Zobrazeno 1 - 10
of 18
pro vyhledávání: '"P. J. R. Goulder"'
Autor:
Vinicius A Vieira, Emily Adland, David F G Malone, Maureen P Martin, Andreas Groll, M Azim Ansari, Maria C Garcia-Guerrero, Mari C Puertas, Maximilian Muenchhoff, Claudia Fortuny Guash, Christian Brander, Javier Martinez-Picado, Alasdair Bamford, Gareth Tudor-Williams, Thumbi Ndung'u, Bruce D Walker, Veron Ramsuran, John Frater, Pieter Jooste, Dimitra Peppa, Mary Carrington, Philip J R Goulder
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11, p e1010090 (2021)
Natural Killer (NK) cells contribute to HIV control in adults, but HLA-B-mediated T-cell activity has a more substantial impact on disease outcome. However, the HLA-B molecules influencing immune control in adults have less impact on paediatric infec
Externí odkaz:
https://doaj.org/article/2772898860cf475e98f5416e7e2940e4
Autor:
Anna L. McNaughton, José Lourenço, Louise Hattingh, Emily Adland, Samantha Daniels, Anriette Van Zyl, Connie S. Akiror, Susan Wareing, Katie Jeffery, M. Azim Ansari, Paul Klenerman, Philip J. R. Goulder, Sunetra Gupta, Pieter Jooste, Philippa C. Matthews
Publikováno v:
BMC Medicine, Vol 17, Iss 1, Pp 1-15 (2019)
Abstract Background Sustainable Development Goals set a challenge for the elimination of hepatitis B virus (HBV) infection as a public health concern by the year 2030. Deployment of a robust prophylactic vaccine and enhanced interventions for prevent
Externí odkaz:
https://doaj.org/article/4468152a22c84751804e467d341e08ce
Autor:
M. Muenchhoff, A. W. Chung, J. Roider, Anne-Sophie Dugast, Simone Richardson, Henrik Kløverpris, Alasdair Leslie, Thumbi Ndung’u, Penny Moore, Galit Alter, Philip J. R. Goulder
Publikováno v:
mSphere, Vol 5, Iss 6 (2020)
ABSTRACT A prophylactic HIV vaccine would ideally induce protective immunity prior to sexual debut. Children develop broadly neutralizing antibody (bnAb) responses faster and at higher frequencies than adults, but little is known about the underlying
Externí odkaz:
https://doaj.org/article/f66d862dd1194fa4867e6134d3109279
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1008607 (2020)
Externí odkaz:
https://doaj.org/article/b5ddb0439f0e4bccbab951aaff832f37
Autor:
Jacqui Brener, Astrid Gall, Jacob Hurst, Rebecca Batorsky, Nora Lavandier, Fabian Chen, Anne Edwards, Chrissy Bolton, Reena Dsouza, Todd Allen, Oliver G. Pybus, Paul Kellam, Philippa C. Matthews, Philip J. R. Goulder
Publikováno v:
Retrovirology, Vol 15, Iss 1, Pp 1-13 (2018)
Abstract Background The factors determining differential HIV disease outcome among individuals expressing protective HLA alleles such as HLA-B*27:05 and HLA-B*57:01 remain unknown. We here analyse two HIV-infected subjects expressing both HLA-B*27:05
Externí odkaz:
https://doaj.org/article/5fc6d4b84d414835beab40dcb90f9e9a
Autor:
Julia Roider, J. Zachary Porterfield, Paul Ogongo, Maximilian Muenchhoff, Emily Adland, Andreas Groll, Lynn Morris, Penny L. Moore, Thumbi Ndung'u, Henrik Kløverpris, Philip J. R. Goulder, Alasdair Leslie
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Children may be the optimal target for HIV vaccine development as they generate substantially more frequent and more potent broadly HIV neutralizing antibodies (bnAbs) than adults. Development of a biomarker that correlates with neutralization breadt
Externí odkaz:
https://doaj.org/article/3dc003b8e8b54d888af33464a1bb7621
Autor:
Amna Malik, Emily Adland, Leana Laker, Henrik Kløverpris, Rabiah Fardoos, Julia Roider, Mai C Severinsen, Fabian Chen, Lynn Riddell, Anne Edwards, Søren Buus, Pieter Jooste, Philippa C Matthews, Philip J R Goulder
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189612 (2017)
More than 90% of children in Africa are infected with cytomegalovirus (CMV) by the age of 12 months. However, the high-frequency, immunodominant CD8+ T-cell responses that control CMV infection have not been well studied in African populations. We th
Externí odkaz:
https://doaj.org/article/942e82a2136f45a9bd074e2ade0a2d29
Autor:
Ellen M Leitman, Christine D Palmer, Søren Buus, Fabian Chen, Lynn Riddell, Stuart Sims, Paul Klenerman, Asier Sáez-Cirión, Bruce D Walker, Paul R Hess, Marcus Altfeld, Philippa C Matthews, Philip J R Goulder
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0184496 (2017)
Antigen-specific T-cells are highly variable, spanning potent antiviral efficacy and damaging auto-reactivity. In virus infections, identifying the most efficacious responses is critical to vaccine design. However, current methods depend on indirect
Externí odkaz:
https://doaj.org/article/fb7a3d6217b74a1fa025d6dc51b45b58
Autor:
Philippa C. Matthews, Colin P. Sharp, Amna Malik, William F. Gregory, Emily Adland, Pieter Jooste, Philip J. R. Goulder, Peter Simmonds, Paul Klenerman
Publikováno v:
Emerging Infectious Diseases, Vol 21, Iss 4, Pp 713-715 (2015)
Externí odkaz:
https://doaj.org/article/800682d27d7a408ea3ec81ba2a1ce916
Autor:
Prakash K Gupta, Jernej Godec, David Wolski, Emily Adland, Kathleen Yates, Kristen E Pauken, Cormac Cosgrove, Carola Ledderose, Wolfgang G Junger, Simon C Robson, E John Wherry, Galit Alter, Philip J R Goulder, Paul Klenerman, Arlene H Sharpe, Georg M Lauer, W Nicholas Haining
Publikováno v:
PLoS Pathogens, Vol 11, Iss 10, p e1005177 (2015)
Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of exhaustion is important both for identifying and potentially reversing T cell exhaustion. H
Externí odkaz:
https://doaj.org/article/a33577d938d04eef98014e4ae8a823b4