Zobrazeno 1 - 10
of 21
pro vyhledávání: '"P. J. Catanzaro"'
Autor:
Yinzhu Jin, Rory McDaniel, N. Joseph Tatro, Michael J. Catanzaro, Abraham D. Smith, Paul Bendich, Matthew B. Dwyer, P. Thomas Fletcher
Publikováno v:
Frontiers in Computer Science, Vol 6 (2024)
Many deep generative models, such as variational autoencoders (VAEs) and generative adversarial networks (GANs), learn an immersion mapping from a standard normal distribution in a low-dimensional latent space into a higher-dimensional data space. As
Externí odkaz:
https://doaj.org/article/27a48a21b24043779d3800b7b6875e1f
Autor:
A. Brenda Kapingidza, Daniel J. Marston, Caitlin Harris, Daniel Wrapp, Kaitlyn Winters, Dieter Mielke, Lu Xiaozhi, Qi Yin, Andrew Foulger, Rob Parks, Maggie Barr, Amanda Newman, Alexandra Schäfer, Amanda Eaton, Justine Mae Flores, Austin Harner, Nicholas J. Catanzaro, Michael L. Mallory, Melissa D. Mattocks, Christopher Beverly, Brianna Rhodes, Katayoun Mansouri, Elizabeth Van Itallie, Pranay Vure, Brooke Dunn, Taylor Keyes, Sherry Stanfield-Oakley, Christopher W. Woods, Elizabeth A. Petzold, Emmanuel B. Walter, Kevin Wiehe, Robert J. Edwards, David C. Montefiori, Guido Ferrari, Ralph Baric, Derek W. Cain, Kevin O. Saunders, Barton F. Haynes, Mihai L. Azoitei
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Immune responses to SARS-CoV-2 primarily target the receptor binding domain of the spike protein, which continually mutates to escape acquired immunity. Other regions in the spike S2 subunit, such as the stem helix and the segment encompassi
Externí odkaz:
https://doaj.org/article/f7c3c671d32d475aacf1c3a48887812f
Autor:
Drake T. Philip, Nigel M. Goins, Nicholas J. Catanzaro, Ichiro Misumi, Jason K. Whitmire, Hannah M. Atkins, Helen M. Lazear
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTType III interferons (IFN-λ) are antiviral and immunomodulatory cytokines that have been best characterized in respiratory and gastrointestinal infections, but the effects of IFN-λ against skin infections have not been extensively investiga
Externí odkaz:
https://doaj.org/article/8b8c514b3e5746b5ada001da89837ded
Autor:
Meghan V. Diefenbacher, Thomas J. Baric, David R. Martinez, Ralph S. Baric, Nicholas J. Catanzaro, Timothy P. Sheahan
Publikováno v:
Virus Research, Vol 339, Iss , Pp 199286- (2024)
The genetic diversity of the coronavirus (CoV) family poses a significant challenge for drug discovery and development. Traditional antiviral drugs often target specific viral proteins from specific viruses which limits their use, especially against
Externí odkaz:
https://doaj.org/article/f4cb635a13784784a2d1ae931b9ec45c
Autor:
John N Snouwaert, Leigh A Jania, Trang Nguyen, David R Martinez, Alexandra Schäfer, Nicholas J Catanzaro, Kendra L Gully, Ralph S Baric, Mark Heise, Martin T Ferris, Elizabeth Anderson, Katia Pressey, Jacob A Dillard, Sharon Taft-Benz, Victoria K Baxter, Jenny P-Y Ting, Beverly H Koller
Publikováno v:
PLoS Pathogens, Vol 19, Iss 2, p e1011168 (2023)
Angiotensin-converting enzyme 2 (ACE2), part of the renin-angiotensin system (RAS), serves as an entry point for SARS-CoV-2, leading to viral proliferation in permissive cell types. Using mouse lines in which the Ace2 locus has been humanized by synt
Externí odkaz:
https://doaj.org/article/75be0b479d294111a5b725cdfbedb42c
Autor:
Andrew Salch, Adam Regalski, Hassan Abdallah, Raviteja Suryadevara, Michael J Catanzaro, Vaibhav A Diwadkar
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0255859 (2021)
fMRI is the preeminent method for collecting signals from the human brain in vivo, for using these signals in the service of functional discovery, and relating these discoveries to anatomical structure. Numerous computational and mathematical techniq
Externí odkaz:
https://doaj.org/article/f05de3bfb5d74a6d8c68193daffd092f
Autor:
P. J. Catanzaro
Publikováno v:
Journal of Clinical Oncology. 26:12024-12024
12024 Some early stage breast cancer patients bear sub-clinical nodal and/or distant metastases. After primary extirpation, the proportion of failure is lower than would be expected in non-dissected axilla patients and in bone marrow biopsy positive
Publikováno v:
Infection and Immunity. 13:861-875
Intraperitoneal (i.p.) infection of BALB/c mice with 1,000 50% mouse lethal doses of the Karp strain of Rickettsia tsutsugamushi was inevitably lethal, and associated pathological alterations were confined to the peritoneal cavity. These included: (i
Publikováno v:
Infection and Immunity. 18:118-123
Lymphocytes obtained from spleens or peritoneal exudates of immune donor mice were evaluated for their ability to passively confer protection on recipients subsequently challenged with virulent scrub typhus rickettsiae. Peritoneal exudate lymphocytes
Publikováno v:
Infection and Immunity. 14:39-46
The relative contributions of cellular and humoral immunity in scrub typhus infections were studied in inbred mice employing paired strains of Rickettsia tsutsugamushi differing in virulence. An infectious dose (100 MID50) of the less virulent Gillia