Zobrazeno 1 - 10
of 74
pro vyhledávání: '"P. J. Creaven"'
Autor:
L, Pendyala, G, Schwartz, W, Bolanowska-Higdon, S, Hitt, J, Zdanowicz, M, Murphy, D, Lawrence, P J, Creaven
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 10(3)
An N-acetylcysteine (NAC)/oltipraz (OLZ) combination was studied in healthy volunteer smokers who received daily NAC (1200 mg/day) and were randomized to weekly placebo (Arm A), OLZ 200 mg (Arm B), or 400 mg (Arm C). Treatment was for 12 weeks with f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c0c467399605c3c0cd48c1db51015842
https://pubmed.ncbi.nlm.nih.gov/11303598
https://pubmed.ncbi.nlm.nih.gov/11303598
Publikováno v:
Cancer investigation. 17(1)
Diarrhea is dose-limiting with weekly 5-fluorouracil (5-FU) plus high-dose leucovorin (LV). Granulocyte-macrophage colony-stimulating factor (GM-CSF) has been associated with a decrease in chemotherapy-associated mucosal toxicity. This study was cond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a396da245b4443f689de2cda7d81bb42
https://pubmed.ncbi.nlm.nih.gov/10999043
https://pubmed.ncbi.nlm.nih.gov/10999043
Autor:
L, Pendyala, P J, Creaven, G, Schwartz, N J, Meropol, W, Bolanowska-Higdon, J, Zdanowicz, M, Murphy, R, Perez
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(4)
Depletion of cellular glutathione (GSH) enhances the efficacy of many anticancer agents in preclinical systems. Limited published data showing depletion of GSH in vitro and in patients by ifosfamide and/or mesna provided the rationale for a Phase I t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5fd1e9e0c3958eb63238508812311e1b
https://pubmed.ncbi.nlm.nih.gov/10778956
https://pubmed.ncbi.nlm.nih.gov/10778956
Publikováno v:
Seminars in oncology. 24(4 Suppl 12)
The combination of paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) given by 3-hour infusion followed by carboplatin infused over 30 minutes has been evaluated in a series of phase I studies and is currently being explored in a phase I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cab6f3d99e3fbb3c42d7d9ebaa16402e
https://pubmed.ncbi.nlm.nih.gov/9331139
https://pubmed.ncbi.nlm.nih.gov/9331139
Autor:
L, Pendyala, S, Velagapudi, K, Toth, J, Zdanowicz, D, Glaves, H, Slocum, R, Perez, R, Huben, P J, Creaven, D, Raghavan
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 3(5)
Glutathione (GSH) levels were measured in 13 human tumor cell lines derived from carcinomas of the bladder, ovary, and colon and from melanoma and glioblastoma. High levels were found in four of five bladder cell lines. The average GSH concentration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::137df1eabe856001ed5fbd1be5a49b60
https://pubmed.ncbi.nlm.nih.gov/9815751
https://pubmed.ncbi.nlm.nih.gov/9815751
Publikováno v:
Seminars in oncology. 23(6 Suppl 16)
In preparation for the design of phase II studies in lung cancer, low-dose carboplatin, fixed at a target area under the concentration-time curve (AUC) of 4.0 or 4.5 mg x min/mL, has been combined with escalating doses of paclitaxel (Taxol; Bristol-M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cab13db5cc9ad4396228bc14a5373d2c
https://pubmed.ncbi.nlm.nih.gov/9007117
https://pubmed.ncbi.nlm.nih.gov/9007117
Autor:
N J, Meropol, M, Porter, L E, Blumenson, M J, Lindemann, R P, Perez, L, Vaickus, G M, Loewen, P J, Creaven, K A, Wilkes, M A, Giedlin, M A, Caligiuri
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 2(4)
We aimed to determine the toxicity and immunological effects of daily s.c. administered low-dose interleukin (IL) 2. Adult cancer patients received a single daily s.c. injection of IL-2 as outpatients for 90 consecutive days. Cohorts of four to nine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d6d7ae3130cbaacab40c6d676c6a1e96
https://pubmed.ncbi.nlm.nih.gov/9816217
https://pubmed.ncbi.nlm.nih.gov/9816217
Publikováno v:
Oncology research. 8(10-11)
Elevation of glutathione (GSH) is widely observed in cellular resistance to platinum agents. Our previous studies have shown that sublines of human ovarian carcinoma cell line A2780, which exhibited low levels of resistance to oxaliplatin, showed ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8bafcf08ae8b5fb865c843c6f9edda2b
https://pubmed.ncbi.nlm.nih.gov/9114434
https://pubmed.ncbi.nlm.nih.gov/9114434
Publikováno v:
Seminars in oncology. 22(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::98b3050d65d2e03f22ba69d464a72f39
https://pubmed.ncbi.nlm.nih.gov/7570061
https://pubmed.ncbi.nlm.nih.gov/7570061
Autor:
L, Pendyala, P J, Creaven
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 4(3)
A Phase I, pharmacokinetic and pharmacodynamic study of N-acetylcysteine (NAC), a potential chemopreventive agent, given daily p.o. for 6 months was carried out in 26 volunteers at higher than normal risk of malignancy. The goals of the study were to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f3b44d8673c19971137963d51558d999
https://pubmed.ncbi.nlm.nih.gov/7606199
https://pubmed.ncbi.nlm.nih.gov/7606199