Zobrazeno 1 - 10
of 17
pro vyhledávání: '"P. J. Saker"'
Autor:
I. S. Farooqi, David Halsall, P J Saker, Stephen O'Rahilly, Julia M. Keogh, S. J. Huxtable, Nicholas J. Wareham, Jian'an Luan
Publikováno v:
International Journal of Obesity. 25:472-477
OBJECTIVE: To investigate whether genetic variation at the UCP3 locus contributes to human obesity. SUBJECTS: Ninety-one obese children (BMI>4 standard deviations from age related mean) and 419 Caucasian adults from the Isle of Ely Study. DESIGN: Sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf2665417bc408f637fae8ae62232d2
https://doi.org/10.1038/sj.ijo.0801584
https://doi.org/10.1038/sj.ijo.0801584
Autor:
M S Hammersley, V A Horton, M. D. Gillmer, Robert C. Turner, B A Barrow, Andrew T. Hattersley, P. J. Saker
Publikováno v:
Diabetic Medicine. 14:42-45
Some patients with Type 2 (non-insulin-dependent) diabetes mellitus possess a mitochondrial mutation in the tRNALeu(UUR) gene at position 3243 bp. These subjects show a maternal mode of inheritance and often have hearing defects. In French and Japane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57f25f799804d7e3fc48eb9ab0a4a597
https://doi.org/10.1002/(sici)1096-9136(199701)14:1<42::aid-dia295>3.0.co
https://doi.org/10.1002/(sici)1096-9136(199701)14:1<42::aid-dia295>3.0.co
Autor:
R. G. Firth, Y. Zhang, R. C. Turner, Markus Stoffel, J. T. E. Cook, M. Warren-Perry, P. J. Saker, Andrew T. Hattersley
Publikováno v:
Diabetologia. 37:721-724
Glucagon-like peptide-1 (GLP-1) is a hormone derived from the preproglucagon molecule that is secreted by intestinal L cells and stimulates insulin secretion from beta cells. The GLP-1 receptor is a candidate gene for diabetes mellitus, as mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa2465b5a0959a8dc4412ec15d850f26
https://doi.org/10.1007/bf00417698
https://doi.org/10.1007/bf00417698
Autor:
P J, Saker
Publikováno v:
Methods in molecular medicine. 16
Screening for mutations prior to sequencing can reduce the time and costs of identifying mutations. When the DNA sequence is known, the technique of detecting mutations as single-stranded conformational polymorphisms (SSCP) is a convenient method of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::017ce73a56725ffe721bff36b0bf72d5
https://pubmed.ncbi.nlm.nih.gov/21390774
https://pubmed.ncbi.nlm.nih.gov/21390774
Autor:
M. G. Warren-Perry, M. Stoffel, P. J. Saker, Y. Zhang, L. J. Brown, M. J. MacDonald, R. C. Turner
Publikováno v:
Diabetes. 45:639-641
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::020caefab95f7337da4128b44a03fc20
https://doi.org/10.2337/diabetes.45.5.639
https://doi.org/10.2337/diabetes.45.5.639
Autor:
P J Saker
Screening for mutations prior to sequencing can reduce the time and costs of identifying mutations. When the DNA sequence is known, the technique of detecting mutations as single-stranded conformational polymorphisms (SSCP) is a convenient method of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::012f932dda3880d898ccc95fb9414d07
https://doi.org/10.1385/0-89603-499-2:39
https://doi.org/10.1385/0-89603-499-2:39
Autor:
Lisa I.S. Allen, S. J. Huxtable, Andrew T. Hattersley, Eleni Kousta, P J Saker, Mark I. McCarthy, Sian Ellard
Publikováno v:
Diabetic medicine : a journal of the British Diabetic Association. 18(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4022f5b59cd80192c4b92e0dd65ef4fd
https://pubmed.ncbi.nlm.nih.gov/11553210
https://pubmed.ncbi.nlm.nih.gov/11553210
Autor:
Pamidighantam V. Subba Rao, Stephen O'Rahilly, Terence J. Wilkin, Mark I. McCarthy, Graham A. Hitman, Sian Ellard, Christopher Fletcher, Marie Wishart, Elizabeth C. Jones, Stephan Menzel, Nancy J. Cox, Graeme I. Bell, Philip Prestwich, Jonathan C. Levy, Mark Walker, Paul G. Cassell, Ranjit Dhillon, Yukio Horikawa, Ann Millward, Amanda J. Bennett, Timothy M. Frayling, Andrew T. Hattersley, Andrew G. Demaine, P J Saker, Julie Evans, Nikol Simecek
Publikováno v:
American journal of human genetics. 69(3)
Variation in CAPN10, the gene encoding the ubiquitously expressed cysteine protease calpain-10, has been associated with type 2 diabetes in Mexican Americans and in two northern-European populations, from Finland and Germany. We have studied CAPN10 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812bdd3b42625518e200ef10ea2ce672
http://ora.ox.ac.uk/objects/uuid:29e71b2e-9bbe-4413-81ba-46a6cb6e70d7
http://ora.ox.ac.uk/objects/uuid:29e71b2e-9bbe-4413-81ba-46a6cb6e70d7
Autor:
C. Snehelatha, Mark I. McCarthy, S. J. Huxtable, Eleni Kousta, A. Ramachandran, Marjorie M. Walker, Graham A. Hitman, Paul G. Cassell, Timothy M. Frayling, P. G. Kopelman, Andrew T. Hattersley, Alan E. Jackson, P J Saker
Publikováno v:
Diabetologia. 43(12)
Aims/hypothesis. Uncoupling proteins are mitochondrial transmembrane carriers implicated in the regulation of energy balance. Dysfunction of UCP3 (the predominant uncoupling protein in skeletal muscle) might therefore be expected to reduce thermogeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab2d9431e862f2176c35808636fbefff
https://pubmed.ncbi.nlm.nih.gov/11151767
https://pubmed.ncbi.nlm.nih.gov/11151767
Autor:
L. Albon, Juliet L. Easlick, A. Qureshi, Paul G. Cassell, Claire Pecqueur, Maria Neverova, Daniel Ricquier, N. Uwakwe, A. Ramachandran, S. Janmohamed, Chamukuttan Snehalatha, P. G. Kopelman, Craig H Warden, Mark I. McCarthy, P J Saker, Kate Noonan, Graham A. Hitman
Publikováno v:
Diabetologia. 42(6)
Aims/hypothesis. Linkage between markers close to the uncoupling protein 2 and 3 genes (11q13) and resting metabolic rate and a pre-diabetic phenotype have been found. The syntenic region in mouse has been found to be linked to quantitative traits as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e73d4dc3a08c0c638d31534c09040db
https://pubmed.ncbi.nlm.nih.gov/10382588
https://pubmed.ncbi.nlm.nih.gov/10382588