvopiña, Patrick Rabe, Jürgen Brem, Christopher J. Schofield
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract The essential l,d-transpeptidase of Mycobacterium tuberculosis (LdtMt2) catalyses the formation of 3 $$\to$$ → 3 cross-links in cell wall peptidoglycan and is a target for development of antituberculosis therapeutics. Efforts to inhibit Ld
Externí odkaz:
https://doaj.org/article/1e73630de0924f099b634058bd952bf2
Autor:
Rongling Wang, Mario Gomez Salazar, Iris Pruñonosa Cervera, Amanda Coutts, Karen French, Marlene Magalhaes Pinto, Sabrina Gohlke, Ruben García-Martín, Matthias Blüher, Christopher J. Schofield, Ioannis Kourtzelis, Roland H. Stimson, Cécile Bénézech, Mark Christian, Tim J. Schulz, Elias F. Gudmundsson, Lori L. Jennings, Vilmundur G. Gudnason, Triantafyllos Chavakis, Nicholas M. Morton, Valur Emilsson, Zoi Michailidou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Enhancing thermogenic brown adipose tissue (BAT) function is a promising therapeutic strategy for metabolic disease. However, predominantly thermoneutral modern human living conditions deactivate BAT. We demonstrate that selective adipocyte
Externí odkaz:
https://doaj.org/article/1825f418498f427ea1d3d8694a180918
Autor:
Yuting Lu, Jana Travnickova, Mihaly Badonyi, Florian Rambow, Andrea Coates, Zaid Khan, Jair Marques, Laura C. Murphy, Pablo Garcia-Martinez, Richard Marais, Pakavarin Louphrasitthiphol, Alex H.Y. Chan, Christopher J. Schofield, Alex von Kriegsheim, Joseph A. Marsh, Valeria Pavet, Owen J. Sansom, Robert S. Illingworth, E. Elizabeth Patton
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114927- (2024)
Externí odkaz:
https://doaj.org/article/a0bd1226210f449ba3106f231ea41cf1
Autor:
Lonnie P. Swift, B. Christoffer Lagerholm, Lucy R. Henderson, Malitha Ratnaweera, Hannah T. Baddock, Blanka Sengerova, Sook Lee, Abimael Cruz-Migoni, Dominic Waithe, Christian Renz, Helle D. Ulrich, Joseph A. Newman, Christopher J. Schofield, Peter J. McHugh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract DNA double-strand breaks (DSBs), such as those produced by radiation and radiomimetics, are amongst the most toxic forms of cellular damage, in part because they involve extensive oxidative modifications at the break termini. Prior to comple
Externí odkaz:
https://doaj.org/article/cd10c307980d47f8a16e6289838eff95
Autor:
Rupendra Shrestha, Lennert Veerman, Megan Passey, Deborah J Schofield, Robert Tanton, Simon J Kelly, Katherine Lim
Publikováno v:
BMJ Open, Vol 14, Iss 5 (2024)
Objectives To estimate the economic burden of informal caregivers not in the labour force (NILF) due to caring for a person with arthritis in Australia, with projections of these costs from 2015 to 2030.Design Static microsimulation modelling using n
Externí odkaz:
https://doaj.org/article/1bf81007a7c9476f916cf7b01eb2e539