Zobrazeno 1 - 10
of 12
pro vyhledávání: '"P. J. Desmet"'
Autor:
Sofie J. Desmet, Jonathan Thommis, Tineke Vanderhaeghen, Edmee M.F. Vandenboorn, Dorien Clarisse, Yunkun Li, Steven Timmermans, Daria Fijalkowska, Dariusz Ratman, Evelien Van Hamme, Lode De Cauwer, Bart Staels, Luc Brunsveld, Frank Peelman, Claude Libert, Jan Tavernier, Karolien De Bosscher
Publikováno v:
Molecular Metabolism, Vol 84, Iss , Pp 101938- (2024)
Objective: The peroxisome proliferator-activated receptor α (PPARα) is a transcription factor driving target genes involved in fatty acid β-oxidation. To what extent various PPARα interacting proteins may assist its function as a transcription fa
Externí odkaz:
https://doaj.org/article/1e23832839bc4f67a6376a644117993b
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/700654afe1cc4bbf84a6aa48103f20b9
Autor:
Francesca Rapino, Zhaoli Zhou, Ana Maria Roncero Sanchez, Marc Joiret, Christian Seca, Najla El Hachem, Gianluca Valenti, Sara Latini, Kateryna Shostak, Liesbet Geris, Ping Li, Gang Huang, Gabriel Mazzucchelli, Dominique Baiwir, Christophe J. Desmet, Alain Chariot, Michel Georges, Pierre Close
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Wobble uridine (U34) tRNA modifications are important for the decoding of AA-ending codons. Here the authors show that while the U34-codon content of mRNAs are predictive of changes in ribosome translation elongation, the resulting outcome in protein
Externí odkaz:
https://doaj.org/article/c065fd32e605402394e0d38dfe8266a8
Autor:
Aline Fastrès, Dimitri Pirottin, Laurence Fievez, Alexandru-Cosmin Tutunaru, Géraldine Bolen, Anne-Christine Merveille, Thomas Marichal, Christophe J. Desmet, Fabrice Bureau, Cécile Clercx
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Canine idiopathic pulmonary fibrosis (CIPF) affects old dogs from the West Highland white terrier (WHWT) breed and mimics idiopathic pulmonary fibrosis (IPF) in human. The disease results from deposition of fibrotic tissue in the lung parenchyma caus
Externí odkaz:
https://doaj.org/article/d78c612ddb1d4d26909284d85c464a74
Autor:
Aline Fastrès, Dimitri Pirottin, Laurence Fievez, Thomas Marichal, Christophe J. Desmet, Fabrice Bureau, Cécile Clercx
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Single-cell mRNA-sequencing (scRNA-seq) is a technique which enables unbiased, high throughput and high-resolution transcriptomic analysis of the heterogeneity of cells within a population. This recent technique has been described in humans, mice and
Externí odkaz:
https://doaj.org/article/a1b79d750d354b52b04de4b05267ec52
Autor:
Francesco Callea, Isabella Giovannoni, Paola Francalanci, Renata Boldrini, Gavino Faa, Daniela Medicina, Valerio Nobili, Valeer J. Desmet, Kamal Ishak, Kuniaki Seyama, Emanuele Bellacchio
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 13, Iss 1, Pp 1-9 (2018)
Abstract Background Alpha-1-antitrypsin (AAT) deficiency (AATD) of Z, Mmalton, Siiyama type is associated with liver storage of the mutant proteins and liver disease. The Z variant can be diagnosed on isoelectric focusing (IEF) while Mmalton and Siiy
Externí odkaz:
https://doaj.org/article/6edc85286bc744ac968de75982c1f32e
Autor:
S. J. Desmet, N. Bougarne, L. Van Moortel, L. De Cauwer, J. Thommis, M. Vuylsteke, D. Ratman, R. Houtman, J. Tavernier, K. De Bosscher
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The glucocorticoid receptor (GR) is a transcription factor of which the underlying gene regulatory mechanisms are complex and incompletely understood. The non-steroidal anti-inflammatory Compound A (CpdA), a selective GR modulating compound
Externí odkaz:
https://doaj.org/article/ae5e8eb524af4a239064508dc35c8b0a
Autor:
Khalil Farhat, Gwennaëlle Bodart, Chantal Charlet-Renard, Christophe J. Desmet, Michel Moutschen, Yves Beguin, Frédéric Baron, Pierrette Melin, Pascale Quatresooz, Anne-Simone Parent, Daniel Desmecht, Jean-Claude Sirard, Roberto Salvatori, Henri Martens, Vincent G. Geenen
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The precise impact of the somatotrope axis upon the immune system is still highly debated. We have previously shown that mice with generalized ablation of growth hormone (GH) releasing hormone (GHRH) gene (Ghrh−/−) have normal thymus and T-cell d
Externí odkaz:
https://doaj.org/article/22a608eee038493ab976b36623155722
Autor:
Stefania Crotta, Sophia Davidson, Tanel Mahlakoiv, Christophe J Desmet, Matthew R Buckwalter, Matthew L Albert, Peter Staeheli, Andreas Wack
Publikováno v:
PLoS Pathogens, Vol 9, Iss 11, p e1003773 (2013)
Interferons (IFNs) are a group of cytokines with a well-established antiviral function. They can be induced by viral infection, are secreted and bind to specific receptors on the same or neighbouring cells to activate the expression of hundreds of IF
Externí odkaz:
https://doaj.org/article/2d13d9968cc0490f91296ce8bbee72a2
Autor:
Claire Mesnil, Catherine M Sabatel, Thomas Marichal, Marie Toussaint, Didier Cataldo, Pierre-Vincent Drion, Pierre Lekeux, Fabrice Bureau, Christophe J Desmet
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e53242 (2012)
Conventional dendritic cells (DCs) are considered to be the prime initiators of airway allergy. Yet, it remains unclear whether specific DC subsets are preferentially involved in allergic airway sensitization. Here, we systematically assessed the res
Externí odkaz:
https://doaj.org/article/eb2528345be54e6783a60b74a69aec96