Zobrazeno 1 - 10
of 1 008
pro vyhledávání: '"P. J. Howard"'
Autor:
Steven J. Howard, E. Vasseleu, L. Mushahwar, S. Mallawaarachchi, C. Neilsen-Hewett, N. Day, E. C. Melhuish, K. E. Williams
Publikováno v:
BMC Psychology, Vol 12, Iss 1, Pp 1-12 (2024)
Abstract Background Enough is known about self-regulation to establish it as a priority target for education and intervention efforts beginning in early childhood, yet not enough to meaningfully and reliably alter developmental trajectories. Rather t
Externí odkaz:
https://doaj.org/article/9dff32803d574fb3a6af956cdc3eed7b
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract α7 nicotinic acetylcholine receptors (nAChRs) are homopentameric ligand-gated ion channels with critical roles in the nervous system. Recent studies have resolved and functionally annotated closed, open, and desensitized states of these rec
Externí odkaz:
https://doaj.org/article/21ddf1317baa4ea4841d610b8876a006
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract ρ-type γ-aminobutyric acid-A (GABAA) receptors are widely distributed in the retina and brain, and are potential drug targets for the treatment of visual, sleep and cognitive disorders. Endogenous neuroactive steroids including β-estradio
Externí odkaz:
https://doaj.org/article/670fbe13ae4d4d80830997f0f83876d5
Autor:
Xiaolong Gao, Han-I Yeh, Zhengrong Yang, Chen Fan, Fan Jiang, Rebecca J. Howard, Erik Lindahl, John C. Kappes, Tzyh-Chang Hwang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Loss-of-function mutations of the CFTR gene cause the life-shortening genetic disease cystic fibrosis (CF), whereas overactivity of CFTR may lead to secretory diarrhea and polycystic kidney disease. While effective drugs targeting the CFTR p
Externí odkaz:
https://doaj.org/article/86b783d0ca63434bb3730316e05145d3
Autor:
Sanjula D. Singh, Cyprien A. Rivier, Keren Papier, Zeina Chemali, Leidys Gutierrez-Martinez, Livia Parodi, Ernst Mayerhofer, Jasper Senff, Santiago Clocchiatti-Tuozzo, Courtney Nunley, Amy Newhouse, An Ouyang, M. Brandon Westover, Rudolph E. Tanzi, Ronald M. Lazar, Aleksandra Pikula, Sarah Ibrahim, H. Bart Brouwers, Virginia J. Howard, George Howard, Nirupama Yechoor, Thomas Littlejohns, Kevin N. Sheth, Jonathan Rosand, Gregory Fricchione, Christopher D. Anderson, Guido J. Falcone
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/97936073fee1465093218f6396189b30
Autor:
Mike English, Alex Brown, James Marangou, Shobhana Nagraj, Jonathan Carapetis, Bo Remenyi, Karla Canuto, Jeffrey W Cannon, Paul Burgess, Peter Morris, Alex Kaethner, Anna Ralph, Jennifer Yan, Vicki Wade, Daniel Engelman, Andrew Steer, Judith M Katzenellenbogen, Bart J Currie, Benjamin Jones, Gavin Wheaton, David Simon, Holger Unger, Graham Hillis, Natasha J Howard, Joshua R Francis, Emma Haynes, Maida Stewart, Salvador Amaral, Alice Mitchell, Anferida Fernandes Monteiro, Marisa Gilles, Herculano Seixas, Joaquina Maurays, Jade Neave, Chantelle Pears, Meghan Bailey, Maria Tanesi, Helder Neto, Jacqui Williamson, Jessica de Dassel, Simon Slota-Kan
Publikováno v:
BMJ Open, Vol 14, Iss 10 (2024)
Introduction Rheumatic heart disease (RHD) is underdiagnosed globally resulting in missed treatment opportunities and adverse clinical outcomes. We describe the protocol for a study which aims to co-design, implement and conduct an evaluation of a ta
Externí odkaz:
https://doaj.org/article/b4ab7a24c91c41949d475bc71b6d0b21
Autor:
Ying K. Loo, Katherine Wilkinson, Tyler Harkness, George Howard, Virginia J. Howard, Suzanne E. Judd, Neil A. Zakai, Paul Muntner, Lillian Min, Suzanne Oparil, Timothy B. Plante
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 17 (2024)
Background It is unknown how blood pressure (BP) relates to stroke risk across levels of hypertension daily dose (HDD)‐quantified antihypertensive medication intensity. Methods and Results The REGARDS (Reasons for Geographic and Racial Differences
Externí odkaz:
https://doaj.org/article/f39d75960890476093aa45789704a872
Autor:
SM Bollard, J Howard, C Casalou, BS Kelly, K O'Donnell, G Fenn, J O'Reilly, R Milling, M Shields, M Wilson, A Ajaykumar, K Triana, K Wynne, DJ Tobin, PA Kelly, A McCann, SM Potter
Publikováno v:
Translational Oncology, Vol 50, Iss , Pp 102152- (2024)
Background: Plasma-derived Extracellular Vesicles (EVs) have been suggested as novel biomarkers in melanoma, due to their ability to reflect the cell of origin and ease of collection. This study aimed to identify novel EV biomarkers that can discrimi
Externí odkaz:
https://doaj.org/article/9410ced3e557417bba370bd9b46d0392
Autor:
Johanna KS Tiemann, Magdalena Szczuka, Lisa Bouarroudj, Mohamed Oussaren, Steven Garcia, Rebecca J Howard, Lucie Delemotte, Erik Lindahl, Marc Baaden, Kresten Lindorff-Larsen, Matthieu Chavent, Pierre Poulain
Publikováno v:
eLife, Vol 12 (2024)
The rise of open science and the absence of a global dedicated data repository for molecular dynamics (MD) simulations has led to the accumulation of MD files in generalist data repositories, constituting the dark matter of MD — data that is techni
Externí odkaz:
https://doaj.org/article/c3061f03d4e2413684cd2f2b1b6d8754
Autor:
Sanjula D. Singh, Cyprien A. Rivier, Keren Papier, Zeina Chemali, Leidys Gutierrez-Martinez, Livia Parodi, Ernst Mayerhofer, Jasper Senff, Santiago Clocchiatti-Tuozzo, Courtney Nunley, Amy Newhouse, An Ouyang, M. Brandon Westover, Rudolph E. Tanzi, Ronald M. Lazar, Aleksandra Pikula, Sarah Ibrahim, H. Bart Brouwers, Virginia J. Howard, George Howard, Nirupama Yechoor, Thomas Littlejohns, Kevin N. Sheth, Jonathan Rosand, Gregory Fricchione, Christopher D. Anderson, Guido J. Falcone
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
IntroductionThe 21-point Brain Care Score (BCS) is a novel tool designed to motivate individuals and care providers to take action to reduce the risk of stroke and dementia by encouraging lifestyle changes. Given that late-life depression is increasi
Externí odkaz:
https://doaj.org/article/50fe1aa648a74b0a92d860147aa06eab