Zobrazeno 1 - 10
of 72
pro vyhledávání: '"P. J. Gough"'
Autor:
Jason R Baird, Alejandro F Alice, Roland Saito, Qingqing Chai, Minhua Han, Cindy Ng, Stephanie Han, Beth Fernandez, Sarah Ledoux, Johannes Grosse, Alan J Korman, Megan Potuznik, Venkatesh Rajamanickam, Brady Bernard, Marka R Crittenden, Michael J Gough
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract The uniqueness in each person’s cancer cells and variation in immune infiltrates means that each tumor represents a unique problem, but therapeutic targets can be found among their shared features. Radiation therapy alters the interaction
Externí odkaz:
https://doaj.org/article/cbaeda0ee181438bbb8d05f9ec45b660
Autor:
Gwen Kramer, Tiffany Blair, Shelly Bambina, Aanchal Preet Kaur, Alejandro Alice, Jason Baird, David Friedman, Alexa K. Dowdell, Michio Tomura, Clemens Grassberger, Brian D. Piening, Marka R. Crittenden, Michael J. Gough
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract T cells recirculate through tissues and lymphatic organs to scan for their cognate antigen. Radiation therapy provides site-specific cytotoxicity to kill cancer cells but also has the potential to eliminate the tumor-specific T cells in fiel
Externí odkaz:
https://doaj.org/article/921a05abf75b46bca345c3b931ab641e
Autor:
Laura Naidenov, Chris Grindle, Jonathon Duke, Elena J. Gough, Nick Davis, Dave Hall, James O. Waterman, Lisa Holmes
Publikováno v:
Frontiers in Conservation Science, Vol 5 (2024)
The modern zoo relies on the persistence of genetically and physiologically healthy populations of endangered species, which is enabled through breeding programmes globally and regionally. Many species commonly held in zoos are poorly studied in the
Externí odkaz:
https://doaj.org/article/f4b2c97261cd4fe3a2021592c3dbb9c6
Autor:
Terry R. Medler, Tiffany C. Blair, Alejandro F. Alice, Alexa K. Dowdell, Brian D. Piening, Marka R. Crittenden, Michael J. Gough
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Radiation therapy induces immunogenic cell death in cancer cells, whereby released endogenous adjuvants are sensed by immune cells to direct adaptive immune responses. TLRs expressed on several immune subtypes recognize innate adjuvants to d
Externí odkaz:
https://doaj.org/article/749dcd8729de41a6a451e3c2da813f94
Autor:
Jasmine Chen, Aleks C. Guanizo, W. Samantha N. Jakasekara, Chaitanya Inampudi, Quinton Luong, Daniel J. Garama, Muhammad Alamgeer, Nishant Thakur, Michael DeVeer, Vinod Ganju, D. Neil Watkins, Jason E. Cain, Daniel J. Gough
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-14 (2023)
Abstract Background Small cell lung cancer (SCLC) is an aggressive neuroendocrine cancer with an appalling overall survival of less than 5% (Zimmerman et al. J Thor Oncol 14:768-83, 2019). Patients typically respond to front line platinum-based doubl
Externí odkaz:
https://doaj.org/article/188977388363466f976932deaf19e20a
Autor:
Terry R. Medler, Gwen Kramer, Shelly Bambina, Andrew J. Gunderson, Alejandro Alice, Tiffany Blair, Lauren Zebertavage, Thomas Duhen, Rebekka Duhen, Kristina Young, Marka R. Crittenden, Michael J. Gough
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Tissue resident memory (Trm) CD8 T cells infiltrating tumors represent an enriched population of tumor antigen-specific T cells, and their presence is associated with improved outcomes in patients. Using genetically engineered mouse pancreat
Externí odkaz:
https://doaj.org/article/71fc1c1f57f6476d9ed4a952100a3793
Autor:
David Friedman, Marka Crittenden, Michael J Gough, Jason Baird, Alejandro Alice, Megan Ball, Gwen Kramer, Aanchal Preet Kaur
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/a133744d121d434481d281930d5422ce
Autor:
C. Dilanka Fernando, W. Samantha N. Jayasekara, Chaitanya Inampudi, Maija R.J. Kohonen-Corish, Wendy A. Cooper, Traude H. Beilharz, Tracy M. Josephs, Daniel J. Garama, Daniel J. Gough
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113033- (2023)
Summary: Signal transducer and activator of transcription 3 (STAT3) is a potent transcription factor necessary for life whose activity is corrupted in diverse diseases, including cancer. STAT3 biology was presumed to be entirely dependent on its acti
Externí odkaz:
https://doaj.org/article/0b416294b8d648a2b18c0473e3703a04
Publikováno v:
Frontiers in Oral Health, Vol 4 (2023)
Although treatment modalities for head and neck cancer have evolved considerably over the past decades, survival rates have plateaued. The treatment options remained limited to definitive surgery, surgery followed by fractionated radiotherapy with op
Externí odkaz:
https://doaj.org/article/d34d305cbb4540a9a0d69c31093fa36d
Autor:
Tiffany Blair, Jason Baird, Shelly Bambina, Gwen Kramer, Monica Gostissa, Christopher J. Harvey, Michael J. Gough, Marka R. Crittenden
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Multiple preclinical studies have shown improved outcomes when radiation therapy is combined with immune modulating antibodies. However, to date, many of these promising results have failed to translate to successful clinical studies. This l
Externí odkaz:
https://doaj.org/article/21ac5561946c41e388a9df3b45107e2b