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Publikováno v:
The Cryosphere, Vol 18, Pp 1733-1751 (2024)
Landscapes buried beneath the Antarctic Ice Sheet preserve information about the geologic and geomorphic evolution of the continent both before and during the wide-scale glaciation that began roughly 34×106 years ago. Since the inception of this ice
Externí odkaz:
https://doaj.org/article/0c277d695b1e44839d5d9efb1b765aef
Autor:
Kade P. Pettie, Maxwell Mumbach, Amanda J. Lea, Julien Ayroles, Howard Y. Chang, Maya Kasowski, Hunter B. Fraser
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract Background Current evidence suggests that cis-regulatory elements controlling gene expression may be the predominant target of natural selection in humans and other species. Detecting selection acting on these elements is critical to underst
Externí odkaz:
https://doaj.org/article/029208ac9127460faeb7e0e1b32c4b4f
Autor:
David S. Kim, José Ángel Moreno-Cabezuelo, Eduardo Nicolas Schulz, David J. Lea-Smith, Uma Shankar Sagaram
Publikováno v:
Frontiers in Climate, Vol 6 (2024)
Atmospheric CO2 removal (CDR) is a fundamentally endergonic process. Performing CDR or Bioenergy with Carbon Capture and Storage (BECCS) at the gigatonne scale will produce a significant additional burden on the planet’s limited renewable energy re
Externí odkaz:
https://doaj.org/article/ad36ff296a1f4d7a97f850736a374e6b
Autor:
Xiao-Yu Zhu, Yang Li, Chun-Xu Xue, Ian D. E. A. Lidbury, Jonathan D. Todd, David J. Lea-Smith, Jiwei Tian, Xiao-Hua Zhang, Jiwen Liu
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-15 (2023)
Abstract Background Hadal trenches (>6000 m) are the deepest oceanic regions on Earth and depocenters for organic materials. However, how these enigmatic microbial ecosystems are fueled is largely unknown, particularly the proportional importance of
Externí odkaz:
https://doaj.org/article/6ee81ed16a0c42f3b662405a7d05e4cf
Publikováno v:
eLife, Vol 12 (2024)
Previously, we showed that a massively parallel reporter assay, mSTARR-seq, could be used to simultaneously test for both enhancer-like activity and DNA methylation-dependent enhancer activity for millions of loci in a single experiment (Lea et al.,
Externí odkaz:
https://doaj.org/article/9db658a652954aa287f21a59463a74d1
Autor:
Lisa R. Moore, Ron Caspi, Douglas A. Campbell, John R. Casey, Sophie Crevecoeur, David J. Lea-Smith, Bin Long, Naaman M. Omar, Suzanne M. Paley, Nicolas M. Schmelling, Alejandro Torrado, Jonathan P. Zehr, Peter D. Karp
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
CyanoCyc is a web portal that integrates an exceptionally rich database collection of information about cyanobacterial genomes with an extensive suite of bioinformatics tools. It was developed to address the needs of the cyanobacterial research and b
Externí odkaz:
https://doaj.org/article/9d9a660bb9a24a14af33a398e0dbb1fb
Autor:
Irene Gallego Romero, Amanda J. Lea
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract A long-standing goal of evolutionary biology is to decode how gene regulation contributes to organismal diversity. Doing so is challenging because it is hard to predict function from non-coding sequence and to perform molecular research with
Externí odkaz:
https://doaj.org/article/fb60b230688642549a49607b2899f220
Autor:
Amanda J Lea, Andrew G Clark, Andrew W Dahl, Orrin Devinsky, Angela R Garcia, Christopher D Golden, Joseph Kamau, Thomas S Kraft, Yvonne A L Lim, Dino J Martins, Donald Mogoi, Päivi Pajukanta, George H Perry, Herman Pontzer, Benjamin C Trumble, Samuel S Urlacher, Vivek V Venkataraman, Ian J Wallace, Michael Gurven, Daniel E Lieberman, Julien F Ayroles
Publikováno v:
PLoS Biology, Vol 21, Iss 9, p e3002311 (2023)
Noncommunicable diseases (NCDs) are on the rise worldwide. Obesity, cardiovascular disease, and type 2 diabetes are among a long list of "lifestyle" diseases that were rare throughout human history but are now common. The evolutionary mismatch hypoth
Externí odkaz:
https://doaj.org/article/2745ad47e80c435daa7ab7fa5ed0c557
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/f9f545a80a81429fa91ce4346a424c48