Zobrazeno 1 - 10
of 12
pro vyhledávání: '"P. J. Crack"'
Autor:
Rajan Venkatraman, Katherine R. Balka, Wilson Wong, Jananipriya Sivamani, Zoe Magill, Kirsteen M. Tullett, Rachael M. Lane, Tahnee L. Saunders, Maximilien Tailler, Peter J. Crack, Linda M. Wakim, Mireille H. Lahoud, Kate E. Lawlor, Benjamin T. Kile, Meredith O’Keeffe, Dominic De Nardo
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110693- (2024)
Summary: The cGAS-STING pathway responds to cytosolic DNA to elicit host immunity to infection. The activation of stimulator of interferon genes (STING) can trigger a number of critical cellular responses including inflammation, noncanonical autophag
Externí odkaz:
https://doaj.org/article/4f6ffb7d172c46ffbb14376dc21aae1e
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Neuroinflammation driven by type-I interferons in the CNS is well established to exacerbate the progression of many CNS pathologies both acute and chronic. The role of adaptor protein Stimulator of Interferon Genes (STING) is increasingly appreciated
Externí odkaz:
https://doaj.org/article/b13578365db0403db981cb07fefe7e15
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-17 (2018)
Abstract Background Traumatic brain injury (TBI) represents a major cause of disability and death worldwide with sustained neuroinflammation and autophagy dysfunction contributing to the cellular damage. Stimulator of interferon genes (STING)-induced
Externí odkaz:
https://doaj.org/article/b63b248262424e34b757ef73edcc9944
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 8, Iss 6, Pp 889-899 (2018)
Interferons (IFNs) are cytokines with fundamental roles in resistance to infections, cancer and other diseases. Type-I IFNs, interferon α (IFN-α) and interferon β (IFN-β), act through a shared receptor complex (IFNAR) comprised of IFNAR1 and IFNA
Externí odkaz:
https://doaj.org/article/2e6976d12d0f432097878be8852ea8b9
Autor:
Sepideh Motamed, Mark P. Del Borgo, Kun Zhou, Ketav Kulkarni, Peter J. Crack, Tobias D. Merson, Marie-Isabel Aguilar, David I. Finkelstein, John S. Forsythe
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
Neural stem cells, which are confined in localised niches are unable to repair large brain lesions because of an inability to migrate long distances and engraft. To overcome these problems, previous research has demonstrated the use of biomaterial im
Externí odkaz:
https://doaj.org/article/ab37ac9151e2435e8ddbe6b4e2b0be95
Autor:
S, Hosie, T, Abo-Shaban, C Y Q, Lee, S M, Matta, A, Shindler, R, Gore, S S, Sharna, M, Herath, P J, Crack, A E, Franks, E L, Hill-Yardin
Publikováno v:
Advances in experimental medicine and biology. 1383
Autism spectrum disorder (ASD; autism) is a prevalent neurodevelopmental disorder associated with changes in gut-brain axis communication. Gastrointestinal (GI) symptoms are experienced by a large proportion of individuals diagnosed with autism. Seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cbde45f7e4397431e0ad08c5ddbad8d5
https://pubmed.ncbi.nlm.nih.gov/36587154
https://pubmed.ncbi.nlm.nih.gov/36587154
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7059 (2020)
Stimulator of interferon genes (STING)-mediated type-I interferon signaling is a well characterized instigator of the innate immune response following bacterial or viral infections in the periphery. Emerging evidence has recently linked STING to vari
Externí odkaz:
https://doaj.org/article/6bd85133e2e84db39b8b9a4808eb4f29
Autor:
S. Hosie, T. Abo-Shaban, C. Y. Q. Lee, S. M. Matta, A. Shindler, R. Gore, S. S. Sharna, M. Herath, P. J. Crack, A. E. Franks, E. L. Hill-Yardin
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783031058424
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bac80df5970f54732e3aea758b2414d3
https://doi.org/10.1007/978-3-031-05843-1_14
https://doi.org/10.1007/978-3-031-05843-1_14
Autor:
Catherine E Downes, Connie H Y Wong, Katya J Henley, Pedro L Guio-Aguilar, Moses Zhang, Robert Ates, Ashley Mansell, Benjamin T Kile, Peter J Crack
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57948 (2013)
Neuroinflammation is critical in the neural cell death seen in stroke. It has been shown that CNS and peripheral responses drive this neuroinflammatory response in the brain. The Toll-like receptors (TLRs) are important regulators of inflammation in
Externí odkaz:
https://doaj.org/article/aba7a1673b1c4d669cd0e9194af99a57
Autor:
Benjamin J Wheaton, Natassya M Noor, Sophie C Whish, Jessie S Truettner, W Dalton Dietrich, Moses Zhang, Peter J Crack, Katarzyna M Dziegielewska, Norman R Saunders
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71181 (2013)
Complete spinal transection in the mature nervous system is typically followed by minimal axonal repair, extensive motor paralysis and loss of sensory functions caudal to the injury. In contrast, the immature nervous system has greater capacity for r
Externí odkaz:
https://doaj.org/article/864a4436b043436a9e669fe143b358b2