Zobrazeno 1 - 10
of 79
pro vyhledávání: '"P. J. Durham"'
Autor:
Paula A. Bender, Subhajit Chakraborty, Ryan J. Durham, Vladimir Berka, Elisa Carrillo, Vasanthi Jayaraman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract N-methyl-D-aspartate (NMDA) receptors are ionotropic glutamate receptors involved in learning and memory. NMDA receptors primarily comprise two GluN1 and two GluN2 subunits. The GluN2 subunit dictates biophysical receptor properties, includi
Externí odkaz:
https://doaj.org/article/c7173c3d6f4e45779018b879e76e596c
Autor:
Xiaolong Gao, Philipp A. M. Schmidpeter, Vladimir Berka, Ryan J. Durham, Chen Fan, Vasanthi Jayaraman, Crina M. Nimigean
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Visualizing conformational changes during ion channel gating is crucial to understand their regulation. Here, Gao et al. capture multiple gating intermediates in a CNG channel as well as subtle, lateral voltage sensor movements necessary for channel
Externí odkaz:
https://doaj.org/article/af4d9d2c2bc148cca9a11f009df54393
Autor:
Kristen A. McGovern, William J. Durham, Traver J. Wright, E. Lichar Dillon, Kathleen M. Randolph, Christopher P. Danesi, Randall J. Urban, Melinda Sheffield-Moore
Publikováno v:
Current Oncology, Vol 29, Iss 11, Pp 8340-8356 (2022)
Many cancer patients undergoing treatment experience cancer-related fatigue (CRF). Inflammatory markers are correlated with CRF but are not routinely targeted for treatment. We previously demonstrated in an NIH-funded placebo-controlled, double-blind
Externí odkaz:
https://doaj.org/article/a04fd1d4dabd4c27b968e0e1078a1c2a
Autor:
Robert S Rogers, Hong Wang, Timothy J Durham, Jonathan A Stefely, Norah A Owiti, Andrew L Markhard, Lev Sandler, Tsz-Leung To, Vamsi K Mootha
Publikováno v:
PLoS Biology, Vol 21, Iss 5, p e3002117 (2023)
There is widespread interest in identifying interventions that extend healthy lifespan. Chronic continuous hypoxia delays the onset of replicative senescence in cultured cells and extends lifespan in yeast, nematodes, and fruit flies. Here, we asked
Externí odkaz:
https://doaj.org/article/56d5adc8ffd44d2ca1e52f0708949c87
Autor:
Angelica Del Rosario, Kathleen Feng, Lena Haddad, Brian Lee, Ryan Murakami, Eric Pinashin, Ashley Tuttle, Kevin Young, Melissa J. Durham, Edith Mirzain
Publikováno v:
Journal of Contemporary Pharmacy Practice, Vol 67, Iss 2, Pp 33-38 (2020)
Externí odkaz:
https://doaj.org/article/fede068ceb9a448ea97633b49abc49af
Autor:
Rabia Asghar, Maria Chondronikola, Edgar L. Dillon, William J. Durham, Craig Porter, Zhanpin Wu, Maria Camacho-Hughes, Clark R. Andersen, Heidi Spratt, Elena Volpi, Melinda Sheffield-Moore, Labros Sidossis, Robert R. Wolfe, Nicola Abate, Demidmaa R. Tuvdendorj
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 10, Pp 2018-2024 (2018)
Intramyocellular triglyceride (imTG) in skeletal muscle plays a significant role in metabolic health, and an infusion of [13C16]palmitate can be used to quantitate the in vivo fractional synthesis rate (FSR) and absolute synthesis rate (ASR) of imTGs
Externí odkaz:
https://doaj.org/article/2188cfb633d8429ca24770a74a2bcf79
Autor:
Traver J. Wright, E. Lichar Dillon, William J. Durham, Albert Chamberlain, Kathleen M. Randolph, Christopher Danesi, Astrid M. Horstman, Charles R. Gilkison, Maurice Willis, Gwyn Richardson, Sandra S. Hatch, Daniel C. Jupiter, Susan McCammon, Randall J. Urban, Melinda Sheffield‐Moore
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 3, Pp 482-496 (2018)
Abstract Background Cancer cachexia negatively impacts cancer‐related treatment options, quality of life, morbidity, and mortality, yet no established therapies exist. We investigated the anabolic properties of testosterone to limit the loss of bod
Externí odkaz:
https://doaj.org/article/eca7ed97f9ef494c810546b580b0966d
Autor:
Timothy J. Durham, Maxwell W. Libbrecht, J. Jeffry Howbert, Jeff Bilmes, William Stafford Noble
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Assays to characterize the epigenome and interrogate chromatin state genome wide have so far been performed in a selected set of conditions. Here, Durham et al. develop a computational method based on tensor decomposition to impute missing experiment
Externí odkaz:
https://doaj.org/article/7efe8cda7bfd4c9eb9281adc0e0e8c68
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 187-207 (2018)
Modeling interactions between primary human hepatocytes (PHHs) and primary human liver sinusoidal endothelial cells (LSECs) in vitro can help elucidate human-specific mechanisms underlying liver physiology/disease and drug responses; however, existin
Externí odkaz:
https://doaj.org/article/96fde98f579a4ae780eadd6fbbee0bdc
Autor:
E Lichar Dillon, Kizhake V Soman, John E Wiktorowicz, Ria Sur, Daniel Jupiter, Christopher P Danesi, Kathleen M Randolph, Charles R Gilkison, William J Durham, Randall J Urban, Melinda Sheffield-Moore
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0217690 (2019)
IntroductionLong-term head-down bed rest (HDBR) results in musculoskeletal losses similar to those observed during long-term space flight. Agents such as testosterone, in addition to regular exercise, are effective countermeasures for reducing loss o
Externí odkaz:
https://doaj.org/article/3bea696f78884a82b6ad7d6dc854c8c3