Zobrazeno 1 - 10
of 27
pro vyhledávání: '"P. J. Gearhart"'
Publikováno v:
Immunity & Ageing, Vol 19, Iss 1, Pp 1-16 (2022)
Abstract The sequestering of oxidation-modified low-density lipoprotein by macrophages results in the accumulation of fatty deposits within the walls of arteries. Necrosis of these cells causes a release of intercellular epitopes and the activation o
Externí odkaz:
https://doaj.org/article/2817a44b255949d38e988ab5d19ab25a
Autor:
Ophélie A. Martin, Morgane Thomas, Marie Marquet, Charlotte Bruzeau, Armand Garot, Mylène Brousse, Sébastien Bender, Claire Carrion, Jee Eun Choi, Bao Q. Vuong, Patricia J. Gearhart, Robert W. Maul, Sandrine Le Noir, Eric Pinaud
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntoductionTwo scaffold/matrix attachment regions (5’- and 3’-MARsEµ) flank the intronic core enhancer (cEµ) within the immunoglobulin heavy chain locus (IgH). Besides their conservation in mice and humans, the physiological role of MARsEµ is
Externí odkaz:
https://doaj.org/article/1ce217207e1e471da5b5f04499b868f6
Autor:
Rebecca L. Ursin, Santosh Dhakal, Hsuan Liu, Sahana Jayaraman, Han-Sol Park, Harrison R. Powell, Morgan L. Sherer, Kirsten E. Littlefield, Ashley L. Fink, Zexu Ma, Alice L. Mueller, Allison P. Chen, Kumba Seddu, Yishak A. Woldetsadik, Patricia J. Gearhart, H. Benjamin Larman, Robert W. Maul, Andrew Pekosz, Sabra L. Klein
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Inactivated influenza vaccines induce greater antibody responses in females than males among both humans and mice. To test the breadth of protection, we used recombinant mouse-adapted A/California/2009 (maA/Cal/09) H1N1 viruses containing mu
Externí odkaz:
https://doaj.org/article/27b9d2f8ed4943bdbee66b3ea7cdb0de
Autor:
Mark A. Hutchinson, Han-Sol Park, Kimberly J. Zanotti, Juan Alvarez-Gonzalez, Jing Zhang, Li Zhang, Richard Telljohann, Mingyi Wang, Edward G. Lakatta, Patricia J. Gearhart, Robert W. Maul
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Current models stipulate that B cells and antibodies function during atherosclerosis in two distinct ways based on antibody isotype, where IgM is protective and IgG is inflammatory. To examine this model, we generated ApoE-/- Aid-/- mice, which are u
Externí odkaz:
https://doaj.org/article/bb200d6a373c44d08ca54786ef48d485
Autor:
Robert W. Maul, Michelle D. Catalina, Varsha Kumar, Prathyusha Bachali, Amrie C. Grammer, Shu Wang, William Yang, Sarfaraz Hasni, Rachel Ettinger, Peter E. Lipsky, Patricia J. Gearhart
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
A distinct B cell population marked by elevated CD11c expression is found in patients with systemic lupus erythematosus (SLE). Cells with a similar phenotype have been described during chronic infection, but variable gating strategies and nomenclatur
Externí odkaz:
https://doaj.org/article/707613ee2f574cff9115f1812bfc2934
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The goal of immunization is to produce both a flood of antibodies to neutralize antigen and memory cells to accelerate the secondary response. To enhance the generation of memory B cells, we examined the effect of co-engaging BCR and toll-like recept
Externí odkaz:
https://doaj.org/article/a375feb5dd224c028929d6d58ee48b55
Publikováno v:
PLoS Biology, Vol 13, Iss 12, p e1002321 (2015)
Antibodies stand between us and pathogens. Viruses mutate quickly to avoid detection, and antibodies mutate at similar rates to hunt them down. This death spiral is fueled by specialized proteins and error-prone polymerases that change DNA sequences.
Externí odkaz:
https://doaj.org/article/245ed6e90c41412a9f6daf1a9ded73c4
Autor:
P. J. Gearhart, Richard D. Wood, I. Rosewell, Gordon Stamp, M. A. Jacobs, El-Nasir Lalani, Mahmud K.K. Shivji, Federica Marini, J. Wittschieben
Publikováno v:
Current Biology. 10(19):1217-1220
The REV3 gene encodes the catalytic subunit of DNA polymerase (pol) zeta, which can replicate past certain types of DNA lesions [1]. Saccharomyces cerevisiae rev3 mutants are viable and have lower rates of spontaneous and DNA-damage-induced mutagenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d44a43f4421343bb82b3f14e0e41f0e8
Publikováno v:
Journal of clinical immunology. 21(2)
Chronological aging is associated with an accumulation of DNA mutations that results in cancer formation. The effect of aging on spontaneous mutations in humans is difficult to study because mutations are infrequent in the overall genome and tumors a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4d9ae6e242a2b6fdcde838da9f7706e2
https://pubmed.ncbi.nlm.nih.gov/11332649
https://pubmed.ncbi.nlm.nih.gov/11332649
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(6)
During somatic hypermutation of Ig V genes, mismatched nucleotide substitutions become candidates for removal by the DNA mismatch repair pathway. Previous studies have shown that V genes from mice deficient for the MSH2 and PMS2 mismatch repair prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da7f7a9d5f3c99e7321205be5c32f9cb
https://pubmed.ncbi.nlm.nih.gov/10092760
https://pubmed.ncbi.nlm.nih.gov/10092760