Zobrazeno 1 - 10
of 10
pro vyhledávání: '"P. J. Karnik"'
Publikováno v:
European Journal of Medicinal Chemistry. 31:485-488
Summary Various substituted diphenyl bisamidines were prepared and tested for antiamoebic activity in Golden hamsters and Wistar rats. Compounds 10 showed in vitro activity at 100 μg/mL and displayed excellent in vivo activity against hepatic infect
Publikováno v:
European Journal of Medicinal Chemistry. 30:697-706
Summary Various ethers and thioethers of dihydroartemisinin were prepared by treating dihydroartemisinin with hydroxy alkyl, substituted phenol, hydroxy aralkyl, hydroxy alkynyl and hydroxy heteroalkyl or thiols in the presence of BF3Et2O. The thioet
Publikováno v:
Tetrahedron Letters. 34:6305-6308
Refluxing the propargyl ether 2c with nBu 3 SnH/AIBN in toluene gave the clean single stereoisomer 3 . Similarly the other isomer 2d underwent a smooth radical cyclisation to give 5 . The allyl ether 2e gave 6 , a 1,2-cia 1,5-trans product, under sim
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ChemInform. 22
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ChemInform. 25
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ChemInform. 25
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ChemInform. 27
Summary Various ethers and thioethers of dihydroartemisinin were prepared by treating dihydroartemisinin with hydroxy alkyl, substituted phenol, hydroxy aralkyl, hydroxy alkynyl and hydroxy heteroalkyl or thiols in the presence of BF3Et2O. The thioet
Publikováno v:
ChemInform. 27
Heating the propynyldihydroartemisinin derivatives 4 and 5 with Bu3SnH–AIBN in toluene gave the stereoisomers 18 and 20 (5-exo trig products) respectively. The allyl ether 6 gave 21, a 1,2-cis 1,5-trans product under similar conditions, whereas the
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ChemInform. 21
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ChemInform. 19