Zobrazeno 1 - 10
of 75
pro vyhledávání: '"P. I. Webb"'
Publikováno v:
Financial Innovation, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract In the blockchain world, proof-of-work is the dominant protocol mechanism that determines the consensus of the ledger. The hashrate, a measure of the computational power directed toward securing a blockchain through proof-of-work consensus,
Externí odkaz:
https://doaj.org/article/8565968b8acf4cf992f37816242ee85e
Autor:
Hoai-An Nguyen, Anton Y. Peleg, Jiangning Song, Bhavna Antony, Geoffrey I. Webb, Jessica A. Wisniewski, Luke V. Blakeway, Gnei Z. Badoordeen, Ravali Theegala, Helen Zisis, David L. Dowe, Nenad Macesic
Publikováno v:
mSystems, Vol 9, Iss 9 (2024)
ABSTRACT Matrix-assisted laser desorption/ionization–time of flight mass spectrometry (MALDI-TOF MS) is widely used in clinical microbiology laboratories for bacterial identification but its use for detection of antimicrobial resistance (AMR) remai
Externí odkaz:
https://doaj.org/article/7cdd394611be42aa8483358a964f7057
Autor:
Shannon Nicolson, Jantina A. Manning, Yoon Lim, Xin Jiang, Erica Kolze, Sonia Dayan, Ruchi Umargamwala, Tianqi Xu, Jarrod J. Sandow, Andrew I. Webb, Sharad Kumar, Donna Denton
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-24 (2024)
Abstract Autophagy, the process of elimination of cellular components by lysosomal degradation, is essential for animal development and homeostasis. Using the autophagy-dependent Drosophila larval midgut degradation model we identified an autophagy r
Externí odkaz:
https://doaj.org/article/48b9fe21c5fc45f2b5b559b3895df865
Autor:
Daniela Fietz, Raouda Sgaier, Liza O’Donnell, Peter G. Stanton, Laura F. Dagley, Andrew I. Webb, Hans-Christian Schuppe, Thorsten Diemer, Adrian Pilatz
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionAzoospermia, characterized by an absence of sperm in the ejaculate, represents the most severe form of male infertility. While surgical sperm retrieval in obstructive azoospermia (OA) is successful in the majority of cases, patients with
Externí odkaz:
https://doaj.org/article/05dd56e6fba143f3ae70adeae3afa88a
Publikováno v:
Financial Innovation, Vol 9, Iss 1, Pp 1-23 (2023)
Abstract How does stablecoin design affect market behavior during turbulent periods? Stablecoins attempt to maintain a “stable” peg to the US dollar, but do so with widely varying structural designs. The spectacular collapse of the TerraUSD (UST)
Externí odkaz:
https://doaj.org/article/598c285a21c64052abee9916c3423b83
Autor:
Kirti Pandey, Stacie S. Wang, Nicole A. Mifsud, Pouya Faridi, Alexander J. Davenport, Andrew I. Webb, Jarrod J. Sandow, Rochelle Ayala, Michelle Monje, Ryan S. Cross, Sri H. Ramarathinam, Misty R. Jenkins, Anthony W. Purcell
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionDiffuse intrinsic pontine glioma (DIPG), recently reclassified as a subtype of diffuse midline glioma, is a highly aggressive brainstem tumor affecting children and young adults, with no cure and a median survival of only 9 months. Conven
Externí odkaz:
https://doaj.org/article/cca9faeeedb64a64829693d53680c424
Publikováno v:
Borsa Istanbul Review, Vol 22, Iss 4, Pp 627-640 (2022)
This study reexamines the influence of different investor types' net options demand on the KOSPI200 options-implied volatility dynamics. We extend Bollen and Whaley (2004) by accounting for options traders' hedging demand for futures contracts, intra
Externí odkaz:
https://doaj.org/article/753dac9e1fa44fd3947a8c20c42ecdf1
Autor:
Yanan Wang, Yu Guang Wang, Changyuan Hu, Ming Li, Yanan Fan, Nina Otter, Ikuan Sam, Hongquan Gou, Yiqun Hu, Terry Kwok, John Zalcberg, Alex Boussioutas, Roger J. Daly, Guido Montúfar, Pietro Liò, Dakang Xu, Geoffrey I. Webb, Jiangning Song
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-12 (2022)
Abstract Gastric cancer is one of the deadliest cancers worldwide. An accurate prognosis is essential for effective clinical assessment and treatment. Spatial patterns in the tumor microenvironment (TME) are conceptually indicative of the staging and
Externí odkaz:
https://doaj.org/article/96cc8ae4ef144bf9ba1ae0752827cb29
Autor:
Swarna L. Vijayaraj, Rebecca Feltham, Maryam Rashidi, Daniel Frank, Zhengyang Liu, Daniel S. Simpson, Gregor Ebert, Angelina Vince, Marco J. Herold, Andrew Kueh, Jaclyn S. Pearson, Laura F. Dagley, James M. Murphy, Andrew I. Webb, Kate E. Lawlor, James E. Vince
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Hyperactivation of inflammasome-induced IL-1β can cause immunopathology and is a feature of autoinflammatory diseases. Here, the authors show how ubiquitination of IL-1β limits its activity by targeting it for proteasomal degradation and preventing
Externí odkaz:
https://doaj.org/article/15cc2871bf48403c8f2afd5582cbe869
Autor:
Sarah E. Garnish, Yanxiang Meng, Akiko Koide, Jarrod J. Sandow, Eric Denbaum, Annette V. Jacobsen, Wayland Yeung, Andre L. Samson, Christopher R. Horne, Cheree Fitzgibbon, Samuel N. Young, Phoebe P. C. Smith, Andrew I. Webb, Emma J. Petrie, Joanne M. Hildebrand, Natarajan Kannan, Peter E. Czabotar, Shohei Koide, James M. Murphy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Mixed Lineage Kinase Domain-Like (MLKL) pseudokinase is phosphorylated by RIPK3 kinase prior to cell death by necroptosis. Here, the authors use monobodies that bind to the MLKL pseudokinase domain as tools, which allowed them to determine the crysta
Externí odkaz:
https://doaj.org/article/09c7c00c35d347a0a64667b29956b651