Zobrazeno 1 - 10
of 68
pro vyhledávání: '"P. J. Mulholland"'
Autor:
Patrick J. Mulholland, Audrey E. Padula, Larry J. Wilhelm, Byung Park, Kathleen A. Grant, Betsy M. Ferguson, Rita Cervera-Juanes
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The underlying genetic and epigenetic mechanisms driving functional adaptations in neuronal excitability and excessive alcohol intake are poorly understood. Small-conductance Ca2+-activated K+ (KCa2 or SK) channels encoded by the KCNN family
Externí odkaz:
https://doaj.org/article/0f5f2a56dec54ef883fca75ec810d00c
Autor:
Helen M. Deeks, Kirill Zinovjev, Jonathan Barnoud, Adrian J. Mulholland, Marc W. van der Kamp, David R. Glowacki
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract We describe a two-step approach for combining interactive molecular dynamics in virtual reality (iMD-VR) with free energy (FE) calculation to explore the dynamics of biological processes at the molecular level. We refer to this combined appr
Externí odkaz:
https://doaj.org/article/60f7f91f6cae4fdcb4ced23c5de8bc8f
Autor:
Katharine A. Barrett, Francis Jacob Kassama, William Surks, Andrew J. Mulholland, Karen D. Moulton, Danielle H. Dube
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
IntroductionThe pathogenic bacterium Helicobacter pylori has evolved glycan-mediated mechanisms to evade host immune defenses. This study tests the hypothesis that genetic disruption of H. pylori glycan biosynthesis alters immune recognition and resp
Externí odkaz:
https://doaj.org/article/e690178a884a41e28a98a60f5f828bf9
Publikováno v:
Biological Imaging, Vol 4 (2024)
Imaging platforms for generating highly multiplexed histological images are being continually developed and improved. Significant improvements have also been made in the accuracy of methods for automated cell segmentation and classification. However,
Externí odkaz:
https://doaj.org/article/f9de153b25ec4024a816ba01e8a5871e
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Drivers have different visual demands across varying contrast and luminance conditions. However, vision assessments for driving are typically conducted under photopic conditions. This study investigated the sensitivity of photopic and mesopi
Externí odkaz:
https://doaj.org/article/8d955f21916a44e9be8692d07f649b78
Autor:
Shai White-Gilbertson, Ping Lu, Ikechukwu Esobi, Jing Echesabal-Chen, Patrick J. Mulholland, Monika Gooz, Besim Ogretmen, Alexis Stamatikos, Christina Voelkel-Johnson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Polyploid Giant Cancer Cells (PGCC) are increasingly being recognized as drivers of cancer recurrence. Therapy stress promotes the formation of these cells, which upon stress cessation often successfully generate more aggressive progeny that
Externí odkaz:
https://doaj.org/article/5d19c7a7507b474aa3ac89418fd4a9ad
Autor:
Christopher Soliman, Henry Y.C. Pan, Clancy J. Mulholland, Marc A. Furrer, Dinesh K. Agarwal, Nathan Lawrentschuk, Niranjan J. Sathianathen
Publikováno v:
Investigative and Clinical Urology, Vol 63, Iss 3, Pp 273-284 (2022)
Purpose: Urethral stricture disease is common and has high associated morbidity and impact on quality-of-life. This systematic review and meta-analysis aims to summarise current evidence on the efficacy of local urethral steroids post-direct vision i
Externí odkaz:
https://doaj.org/article/3551f9e8851340c9867630bde72d6d8b
Autor:
A. Sofia F. Oliveira, Deborah K. Shoemark, Amaurys Avila Ibarra, Andrew D. Davidson, Imre Berger, Christiane Schaffitzel, Adrian J. Mulholland
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 139-147 (2022)
The SARS-CoV-2 spike protein is the first contact point between the SARS-CoV-2 virus and host cells and mediates membrane fusion. Recently, a fatty acid binding site was identified in the spike (Toelzer et al. Science 2020). The presence of linoleic
Externí odkaz:
https://doaj.org/article/7a4e5a4ce4ed4c9c9f8922f51cdeada1
Autor:
Kapil Gupta, Christine Toelzer, Maia Kavanagh Williamson, Deborah K. Shoemark, A. Sofia F. Oliveira, David A. Matthews, Abdulaziz Almuqrin, Oskar Staufer, Sathish K. N. Yadav, Ufuk Borucu, Frederic Garzoni, Daniel Fitzgerald, Joachim Spatz, Adrian J. Mulholland, Andrew D. Davidson, Christiane Schaffitzel, Imre Berger
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
BriSΔ, a SARS-CoV-2 variant from clinical isolate hCoV/England/02/2020, comprises a deletion in a spike cleavage site. The structure and molecular dynamics of this spike provides mechanistic insights into how the deletion modulates virus infectivity
Externí odkaz:
https://doaj.org/article/aca02d9ce50d4ddb8d2a53b3b352d716
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract Aurora kinase B plays an important role in the cell cycle to orchestrate the mitotic process. The amplification and overexpression of this kinase have been implicated in several human malignancies. Therefore, Aurora kinase B is a potential d
Externí odkaz:
https://doaj.org/article/bb75eda4ab704f4381e3015bca49cdde