Zobrazeno 1 - 10
of 130
pro vyhledávání: '"P. J. Hastings"'
Autor:
Yang Yu, Xin Wang, Jordan Fox, Ruofan Yu, Pilendra Thakre, Brenna McCauley, Nicolas Nikoloutsos, Qian Li, P. J. Hastings, Weiwei Dang, Kaifu Chen, Grzegorz Ira
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract In metazoans mitochondrial DNA (mtDNA) or retrotransposon cDNA released to cytoplasm are degraded by nucleases to prevent sterile inflammation. It remains unknown whether degradation of these DNA also prevents nuclear genome instability. We
Externí odkaz:
https://doaj.org/article/7ef9f5d07697495cbae622cab10ae1a7
Autor:
Haowei Du, Angad Jolly, Christopher M. Grochowski, Bo Yuan, Moez Dawood, Shalini N. Jhangiani, He Li, Donna Muzny, Jawid M. Fatih, Zeynep Coban-Akdemir, Mary Esther Carlin, Angela E. Scheuerle, Karin Witzl, Jennifer E. Posey, Matthew Pendleton, Eoghan Harrington, Sissel Juul, P. J. Hastings, Weimin Bi, Richard A. Gibbs, Fritz J. Sedlazeck, James R. Lupski, Claudia M. B. Carvalho, Pengfei Liu
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-21 (2022)
Abstract Background The multiple de novo copy number variant (MdnCNV) phenotype is described by having four or more constitutional de novo CNVs (dnCNVs) arising independently throughout the human genome within one generation. It is a rare peri-zygoti
Externí odkaz:
https://doaj.org/article/fea7d8f692a64a578e2bc6531220b304
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Mechanisms of evolution and evolution of antibiotic resistance are both fundamental and world health problems. Stress-induced mutagenesis defines mechanisms of mutagenesis upregulated by stress responses, which drive adaptation when cells ar
Externí odkaz:
https://doaj.org/article/08449f6d585a4eefad9f76f7706d6fd2
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Understanding factors contributing to variation in ‘biological age’ is essential to understanding variation in susceptibility to disease and functional decline. One factor that could accelerate biological aging in women is reproduction.
Externí odkaz:
https://doaj.org/article/27e4ba3472bb491a91e560cf05395dc0
Autor:
Salisa C. Westrick, Lindsey A. Hohmann, Stuart J. McFarland, Benjamin S. Teeter, Kara K. White, Tessa J. Hastings
Publikováno v:
Papillomavirus Research, Vol 3, Iss , Pp 24-29 (2017)
Purpose: To determine parentsâ knowledge and attitudes regarding human papillomavirus (HPV) vaccinations in their adolescent children and to describe parentsâ perceptions of adolescent vaccinations in community pharmacies. Methods: In-depth intervi
Externí odkaz:
https://doaj.org/article/efc8257b8f01427eb6614fd8e1d6bc7c
Publikováno v:
PLoS Genetics, Vol 13, Iss 7, p e1006733 (2017)
Bacteria, yeast and human cancer cells possess mechanisms of mutagenesis upregulated by stress responses. Stress-inducible mutagenesis potentially accelerates adaptation, and may provide important models for mutagenesis that drives cancers, host path
Externí odkaz:
https://doaj.org/article/a516d49b646c4b2490c53c9594321720
Autor:
Yasir Iqbal, Andreas Kiesel, Moritz Wagner, Christopher Nunn, Olena Kalinina, Astley F. S. J. Hastings, John C. Clifton-Brown, Iris Lewandowski
Publikováno v:
Frontiers in Plant Science, Vol 8 (2017)
Delayed harvest can improve the quality of miscanthus biomass for combustion and enhance the long-term sustainability of the crop, despite accompanying yield losses. The aim of this study is to identify the optimal harvesting time, which can deliver
Externí odkaz:
https://doaj.org/article/6d31eb9a3fe34fb5a09af0b4dabf189f
Autor:
A. Aquila, A. Barty, C. Bostedt, S. Boutet, G. Carini, D. dePonte, P. Drell, S. Doniach, K. H. Downing, T. Earnest, H. Elmlund, V. Elser, M. Gühr, J. Hajdu, J. Hastings, S. P. Hau-Riege, Z. Huang, E. E. Lattman, F. R. N. C. Maia, S. Marchesini, A. Ourmazd, C. Pellegrini, R. Santra, I. Schlichting, C. Schroer, J. C. H. Spence, I. A. Vartanyants, S. Wakatsuki, W. I. Weis, G. J. Williams
Publikováno v:
Structural Dynamics, Vol 2, Iss 4, Pp 041701-041701-13 (2015)
Intense femtosecond x-ray pulses from free-electron laser sources allow the imaging of individual particles in a single shot. Early experiments at the Linac Coherent Light Source (LCLS) have led to rapid progress in the field and, so far, coherent
Externí odkaz:
https://doaj.org/article/f9bc127153034d39b84a7090f09c04d2
Autor:
Heyuan Li, Yin Zhai, Susan M. Rosenberg, John P. Pribis, Jacob Paiano, P. J. Hastings, Jingjing Liu, Devon M. Fitzgerald, Ralf B. Nehring, Jun Xia, Qian Mei, André Nussenzweig
Publikováno v:
Science Advances
Caught in the act, DNA reaction intermediates in bacterial genomes may illuminate disease-driving regions in human chromosomes.
Chromosomal fragile sites are implicated in promoting genome instability, which drives cancers and neurological disea
Chromosomal fragile sites are implicated in promoting genome instability, which drives cancers and neurological disea
Publikováno v:
Current Genetics
Mechanisms of mutation upregulated by stress responses have been described in several organisms from bacteria to human. These mechanisms might accelerate genetic change specifically when cells are maladapted to their environment. Stress-induced mutat