Zobrazeno 1 - 10 of 29 pro vyhledávání: '"P. J. Islip"'
1
Development of a Novel Series of Trialkoxyaryl Derivatives as Specific and Competitive Antagonists of Platelet Activating Factor
Autor: N. J. Cheesman, Demaine Da, M. A. Brockwell, D. A. Sawyer, H. F. Hodson, R. M. Beams, G. J. Blackwell, L.G. Garland, P. J. Islip, R. M. Hyde
Publikováno v: Journal of Medicinal Chemistry. 38:2130-2137
The synthesis and structure-activity relationship (SAR) analysis of a novel series of trialkoxyaryl derivatives, as specific and competitive inhibitors of platelet activating factor (PAF), are described. Molecular modeling comparisons of PAF with the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6085352ac86bddc53256570ae7f34f8b
https://doi.org/10.1021/jm00012a012
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3
The Effects of a Novel Series of Selective Inhibitors of Arachidonate 5-Lipoxygenase on Anaphylactic and Inflammatory Responses
Autor: R. W. Randall, H. F. Hodson, P. J. Islip, P. Bhattacherjee, W. P. Jackson, A. N. Payne, J. A. Salmon, N.K. Boughton-Smith, G. A. Higgs, Salvador Moncada, J. E. Tateson, R.L. Follenfant, Brendan J.R. Whittle, C. H. Reynolds, L.G. Garland
Publikováno v: Annals of the New York Academy of Sciences. 524:307-320
In conclusion, we have described a novel series of acetohydroxamic acids that are potent and selective inhibitors of arachidonate 5-lipoxygenase in vitro and in vivo. In addition, we have shown that these compounds attenuate "leukotriene-dependent" a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291cfbadbca2fcae0911ea03ab588c75
https://doi.org/10.1111/j.1749-6632.1988.tb38554.x
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7
ChemInform Abstract: 5-(Hydroxyimino)-4-methoxy-2-(pivaloylimino)thiazolidine-3-acetamide, a Reduced Nitroheterocyclic Derivative with Potent Schistosomicidal Properties
Autor: M. V. Bogunovic-Batchelor, P. J. Islip
Publikováno v: Chemischer Informationsdienst. 17
The synthesis and antischistosome properties of 5-(hydroxyimino)-4-methoxy-2-(pivaloylimino)thiazolidine-3-acetamide (1) are described. The compound was prepared by reduction of the nitrothiazoline (2) with stannous chloride in methanol, and represen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62294db018eec55008da31228d12f623
https://doi.org/10.1002/chin.198612243
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