Zobrazeno 1 - 10
of 26
pro vyhledávání: '"P. J. Klasse"'
Conformational antigenic heterogeneity as a cause of the persistent fraction in HIV-1 neutralization
Autor:
Philippe Colin, Rajesh P. Ringe, Anila Yasmeen, Gabriel Ozorowski, Thomas J. Ketas, Wen-Hsin Lee, Andrew B. Ward, John P. Moore, P. J. Klasse
Publikováno v:
Retrovirology, Vol 20, Iss 1, Pp 1-20 (2023)
Abstract Background Neutralizing antibodies (NAbs) protect against HIV-1 acquisition in animal models and show promise in treatment of infection. They act by binding to the viral envelope glycoprotein (Env), thereby blocking its receptor interactions
Externí odkaz:
https://doaj.org/article/f369c2c702f8496ebac50311e4de718b
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215106 (2019)
We describe methods to improve the efficiency with which HIV-1 Envelope glycoprotein SOSIP trimer immunogens can be produced by transient transfection of ExpiCHO-S cells and then affinity purified using the trimer-specific human monoclonal antibody P
Externí odkaz:
https://doaj.org/article/22f7334a411141ab9e58756e01d438b6
Autor:
Anna-Janina Behrens, Snezana Vasiljevic, Laura K. Pritchard, David J. Harvey, Rajinder S. Andev, Stefanie A. Krumm, Weston B. Struwe, Albert Cupo, Abhinav Kumar, Nicole Zitzmann, Gemma E. Seabright, Holger B. Kramer, Daniel I.R. Spencer, Louise Royle, Jeong Hyun Lee, Per J. Klasse, Dennis R. Burton, Ian A. Wilson, Andrew B. Ward, Rogier W. Sanders, John P. Moore, Katie J. Doores, Max Crispin
Publikováno v:
Cell Reports, Vol 14, Iss 11, Pp 2695-2706 (2016)
The HIV-1 envelope glycoprotein trimer is covered by an array of N-linked glycans that shield it from immune surveillance. The high density of glycans on the trimer surface imposes steric constraints limiting the actions of glycan-processing enzymes,
Externí odkaz:
https://doaj.org/article/e2e8bb16346745dfaa8a226260faf0dc
Autor:
P J Klasse, Thomas J Ketas, Christopher A Cottrell, Gabriel Ozorowski, Gargi Debnath, Diawoye Camara, Erik Francomano, Pavel Pugach, Rajesh P Ringe, Celia C LaBranche, Marit J van Gils, Christine A Bricault, Dan H Barouch, Shane Crotty, Guido Silvestri, Sudhir Kasturi, Bali Pulendran, Ian A Wilson, David C Montefiori, Rogier W Sanders, Andrew B Ward, John P Moore
Publikováno v:
PLoS Pathogens, Vol 14, Iss 2, p e1006913 (2018)
The native-like, soluble SOSIP.664 trimer based on the BG505 clade A env gene of HIV-1 is immunogenic in various animal species, of which the most studied are rabbits and rhesus macaques. The trimer induces autologous neutralizing antibodies (NAbs) c
Externí odkaz:
https://doaj.org/article/62425485d58a4e9caedc9d4b0c68522e
Autor:
Silvia Capucci, Edmund G Wee, Torben Schiffner, Celia C LaBranche, Nicola Borthwick, Albert Cupo, Jonathan Dodd, Hansi Dean, Quentin Sattentau, David Montefiori, Per J Klasse, Rogier W Sanders, John P Moore, Tomáš Hanke
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181886 (2017)
Rabbits and monkeys immunized with HIV type 1 (HIV-1) native-like BG505 SOSIP.664 (BG505s) glycoprotein trimers are known to induce antibodies that can neutralize the autologous tier-2 virus. Here, we assessed the induction of HIV-1 trimer binding an
Externí odkaz:
https://doaj.org/article/96b2207bc5b24d9496ecdec92ae9f12b
Autor:
P. J. Klasse, John P. Moore
Publikováno v:
Journal of Virology. 96
With the much-debated exception of the modestly reduced acquisition reported for the RV144 efficacy trial, HIV-1 vaccines have not protected humans against infection, and a vaccine of similar design to that tested in RV144 was not protective in a lat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b20bd770bb134464642b56466980d2
https://doi.org/10.1128/jvi.00034-22
https://doi.org/10.1128/jvi.00034-22
Autor:
P J Klasse, Celia C LaBranche, Thomas J Ketas, Gabriel Ozorowski, Albert Cupo, Pavel Pugach, Rajesh P Ringe, Michael Golabek, Marit J van Gils, Miklos Guttman, Kelly K Lee, Ian A Wilson, Salvatore T Butera, Andrew B Ward, David C Montefiori, Rogier W Sanders, John P Moore
Publikováno v:
PLoS Pathogens, Vol 12, Iss 9, p e1005864 (2016)
We have investigated the immunogenicity in rabbits of native-like, soluble, recombinant SOSIP.664 trimers based on the env genes of four isolates of human immunodeficiency virus type 1 (HIV-1); specifically BG505 (clade A), B41 (clade B), CZA97 (clad
Externí odkaz:
https://doaj.org/article/79dc137927414ccea029d363f51df72d
Autor:
Rogier W Sanders, Ronald Derking, Albert Cupo, Jean-Philippe Julien, Anila Yasmeen, Natalia de Val, Helen J Kim, Claudia Blattner, Alba Torrents de la Peña, Jacob Korzun, Michael Golabek, Kevin de Los Reyes, Thomas J Ketas, Marit J van Gils, C Richter King, Ian A Wilson, Andrew B Ward, P J Klasse, John P Moore
Publikováno v:
PLoS Pathogens, Vol 9, Iss 9, p e1003618 (2013)
A desirable but as yet unachieved property of a human immunodeficiency virus type 1 (HIV-1) vaccine candidate is the ability to induce broadly neutralizing antibodies (bNAbs). One approach to the problem is to create trimeric mimics of the native env
Externí odkaz:
https://doaj.org/article/3e5c50044db042828a59840116a3f458
Autor:
Athe M N Tsibris, Urboshi Pal, Allison L Schure, Ronald S Veazey, Kevin J Kunstman, Timothy J Henrich, P J Klasse, Steven M Wolinsky, Daniel R Kuritzkes, John P Moore
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28047 (2011)
Maraviroc (MVC) gels are effective at protecting rhesus macaques from vaginal SHIV transmission, but breakthrough infections can occur. To determine the effects of a vaginal MVC gel on infecting SHIV populations in a macaque model, we analyzed plasma
Externí odkaz:
https://doaj.org/article/5283bc49244e401bb6b379778e02330c
Publikováno v:
PLoS Pathogens, Vol 5, Iss 8, p e1000548 (2009)
HIV-1 variants resistant to small molecule CCR5 inhibitors recognize the inhibitor-CCR5 complex, while also interacting with free CCR5. The most common genetic route to resistance involves sequence changes in the gp120 V3 region, a pathway followed w
Externí odkaz:
https://doaj.org/article/b1a325f319c94c629d36884662e67e17