Zobrazeno 1 - 10
of 1 400
pro vyhledávání: '"P. J. Ham"'
Autor:
Nitish Mittal, Meric Ataman, Lionel Tintignac, Daniel J. Ham, Lena Jörin, Alexander Schmidt, Michael Sinnreich, Markus A. Ruegg, Mihaela Zavolan
Publikováno v:
npj Regenerative Medicine, Vol 9, Iss 1, Pp 1-15 (2024)
Abstract Loss of protein homeostasis is one of the hallmarks of aging. As such, interventions that restore proteostasis should slow down the aging process and improve healthspan. Two of the most broadly used anti-aging interventions that are effectiv
Externí odkaz:
https://doaj.org/article/54bd417cb9164c0ba73083549ce6a246
Autor:
Meric Ataman, Nitish Mittal, Lionel Tintignac, Alexander Schmidt, Daniel J. Ham, Asier González, Markus A. Ruegg, Mihaela Zavolan
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Calorie restriction (CR) and treatment with rapamycin (RM), an inhibitor of the mTORC1 growth-promoting signaling pathway, are known to slow aging and promote health from worms to humans. At the transcriptome and proteome levels, long-term C
Externí odkaz:
https://doaj.org/article/1f7ca75d353a4189a55f463594bfe771
Autor:
Marco S. Kaiser, Giulia Milan, Daniel J. Ham, Shuo Lin, Filippo Oliveri, Kathrin Chojnowska, Lionel A. Tintignac, Nitish Mittal, Christian E. Zimmerli, David J. Glass, Mihaela Zavolan, Markus A. Rüegg
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-18 (2022)
Exploring the relationship between mTORC1 and the ubiquitin-proteasome system, light is shed on the paradox between mTORC1-mediated muscle hypertrophy induced by PKB/Akt and the muscle atrophy induced by mTORC1 alone.
Externí odkaz:
https://doaj.org/article/f20a08691add485199dd53a06c8fd523
Autor:
Daniel J. Ham, Anastasiya Börsch, Kathrin Chojnowska, Shuo Lin, Aurel B. Leuchtman, Alexander S. Ham, Marco Thürkauf, Julien Delezie, Regula Furrer, Dominik Burri, Michael Sinnreich, Christoph Handschin, Lionel A. Tintignac, Mihaela Zavolan, Nitish Mittal, Markus A. Rüegg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
The anti-aging intervention calorie restriction (CR) is thought to act via the nutrient-sensing multiprotein complex mTORC1. Here the authors show that the mTORC1-inhibitor rapamycin and CR use largely distinct mechanisms to slow mouse muscle aging.
Externí odkaz:
https://doaj.org/article/444da6d136f045099a95445e8d650a04
Publikováno v:
European Psychiatry, Vol 66, Pp S414-S414 (2023)
Introduction Early neurodevelopmental deviations, such as abnormal cortical folding patterns, are a candidate biomarker for major depressive disorder (MDD). Previous studies on patterns of abnormal cortical gyrification in MDD have provided valuable
Externí odkaz:
https://doaj.org/article/bf16205d28fb453d809a8345cc30228f
Autor:
Anastasiya Börsch, Daniel J. Ham, Nitish Mittal, Lionel A. Tintignac, Eugenia Migliavacca, Jérôme N. Feige, Markus A. Rüegg, Mihaela Zavolan
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Anastasiya Börsch, Daniel Ham, and colleagues generated a time series of phenotypic measurements and RNA-Seq data from mouse skeletal muscle and comparatively analyzed these along comparable rat and human data, to assess the relevance of rodent mode
Externí odkaz:
https://doaj.org/article/2d627932b677454c8644b2aba9b64e4a
Autor:
Daniel J. Ham, Anastasiya Börsch, Shuo Lin, Marco Thürkauf, Martin Weihrauch, Judith R. Reinhard, Julien Delezie, Fabienne Battilana, Xueyong Wang, Marco S. Kaiser, Maitea Guridi, Michael Sinnreich, Mark M. Rich, Nitish Mittal, Lionel A. Tintignac, Christoph Handschin, Mihaela Zavolan, Markus A. Rüegg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
mTORC1 expression is increased during ageing of muscle, and on the other hand, its activation promotes muscle hypertrophy. Here, the authors assess whether mTORC1 has positive or negative effects on ageing, and show that its long-term inhibition pres
Externí odkaz:
https://doaj.org/article/05a591c692df4b149c92e816d5905072
Autor:
Alexander S. Ham, Kathrin Chojnowska, Lionel A. Tintignac, Shuo Lin, Alexander Schmidt, Daniel J. Ham, Michael Sinnreich, Markus A. Rüegg
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 1, Pp 259-273 (2020)
Abstract Background The balance between protein synthesis and degradation (proteostasis) is a determining factor for muscle size and function. Signalling via the mammalian target of rapamycin complex 1 (mTORC1) regulates proteostasis in skeletal musc
Externí odkaz:
https://doaj.org/article/463dbe3786a54576826b6dcaf9675034
Autor:
Daniel J. Ham, Anastasia Gardner, Tahnee L. Kennedy, Jennifer Trieu, Timur Naim, Annabel Chee, Francesca M. Alves, Marissa K. Caldow, Gordon S. Lynch, René Koopman
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract Duchenne muscular dystrophy (DMD) is an X-linked genetic disease characterized by progressive muscle wasting and weakness and premature death. Glucocorticoids (e.g. prednisolone) remain the only drugs with a favorable impact on DMD patients,
Externí odkaz:
https://doaj.org/article/6271200ce1974e419391ebe4bea3de4c
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
The neuromuscular junction (NMJ) is the chemical synapse connecting motor neurons and skeletal muscle fibers. NMJs allow all voluntary movements, and ensure vital functions like breathing. Changes in the structure and function of NMJs are hallmarks o
Externí odkaz:
https://doaj.org/article/475823ef688142baa99220cbc21569ee