Výsledky vyhledávání - "P. J. REIDER"

Akademický článek

Tofacitinib-Induced Modulation of Intestinal Adaptive and Innate Immunity and Factors Driving Cellular and Systemic PharmacokineticsSummary

Autor: Bernhard Texler, Andreas Zollner, Vera Reinstadler, Simon J. Reider, Sophie Macheiner, Barbara Jelusic, Alexandra Pfister, Christina Watschinger, Nicole Przysiecki, Herbert Tilg, Herbert Oberacher, Alexander R. Moschen

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 383-404 (2022)

Objective: By interfering with multiple cytokines, human Janus kinase inhibitors (JAKis) are of growing importance in the treatment of malignant and inflammatory conditions. Although tofacitinib has demonstrated efficacy as the first-in-class JAKi in

Externí odkaz: https://doaj.org/article/75ec781f198045779141e7f5bdbf87be

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Akademický článek

Prebiotic Effects of Partially Hydrolyzed Guar Gum on the Composition and Function of the Human Microbiota—Results from the PAGODA Trial

Autor: Simon J. Reider, Simon Moosmang, Judith Tragust, Lovro Trgovec-Greif, Simon Tragust, Lorenz Perschy, Nicole Przysiecki, Sonja Sturm, Herbert Tilg, Hermann Stuppner, Thomas Rattei, Alexander R. Moschen

Publikováno v: Nutrients, Vol 12, Iss 5, p 1257 (2020)

(1) Background: Alterations in the structural composition of the human gut microbiota have been identified in various disease entities along with exciting mechanistic clues by reductionist gnotobiotic modeling. Improving health by beneficially modula

Externí odkaz: https://doaj.org/article/867711f309b849ee936466561e8d260a

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Akademický článek

Targeting NAD+ metabolism in the human malaria parasite Plasmodium falciparum.

Autor: Jessica K O'Hara, Lewis J Kerwin, Simon A Cobbold, Jonathan Tai, Thomas A Bedell, Paul J Reider, Manuel Llinás

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e94061 (2014)

Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite utilized as a redox cofactor and enzyme substrate in numerous cellular processes. Elevated NAD+ levels have been observed in red blood cells infected with the malaria parasite Plasmo

Externí odkaz: https://doaj.org/article/5c0c089a5ad84b00ba114be7484d47eb

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Akademický článek

Advances in AIDS Chemotherapy: The Asymmetric Synthesis of CRIXIVAN®

Autor: Paul J. Reider

Publikováno v: CHIMIA, Vol 51, Iss 6 (1997)

The discovery and development of an efficient, practical asymmetric synthesis of the HIV Protease inhibitor CRIXIVAN® is described. Particular emphasis is placed on the selective installation of each of the five stereogenic centers as well as design

Externí odkaz: https://doaj.org/article/8b77da4986c24d2b81386cd207e77970

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