Výsledky vyhledávání - "P. I. Lukienko"

[The effect of methotrexate on phenobarbital induction of monooxygenases and UDP-glucuronyltransferases in rat liver]

Autor: P I, Lukienko, L F, Legon'kova, M I, Bushma, A Iu, Shoka, I V, Zverinskiĭ, L B, Zavodnik

Publikováno v: Voprosy meditsinskoi khimii. 39(3)

Methotrexate (N10-methyl-4-amino-4-deoxyfolic acid), administered to rats subcutaneously at a dose of 0.25 mg/kg within 14 days, was found to decrease content of microsomal protein in liver tissue and content of cytochromes P-450 and b5 as well as th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ea906c16d8e035c67ecb30feef28a7c
https://pubmed.ncbi.nlm.nih.gov/8333187

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[Diethylnicotinamid (cordiamine) stabilization of the liver hydroxylating function in rabbits with CCl4 poisoning]

Autor: L B, Zavodnik, M I, Bushma, P I, Lukienko, G Z, Abakumov, I V, Zverinskiĭ, V M, Tsyrkunov

Publikováno v: Farmakologiia i toksikologiia. 54(4)

Three and ten days after the administration of CCl4 (subcutaneously, once, 4 ml/kg of 50% oil solution) there were found a decrease of the rate of antipyrine elimination (intravenously, 50 mg/kg) from the blood plasma, an increase of the total biliru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d52ae1d972c255982672782176000588
https://pubmed.ncbi.nlm.nih.gov/1786835

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[A comparative study of the effects of nicotinamide and diethylnicotinamid on hepatic monooxygenase, glucuronyl and glutathione conjugating systems]

Autor: L F, Legon'kova, M I, Bushma, P I, Lukienko

Publikováno v: Biulleten' eksperimental'noi biologii i meditsiny. 110(12)

The nicotinamide administration to rats (50 mg/kg, subcutaneously, over 5 days) increased the concentration of liver cytochrome b5, the activities of cytosol and microsomal glutathione S-transferase, UDP-glucuronosyltransferase and urinary excretion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::325ff983eacb4b71442268c747c06354
https://pubmed.ncbi.nlm.nih.gov/2150602

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[Changes in UDP-glucuronosyl-, glutathione-S-transferase and lipid peroxidation in rat liver microsomes during gamma-irradiation and protective effect of alpha-tocopherol]

Autor: L F, Legon'kova, G Z, Abakumov, M I, Bushma, P I, Lukienko

Publikováno v: Voprosy meditsinskoi khimii. 36(3)

Stimulation of lipid peroxidation, accompanied by a decrease in activity of UDP-glucuronyl- and glutathione-S-transferases, was observed in rat liver microsomes within one day after gamma-irradiation. Maximal alteration of the patterns studied was de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::642de9c60cbed1ea2b6d603f722dfc57
https://pubmed.ncbi.nlm.nih.gov/2116695

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[The effect of diethylnicotinamide (cordiamine) on the activity of the hydroxylating and glucuronyl-conjugating systems in humans]

Autor: L B, Zavodnik, V M, Tsyrkunov, M I, Bushma, P I, Lukienko, L F, Legon'kova

Publikováno v: Farmakologiia i toksikologiia. 53(2)

Administration of diethylnicotinamide (250 mg orally three times for 8 days) to healthy subjects increased antipyrine (AP) elimination from the saliva by 23% and decreased its half-life by 26%. The excretion in the urine of the products of AP hydroxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c772046bf1f9e6866016cb316831c380
https://pubmed.ncbi.nlm.nih.gov/2115011

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