Zobrazeno 1 - 10
of 18
pro vyhledávání: '"P. J. Fadel"'
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Autonomic adjustments of the cardiovascular system are critical for initiating and sustaining exercise by facilitating the redistribution of blood flow and oxygen delivery to meet the metabolic demands of the active skeletal muscle. Afferent feedback
Externí odkaz:
https://doaj.org/article/dee9188aa5d649179ec33857b3a136e1
Autor:
Allison Ballandras-Colas, Vidya Chivukula, Dominika T. Gruszka, Zelin Shan, Parmit K. Singh, Valerie E. Pye, Rebecca K. McLean, Gregory J. Bedwell, Wen Li, Andrea Nans, Nicola J. Cook, Hind J. Fadel, Eric M. Poeschla, David J. Griffiths, Javier Vargas, Ian A. Taylor, Dmitry Lyumkis, Hasan Yardimci, Alan N. Engelman, Peter Cherepanov
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The authors determined high-resolution cryo-EM structures of the lentiviral intasome — the nucleoprotein complex that inserts viral DNA into a host chromosome — and show that the architecture comprising 16 integrase subunits is critical for its f
Externí odkaz:
https://doaj.org/article/38b768c566d24b6c8e369c087cb41667
Autor:
Parmit Kumar Singh, Wen Li, Gregory J. Bedwell, Hind J. Fadel, Eric M. Poeschla, Alan N. Engelman
Publikováno v:
Viruses, Vol 14, Iss 9, p 1883 (2022)
Allosteric integrase (IN) inhibitors (ALLINIs), which are promising preclinical compounds that engage the lens epithelium-derived growth factor (LEDGF)/p75 binding site on IN, can inhibit different aspects of human immunodeficiency virus 1 (HIV-1) re
Externí odkaz:
https://doaj.org/article/7577eca5ddbd4533ae9c76d4eb51dcf4
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Emerging evidence suggests that type 2 diabetes (T2D) may impair the ability to properly adjust the circulation during exercise with augmented blood pressure (BP) and an attenuated contracting skeletal muscle blood flow (BF) response being reported.
Externí odkaz:
https://doaj.org/article/a6b86e6969de479984b00afae2743d75
Akademický článek
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Autor:
Wen Li, Parmit K. Singh, Gregory A. Sowd, Gregory J. Bedwell, Sooin Jang, Vasudevan Achuthan, Amarachi V. Oleru, Doris Wong, Hind J. Fadel, KyeongEun Lee, Vineet N. KewalRamani, Eric M. Poeschla, Alon Herschhorn, Alan N. Engelman
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT Lentiviral DNA integration favors transcriptionally active chromatin. We previously showed that the interaction of human immunodeficiency virus type 1 (HIV-1) capsid with cleavage and polyadenylation specificity factor 6 (CPSF6) localizes vi
Externí odkaz:
https://doaj.org/article/7f4eaeb2c24147479988497d78e83da7
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Twenty-three young adults (4 Females, 25.13 ± 3.72 years) performed an intermittent maximal handgrip force task using their dominant hand for 20 min (3.5 s squeeze/6.5 s release, 120 blocks) with concurrent cortical activity imaging by functional Ne
Externí odkaz:
https://doaj.org/article/e0bbdde79f2b4814a0aed665fd4461b9
Autor:
Kanokwan Bunsawat, Georgios Grigoriadis, Elizabeth C. Schroeder, Alexander J. Rosenberg, Melissa M. Rader, Paul J. Fadel, Philip S. Clifford, Bo Fernhall, Tracy Baynard
Publikováno v:
Physiological Reports, Vol 7, Iss 8, Pp n/a-n/a (2019)
Abstract Sympathetic vasoconstriction is attenuated in exercising muscles to assist in matching of blood flow with metabolic demand. This “functional sympatholysis” may be impaired in young obese individuals due to greater sympathetic activation
Externí odkaz:
https://doaj.org/article/d0ad1612a3fb4e81a7c6828c8f4959ca
Autor:
Daniel C. DeSimone, Philip R. Heaton, Brian A. Neff, Linda N. Dao, Nancy L. Wengenack, Hind J. Fadel
Publikováno v:
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, Vol 8, Iss , Pp 13-15 (2017)
Chronic otitis externa due to Mycobacterium tuberculosis complex is extremely rare and very few cases have been presented in the medical literature. We report here the case of an immunocompetent 68-year-old male with chronic auricular drainage, otalg
Externí odkaz:
https://doaj.org/article/fa87b4fc72e142e4bdeb35e8619b6c76
Autor:
Jennifer M Reiman, Biswadeep Das, Gregory M Sindberg, Mark D Urban, Madeleine E M Hammerlund, Han B Lee, Katie M Spring, Jamie Lyman-Gingerich, Alex R Generous, Tyler H Koep, Kevin Ewing, Phil Lilja, Felicity T Enders, Stephen C Ekker, W Charles Huskins, Hind J Fadel, Chris Pierret
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204337 (2018)
Influenza is a global problem infecting 5-10% of adults and 20-30% of children annually. Non-pharmaceutical interventions (NPIs) are attractive approaches to complement vaccination in the prevention and reduction of influenza. Strong cyclical reducti
Externí odkaz:
https://doaj.org/article/9f84f6e74b434b55be8f7fe473de5bc2