Zobrazeno 1 - 10
of 18
pro vyhledávání: '"P. J. R. Bevis"'
Publikováno v:
Scopus-Elsevier
Aims The aim of the present study was to determine how the pharmacokinetics of meloxicam are affected by kidney dysfunction and consequently to define the appropriate dose for the use of meloxicam in patients with mild or moderate renal impairment. M
Publikováno v:
Rheumatology. 35:56-60
Meloxicam is a new non-steroidal anti-inflammatory drug (NSAID) which has shown potent anti-inflammatory properties but good gastrointestinal (GI) renal tolerability. The safety and tolerability profile of orally administered meloxicam 15 mg given on
Autor:
P. J. R. Bevis, E. Bluhmki, X. Le Loët, M. Distel, M. Schattenkirchner, J.A. Wojtulewski, P. Barceló
Publikováno v:
Rheumatology. 35:22-28
SUMMARY Meloxicam is a new non-steroidal anti-inflammatory drug (NSAID) which preferentially inhibits cyclooxygenase-2 over cyclooxygenase-1. A double-blind, parallel-group trial compared meloxicam 7.5 mg once daily (n = 199) with naproxen 750 mg (n
Publikováno v:
Experimental Physiology. 78:183-196
We have performed a set of independent studies on the effects of the circulating pancreatic polypeptide, amylin, on rat osteoclast function, in vitro. Time-lapse video observations, measuring cell protrusions and retraction, showed that 250 nmol l-1
Autor:
Mone Zaidi, Harish K. Datta, Iain MacIntyre, P. J. R. Bevis, Baljit S. Moonga, Christopher L.-H. Huang
Publikováno v:
Experimental Physiology. 76:923-933
The effects of perchlorate anion (ClO4-) on osteoclast properties were investigated through a number of independent in vivo and in vitro procedures. Intravenous infusion of ClO4- significantly reduced plasma [Ca] in young (50 g) Wistar rats, in the a
Autor:
P. J. R. Bevis, F. Avaldi, Baljit S. Moonga, R. Soncini, Christopher L.-H. Huang, A. S. M. T. Alam, Mone Zaidi
Publikováno v:
The Journal of endocrinology. 132(2)
It is now established that calcium is a second messenger mediating the action of calcitonin on the osteoclast. We have demonstrated that an increase in the concentration of intracellular free calcium ([Ca2+]i) is associated with (and possibly mediate
Publikováno v:
Scopus-Elsevier
Amylin-amide is a new member of the family of peptides encoded by the calcitonin multigene complex. In the present study, we have compared directly, the hypocalcaemic potency and duration of action of human amylin-amide and human calcitonin in an in
Publikováno v:
Experimental physiology. 75(1)
In the present study we have evaluated the effect of calcitonin gene-related peptide (CGRP) on cyclic AMP levels in intact mouse kidneys. We have used an in vivo bioassay based on microwave irradiation as a means of rapid tissue fixation, followed by
Autor:
Timothy J. Chambers, Mone Zaidi, P. J. R. Bevis, Iain MacIntyre, K. Fuller, Rose E. GainesDas
Publikováno v:
Calcified Tissue International. 40:149-154
Besides the calcitonin (CT) precursor, the calcitonin gene also encodes another peptide--calcitonin gene-related peptide (CGRP). We have previously reported that CGRP lowers plasma calcium in the rat. In the present study we have evaluated the effect
Autor:
Rose E. Gaines Das, Timothy J. Chambers, Mone Zaidi, P. J. R. Bevis, Jeremy L. Beacham, Iain MacIntyre
Publikováno v:
Quarterly Journal of Experimental Physiology. 73:471-485
The calcitonin-calcitonin gene-related peptide (CGRP) gene complex encodes a family of novel peptides--calcitonin, CGRP and katacalcin. Whereas calcitonin is a circulating hormone involved in skeletal maintenance, the physiological function of CGRP s