Zobrazeno 1 - 10
of 20
pro vyhledávání: '"P. J. Paddison"'
Autor:
J. Mathieu, D. Detraux, D. Kuppers, Y. Wang, C. Cavanaugh, S. Sidhu, S. Levy, A. M. Robitaille, A. Ferreccio, T. Bottorff, A. McAlister, L. Somasundaram, F. Artoni, S. Battle, R. D. Hawkins, R. T. Moon, C. B. Ware, P. J. Paddison, H. Ruohola-Baker
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The pathways involved in exit from pluripotency in human embryonic stem cells are poorly understood. Here, the authors performed a CRISPR-based screen to identify genes that promote exit from naïve pluripotency and find a role for folliculin (FLCN)
Externí odkaz:
https://doaj.org/article/d50b9ac4e8764f89b3e5badb92229b82
Autor:
Ivan Popov, Zhenghao Zhu, Amanda R. Young-Gonzales, Robert L. Sacci, Eugene Mamontov, Catalin Gainaru, Stephen J. Paddison, Alexei P. Sokolov
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract The transport of protons is critical in a variety of bio- and electro-chemical processes and technologies. The Grotthuss mechanism is considered to be the most efficient proton transport mechanism, generally implying a transfer of protons be
Externí odkaz:
https://doaj.org/article/73fa4872fdaf4d58b14f836ccfb0e949
Autor:
Samantha L. Schuster, Sonali Arora, Cynthia L. Wladyka, Pushpa Itagi, Lukas Corey, Dave Young, Bethany L. Stackhouse, Lori Kollath, Qian V. Wu, Eva Corey, Lawrence D. True, Gavin Ha, Patrick J. Paddison, Andrew C. Hsieh
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112840- (2023)
Summary: 3′ untranslated region (3′ UTR) somatic mutations represent a largely unexplored avenue of alternative oncogenic gene dysregulation. To determine the significance of 3′ UTR mutations in disease, we identify 3′ UTR somatic variants ac
Externí odkaz:
https://doaj.org/article/8788ab3aff1444089f1efea108c27405
Autor:
Daniel A Kuppers, Jonathan Linton, Sergio Ortiz Espinosa, Kelly M McKenna, Anthony Rongvaux, Patrick J Paddison
Publikováno v:
PLoS ONE, Vol 18, Iss 6, p e0287052 (2023)
Human CD34+ hematopoietic stem and progenitor cells (HSPCs) are a standard source of cells for clinical HSC transplantations as well as experimental xenotransplantation to generate "humanized mice". To further extend the range of applications of thes
Externí odkaz:
https://doaj.org/article/c40eaaf9412747dea3045397d9b776a9
Autor:
Emily Hsieh, Derek H Janssens, Patrick J Paddison, Edward P Browne, Steve Henikoff, Molly OhAinle, Michael Emerman
Publikováno v:
PLoS Pathogens, Vol 19, Iss 1, p e1011101 (2023)
Transcriptional silencing of latent HIV-1 proviruses entails complex and overlapping mechanisms that pose a major barrier to in vivo elimination of HIV-1. We developed a new latency CRISPR screening strategy, called Latency HIV-CRISPR which uses the
Externí odkaz:
https://doaj.org/article/5cef2c8dd6f648b190d059c1fefe11f9
Autor:
Samantha A O’Connor, Heather M Feldman, Sonali Arora, Pia Hoellerbauer, Chad M Toledo, Philip Corrin, Lucas Carter, Megan Kufeld, Hamid Bolouri, Ryan Basom, Jeffrey Delrow, José L McFaline‐Figueroa, Cole Trapnell, Steven M Pollard, Anoop Patel, Patrick J Paddison, Christopher L Plaisier
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 6, Pp 1-29 (2021)
Abstract Single‐cell RNA sequencing has emerged as a powerful tool for resolving cellular states associated with normal and maligned developmental processes. Here, we used scRNA‐seq to examine the cell cycle states of expanding human neural stem
Externí odkaz:
https://doaj.org/article/58249d732dc642c29b1b9c5be97d78eb
Autor:
Zhenghao Zhu, Stephen J. Paddison
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Ion-containing polymers are soft materials composed of polymeric chains and mobile ions. Over the past several decades they have been the focus of considerable research and development for their use as the electrolyte in energy conversion and storage
Externí odkaz:
https://doaj.org/article/4d3f29ab184c413dbbb72a9dc0eb7e89
Autor:
Christopher Hubert, Kelly Mitchell, Samuel Sprowls, Sajina Shakya, Sonali Arora, Daniel J. Silver, Christopher M. Goins, Lisa Wallace, Gustavo Roversi, Rachel Schafer, Kristen Kay, Tyler E. Miller, Adam Lauko, John Bassett, Anjali Kashyap, J. D’Amato Kass, Erin E. Mulkearns-Hubert, Sadie Johnson, Joseph Alvarado, Jeremy N. Rich, Patrick J. Paddison, Anoop P. Patel, Shaun R. Stauffer, Christopher G. Hubert, Justin D. Lathia
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 107-107 (2023)
OBJECTIVES/GOALS: Glioblastomas (GBMs) are heterogeneous, treatment-resistant tumors that are driven by populations of cancer stem cells (CSCs). In this study, we perform an epigenetic-focused functional genomics screen in GBM organoids and identify
Externí odkaz:
https://doaj.org/article/38b0f34846504b9fac37c7e24f076612
Autor:
H Nayanga Thirimanne, Feinan Wu, Derek H Janssens, Jherek Swanger, Ahmed Diab, Heather M Feldman, Robert A Amezquita, Raphael Gottardo, Patrick J Paddison, Steven Henikoff, Bruce E Clurman
Publikováno v:
eLife, Vol 11 (2022)
The Fbw7 ubiquitin ligase targets many proteins for proteasomal degradation, which include oncogenic transcription factors (TFs) (e.g., c-Myc, c-Jun, and Notch). Fbw7 is a tumor suppressor and tumors often contain mutations in FBXW7, the gene that en
Externí odkaz:
https://doaj.org/article/04134ed54862435e8033d1ac577697c2
Autor:
Jay F Sarthy, Michael P Meers, Derek H Janssens, Jorja G Henikoff, Heather Feldman, Patrick J Paddison, Christina M Lockwood, Nicholas A Vitanza, James M Olson, Kami Ahmad, Steven Henikoff
Publikováno v:
eLife, Vol 9 (2020)
Lysine 27-to-methionine (K27M) mutations in the H3.1 or H3.3 histone genes are characteristic of pediatric diffuse midline gliomas (DMGs). These oncohistone mutations dominantly inhibit histone H3K27 trimethylation and silencing, but it is unknown ho
Externí odkaz:
https://doaj.org/article/e7dfecb6026a4b9d88e0f6a2bde980c7