Zobrazeno 1 - 10
of 90
pro vyhledávání: '"P. J. Jentsch"'
Autor:
Heng Liu, Maya M. Polovitskaya, Linlin Yang, Meiling Li, Hongyue Li, Zhen Han, Jianguo Wu, Qiansen Zhang, Thomas J. Jentsch, Jun Liao
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112926- (2023)
Summary: Volume-regulated anion channels (VRACs) are hexamers of LRRC8 proteins that are crucial for cell volume regulation. N termini (NTs) of the obligatory LRRC8A subunit modulate VRACs activation and ion selectivity, but the underlying mechanisms
Externí odkaz:
https://doaj.org/article/06096b7a180d4c65b012214fca9c9ff3
Autor:
Shroddha Bose, Cecilia de Heus, Mary E. Kennedy, Fan Wang, Thomas J. Jentsch, Judith Klumperman, Tobias Stauber
Publikováno v:
Biomolecules, Vol 13, Iss 12, p 1799 (2023)
ClC-7 is a ubiquitously expressed voltage-gated Cl−/H+ exchanger that critically contributes to lysosomal ion homeostasis. Together with its β-subunit Ostm1, ClC-7 localizes to lysosomes and to the ruffled border of osteoclasts, where it supports
Externí odkaz:
https://doaj.org/article/b5fbd09b5fc84cbca5cf5b70335ee837
Akademický článek
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Autor:
Hannah Kapell, Luca Fazio, Julia Dyckow, Sophia Schwarz, Andrés Cruz-Herranz, Christina Mayer, Joaquin Campos, Elisa D’Este, Wiebke Möbius, Christian Cordano, Anne-Katrin Pröbstel, Marjan Gharagozloo, Amel Zulji, Venu Narayanan Naik, Anna Delank, Manuela Cerina, Thomas Müntefering, Celia Lerma-Martin, Jana K. Sonner, Jung Hyung Sin, Paul Disse, Nicole Rychlik, Khalida Sabeur, Manideep Chavali, Rajneesh Srivastava, Matthias Heidenreich, Kathryn C. Fitzgerald, Guiscard Seebohm, Christine Stadelmann, Bernhard Hemmer, Michael Platten, Thomas J. Jentsch, Maren Engelhardt, Thomas Budde, Klaus-Armin Nave, Peter A. Calabresi, Manuel A. Friese, Ari J. Green, Claudio Acuna, David H. Rowitch, Sven G. Meuth, Lucas Schirmer
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 7 (2023)
Multiple sclerosis (MS) is a progressive inflammatory demyelinating disease of the CNS. Increasing evidence suggests that vulnerable neurons in MS exhibit fatal metabolic exhaustion over time, a phenomenon hypothesized to be caused by chronic hyperex
Externí odkaz:
https://doaj.org/article/3d8107c041ee41648aa17c5d82d19237
Autor:
Anja Pfau, Karen I. López-Cayuqueo, Nora Scherer, Matthias Wuttke, Annekatrin Wernstedt, Daniela González Fassrainer, Desiree E.C. Smith, Jiddeke M. van de Kamp, Katharina Ziegeler, Kai-Uwe Eckardt, Friedrich C. Luft, Peter S. Aronson, Anna Köttgen, Thomas J. Jentsch, Felix Knauf
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 3 (2023)
Sulfate plays a pivotal role in numerous physiological processes in the human body, including bone and cartilage health. A role of the anion transporter SLC26A1 (Sat1) for sulfate reabsorption in the kidney is supported by the observation of hyposulf
Externí odkaz:
https://doaj.org/article/c70d5d8f3506419b8e69ebb496d32f97
Autor:
Xiaojie Gao, Franziska Bender, Heun Soh, Changwan Chen, Mahsa Altafi, Sebastian Schütze, Matthias Heidenreich, Maria Gorbati, Mihaela-Anca Corbu, Marta Carus-Cadavieco, Tatiana Korotkova, Anastasios V. Tzingounis, Thomas J. Jentsch, Alexey Ponomarenko
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Hippocampal pyramidal cells encode an animal’s location by single action potentials and complex spike bursts. The authors show that Kcnq3-containing M-channels synergistically with GABAergic inputs coordinate complex spike bursts during theta oscil
Externí odkaz:
https://doaj.org/article/f33b14e1f0f7463ca569e8ee7b4956bb
Autor:
Corinna Göppner, Ian J. Orozco, Maja B. Hoegg-Beiler, Audrey H. Soria, Christian A. Hübner, Fabio L. Fernandes-Rosa, Sheerazed Boulkroun, Maria-Christina Zennaro, Thomas J. Jentsch
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Mutations in the chloride channel ClC-2 have been found in primary aldosteronism (PA). Here, Göppner et al. generate transgenic mice expressing a mutant form of ClC-2 that displays increased chloride currents like patient mutations, and find it reca
Externí odkaz:
https://doaj.org/article/84c646bd88094254bc90a68de9c28af6
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Insulin secretion by β-cells is stimulated by glucose and is dependent on the induction of β-cell membrane depolarization, mainly driven by the closure of KATP channels, which in turn promotes voltage-gated Ca2+ channel opening. Here the authors sh
Externí odkaz:
https://doaj.org/article/522fb48cb1dc42bd81e0cdee18ac8bb0
Autor:
Florian Ullrich, Sandy Blin, Katina Lazarow, Tony Daubitz, Jens Peter von Kries, Thomas J Jentsch
Publikováno v:
eLife, Vol 8 (2019)
Acid-sensing ion channels have important functions in physiology and pathology, but the molecular composition of acid-activated chloride channels had remained unclear. We now used a genome-wide siRNA screen to molecularly identify the widely expresse
Externí odkaz:
https://doaj.org/article/b4e93c9d6cbd4a358027e742c7171744
Autor:
Maple N. Chen, Ricardo D. Santander, Elijah J. Talamas, Peter J. Jentsch, Marie-Claude Bon, Srđan G. Aćimović
Publikováno v:
Insects, Vol 12, Iss 5, p 467 (2021)
The samurai wasp, Trissolcus japonicus (Ashmead), has been proposed as a biocontrol agent against brown marmorated stink bugs (BMSB), due to its ability to parasitize and kill BMSB eggs. However, the wasps’ small size makes it challenging for those
Externí odkaz:
https://doaj.org/article/19904f2ababb4e349c20c0f269a4b985