Zobrazeno 1 - 10
of 61
pro vyhledávání: '"P. J. Frazier"'
Publikováno v:
Frontiers in Drug Discovery, Vol 4 (2024)
The development of medical countermeasures (MCMs) against organophosphate (OP) induced poisoning is of substantial importance. Use of conventional therapeutics is complicated by off-target effects and restricted penetration of the blood-brain barrier
Externí odkaz:
https://doaj.org/article/8c8e9dc495bb4ac88a2e30d724a954f5
Publikováno v:
Royal Society Open Science, Vol 11, Iss 6 (2024)
Host–microbiota interactions play a critical role in the hosts’ biology, and thus, it is crucial to elucidate the mechanisms that shape gut microbial communities. We leveraged threespine stickleback fish (Gasterosteus aculeatus) as a model system
Externí odkaz:
https://doaj.org/article/3d5fad11cadb4161a76071d5aae1a3b5
Autor:
Jeffrey S. Thinschmidt, Scott W. Harden, Michael A. King, James D. Talton, Charles J. Frazier
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
We established a novel brain slice assay to test the ability of acetylcholinesterase (AChE) reactivators to prevent ACh-induced M1 muscarinic acetylcholine receptor (mAChR) dependent hyperexcitability observed after exposure to the organophosphate (O
Externí odkaz:
https://doaj.org/article/3545c7d60f87475388b0638bb2d7565a
Autor:
Khalid Elsaafien, Scott W. Harden, Dominique N. Johnson, Aecha K. Kimball, Wanhui Sheng, Justin A. Smith, Karen A. Scott, Charles J. Frazier, Annette D. de Kloet, Eric G. Krause
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The brain maintains cardiovascular homeostasis, in part, via the arterial baroreflex which senses changes in blood pressure (BP) at the level of the aortic arch. Sensory afferents innervating the aortic arch employ baroreceptors to convert stretch ex
Externí odkaz:
https://doaj.org/article/0d05e03e04494f7ea60e27dbb7215a69
Autor:
Yuning Liu, Hong Xing, Wanhui Sheng, Kyle N. Singh, Alexandra G. Korkmaz, Caroline Comeau, Maisha Anika, Alexis Ernst, Fumiaki Yokoi, David E. Vaillancourt, Charles J. Frazier, Yuqing Li
Publikováno v:
Neurobiology of Disease, Vol 154, Iss , Pp 105342- (2021)
Dystonia is a neurological movement disorder characterized by sustained or intermittent muscle contractions, repetitive movement, and sometimes abnormal postures. DYT1 dystonia is one of the most common genetic dystonias, and most patients carry hete
Externí odkaz:
https://doaj.org/article/8236ce4e236641d7869644a27c28edb8
Publikováno v:
eLife, Vol 10 (2021)
Hypothalamic oxytocinergic magnocellular neurons have a fascinating ability to release peptide from both their axon terminals and from their dendrites. Existing data indicates that the relationship between somatic activity and dendritic release is no
Externí odkaz:
https://doaj.org/article/19dfdf9a26634505adf3a81dff24a0a3
Autor:
Caesar M Hernandez, Caitlin A Orsini, Chase C Labiste, Alexa-Rae Wheeler, Tyler W Ten Eyck, Matthew M Bruner, Todd J Sahagian, Scott W Harden, Charles J Frazier, Barry Setlow, Jennifer L Bizon
Publikováno v:
eLife, Vol 8 (2019)
Across species, aging is associated with an increased ability to choose delayed over immediate gratification. These experiments used young and aged rats to test the role of the basolateral amygdala (BLA) in intertemporal decision making. An optogenet
Externí odkaz:
https://doaj.org/article/69ee7725cacd4768938b686075c7c79c
Autor:
Tomáš Krejčí, Josef Navrátil, Stanislav Martinát, Ryan J. Frazier, Petr Klusáček, Kamil Pícha, Jaroslav Škrabal, Robert Osman
Publikováno v:
Land, Vol 10, Iss 3, p 325 (2021)
The fall of the Iron Curtain created a vacuum upon which large-scale collectivized agriculture was largely abandoned. Post-agricultural brownfields emerge in multiple manners across national, regional and local levels. While these sites remain rarely
Externí odkaz:
https://doaj.org/article/0dfa4715ae6b42868b4c08ef263a4783
Non-Reciprocal Supratransmission in Mechanical Lattices with Non-Local Feedback Control Interactions
Autor:
Jack E. Pechac, Michael J. Frazier
Publikováno v:
Crystals, Vol 11, Iss 2, p 94 (2021)
We numerically investigate the supratransmission phenomenon in an active nonlinear system modeled by the 1D/2D discrete sine-Gordon equation with non-local feedback. While, at a given frequency, the typical passive system exhibits a single amplitude
Externí odkaz:
https://doaj.org/article/ad82ed9262064be8933adb9262c956ad
Publikováno v:
Land, Vol 9, Iss 12, p 533 (2020)
The near elimination of inland salt marshes in Central Europe occurred throughout the 19th and 20th centuries, and the currently remaining marshes exist in a degraded condition. This work examines the impact of groundwater level on the growth of plan
Externí odkaz:
https://doaj.org/article/b946f797a7bb4b8384b3c0f13c27b41a